Search Results - "KATO, Yukio"

Ergothioneine in the brain by Ishimoto, Takahiro, Kato, Yukio

“…Ergothioneine (ERGO) is a naturally occurring food‐derived antioxidant. Despite its extremely hydrophilic properties, ERGO is easily absorbed from the…”
Get full text

Development of the anterior pituitary: diverse lineages of the stem/progenitor cells by Kato, Yukio, Kato, Takako

“…The pituitary gland is endocrine tissue composed of two distinct parts with different origins: the adenohypophysis (adenohypophyseal placode origin) and the…”
Get full text

Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells by Nakamichi, Noritaka, Kato, Yukio

“…Dysfunction in neurotransmission mediated by neurotransmitters causes various neurological disorders. Therefore, receptors and reuptake transporters of…”
Get full text

New insights into the role and origin of pituitary S100β-positive cells by Kato, Yukio, Yoshida, Saishu, Kato, Takako

“…In the anterior pituitary, S100β protein (S100β) has been assumed to be a marker of folliculo-stellate cells, which are one of the non-hormone-producing cells…”
Get full text

Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland by Kato, Yukio, Yoshida, Saishu, Kato, Takako

“…The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin) and the…”
Get full text

Functional Expression of Carnitine/Organic Cation Transporter 1 in Murine Choroid Plexus by Ishimoto, Takahiro, Nakamichi, Noritaka, Taguchi, Takayuki, Nishiyama, Misa, Kato, Yukio

“…Membrane transporters expressed in the choroid plexus (CP) are involved in the transport of substances between the blood and cerebrospinal fluid (CSF)…”
Get full text

Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells by Ishimoto, Takahiro, Masuo, Yusuke, Kato, Yukio, Nakamichi, Noritaka

“…The promotion of neurogenesis is considered to be an effective therapeutic strategy for neuropsychiatric disorders because impairment of neurogenesis is…”
Get full text

Effects of Probenecid on Hepatic and Renal Disposition of Hexadecanedioate, an Endogenous Substrate of Organic Anion Transporting Polypeptide 1B in Rats by Futatsugi, Azusa, Masuo, Yusuke, Kato, Yukio

“…The aim of the present study was to investigate changes in plasma concentrations and tissue distribution of endogenous substrates of organic anion transporting…”
Get more information

Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis by Kanai, Ryo, Nakashima, Ayumu, Doi, Shigehiro, Kimura, Tomoe, Yoshida, Ken, Maeda, Satoshi, Ishiuchi, Naoki, Yamada, Yumi, Ike, Takeshi, Doi, Toshiki, Kato, Yukio, Masaki, Takao

“…Mesenchymal stem cells (MSCs) administered for therapeutic purposes can be activated by interferon-γ (IFN-γ) secreted from natural killer cells in injured…”
Get full text

DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli by Kato, Yukio, Kawamoto, Takeshi, Fujimoto, Katsumi, Noshiro, Mitsuhide

“…Daily physiological and behavioral rhythms are regulated by endogenous circadian molecular clocks. Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to…”
Get full text

High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons by Takahashi, Yasufumi, Zhou, Yuanshu, Miyamoto, Takafumi, Higashi, Hiroki, Nakamichi, Noritaka, Takeda, Yuka, Kato, Yukio, Korchev, Yuri, Fukuma, Takeshi

“…Dynamic reassembly of the cytoskeleton and structural changes represented by dendritic spines, cargo transport, and synapse formation are closely related to…”
Get full text

Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells by Tao, Fumiya, Hanada, Sanshiro, Matsushima, Kazuya, Arakawa, Hiroshi, Ishida, Naoki, Kato, Yukio, Okimura, Saya, Watanabe, Tomohisa, Kojima, Nobuhiko

“…Hepatocyte-like cells (HLCs) generated from human induced pluripotent stem cells are potent cells to study individual-specific hepatotoxicity for drug…”
Get full text

A Liposomal Gemcitabine, FF-10832, Improves Plasma Stability, Tumor Targeting, and Antitumor Efficacy of Gemcitabine in Pancreatic Cancer Xenograft Models by Matsumoto, Takeshi, Komori, Takashi, Yoshino, Yuta, Ioroi, Tadaaki, Kitahashi, Tsukasa, Kitahara, Hiromu, Ono, Kohei, Higuchi, Tamami, Sakabe, Masayo, Kori, Hiroshi, Kano, Masahiro, Hori, Ritsuko, Kato, Yukio, Hagiwara, Shinji

“…Purpose The clinical application of gemcitabine (GEM) is limited by its pharmacokinetic properties. The aim of this study was to characterize the stability in…”
Get full text

Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system by Arakawa, Hiroshi, Sugiura, Shinji, Kawanishi, Takumi, Shin, Kazumi, Toyoda, Hiroko, Satoh, Taku, Sakai, Yasuyuki, Kanamori, Toshiyuki, Kato, Yukio

“…The microphysiological system (MPS) is a promising tool for predicting drug disposition in humans, although limited information is available on the…”
Get more information

Short-lasting inhibition of hepatic uptake transporter OATP1B1 by tyrosine kinase inhibitor pazopanib by Taguchi, Takayuki, Masuo, Yusuke, Sakai, Yoshiyuki, Kato, Yukio

“…Risk assessment of organic anion transporting polypeptide 1B1 (OATP1B1)-mediated drug-drug interactions (DDIs) is an integral part of drug development, but the…”
Get full text

CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression of coherent circadian rhythm but not in generation of circadian oscillation in the neonatal mouse SCN by Ono, Daisuke, Honma, Ken-ichi, Schmal, Christoph, Takumi, Toru, Kawamoto, Takeshi, Fujimoto, Katsumi, Kato, Yukio, Honma, Sato

“…Clock genes Cry1 and Cry2 , inhibitory components of core molecular feedback loop, are regarded as critical molecules for the circadian rhythm generation in…”
Get full text

Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats by Ishiuchi, Naoki, Nakashima, Ayumu, Doi, Shigehiro, Yoshida, Ken, Maeda, Satoshi, Kanai, Ryo, Yamada, Yumi, Ike, Takeshi, Doi, Toshiki, Kato, Yukio, Masaki, Takao

“…Mesenchymal stem cells (MSCs) have been reported to promote the regeneration of injured tissue via their paracrine abilities, which are enhanced by hypoxic…”
Get full text

Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells by Ishimoto, Takahiro, Nakamichi, Noritaka, Nishijima, Hikari, Masuo, Yusuke, Kato, Yukio

“…Brain immune cells, i.e., microglia, play an important role in the maintenance of brain homeostasis, whereas chronic overactivation of microglia is involved in…”
Get full text

A novel protein, CHRONO, functions as a core component of the mammalian circadian clock by Goriki, Akihiro, Hatanaka, Fumiyuki, Myung, Jihwan, Kim, Jae Kyoung, Yoritaka, Takashi, Tanoue, Shintaro, Abe, Takaya, Kiyonari, Hiroshi, Fujimoto, Katsumi, Kato, Yukio, Todo, Takashi, Matsubara, Akio, Forger, Daniel, Takumi, Toru

“…Circadian rhythms are controlled by a system of negative and positive genetic feedback loops composed of clock genes. Although many genes have been implicated…”
Get full text

Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin by Futatsugi, Azusa, Toshimoto, Kota, Yoshikado, Takashi, Sugiyama, Yuichi, Kato, Yukio

“…Polymorphism c.421C>A in the gene is thought to reduce the activity of breast cancer resistance protein (BCRP), a xenobiotic transporter, although it is not…”
Get full text