The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland : A case report and review

The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland : A case report and review

The growing teratoma syndrome is a recognized complication of metastatic nonseminomatous germ cell tumors of the testis and is managed surgically. It may also occur in intracranial nongerminomatous germ cell tumors. The authors performed an English language computer search using the EMBASE data base...

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Bibliographic Details
Published in:Cancer Vol. 80; no. 5; pp. 942 - 947
Main Authors: O'CALLAGHAN, A. M, KATAPODIS, O, ELLISON, D. W, THEAKER, J. M, MEAD, G. M
Format: Journal Article
Language:English
Published: New York, NY Wiley-Liss 01-09-1997
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Bleomycin - administration & dosage
Cisplatin - administration & dosage
Diagnosis, Differential
Endocrinopathies
Endodermal Sinus Tumor - drug therapy
Endodermal Sinus Tumor - pathology
Etoposide - administration & dosage
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Leucovorin - administration & dosage
Male
Malignant tumors
Medical sciences
Methotrexate - administration & dosage
Neoplasms, Germ Cell and Embryonal - drug therapy
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Second Primary - drug therapy
Neoplasms, Second Primary - pathology
Neoplasms, Second Primary - surgery
Pineal Gland - pathology
Syndrome
Teratoma - drug therapy
Teratoma - pathology
Teratoma - surgery
Vincristine - administration & dosage
Endocrinopathy
Human
Antineoplastic agent
Growth
Pineal diseases
Pineal body
Malignant tumor
Malignant teratoma
Case study
Germ cell tumor
Chemotherapy
Treatment
Adolescent
Complication
Bibliographic review
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Description
Summary:The growing teratoma syndrome is a recognized complication of metastatic nonseminomatous germ cell tumors of the testis and is managed surgically. It may also occur in intracranial nongerminomatous germ cell tumors. The authors performed an English language computer search using the EMBASE data base (from January 1980 to December 1996) for pineal tumors, read all abstracts, and then selected all articles pertaining to germ cell tumors at this site. The case history of a 19-year-old male who presented with a pineal nongerminomatous germ cell tumor, which was treated with chemotherapy, is reported. Despite normalization of raised tumor marker levels, the pineal mass enlarged during chemotherapy. This was excised and proved to be a mature teratoma. A review of the literature regarding this complication of intracranial germ cell tumors is also presented. The authors believe this to be the first reported case of growing teratoma syndrome in the pineal gland of an adult patient, two previously reported cases occurred in children. The authors conclude that the pineal gland is an unusual but important site in which to recognize the growing teratoma syndrome.
ISSN:0008-543X
1097-0142
DOI:10.1002/(SICI)1097-0142(19970901)80:5<942::AID-CNCR16>3.0.CO;2-W