BASIC AND CLINICAL STUDIES ON CEFETAMET PIVOXIL IN UROLOGY

We basically and clinically evaluated cefetamet pivoxil, a new oral cephalosporin, in the urological field. 1) The in vitro antimicrobial activity of cefetamet (CEMT) was compared with those of cefaclor (CCL), cefteram (CFTM) and cefixime (CFIX) against 2 Gram-positive cocci and 8 Gram-negative baci...

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Published in:	CHEMOTHERAPY Vol. 38; no. Supplement1; pp. 240 - 249
Main Authors:	KO, ZHAO-REN, KUWAYAMA, MASAYUKI, YAMASHITA, MASUO, ARAKAWA, SOICHI, MATSUMOTO, OSAMU, KAMIDOMO, SADAO, KATAOKA, NOBUTOSH, UMEZU, KEIICHI, TOMIOKA, OSAMU, FUJII, AKIRA, HIROOKA, KUHEI, YASUMURO, CHOZO, HAMAMI, GAKU, OHSIMA, HIDEO
Format:	Journal Article
Language:	English Japanese
Published:	Japanese Society of Chemotherapy 1990
Subjects:	Cefetamet pivoxil
Online Access:	Get full text
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Summary:	We basically and clinically evaluated cefetamet pivoxil, a new oral cephalosporin, in the urological field. 1) The in vitro antimicrobial activity of cefetamet (CEMT) was compared with those of cefaclor (CCL), cefteram (CFTM) and cefixime (CFIX) against 2 Gram-positive cocci and 8 Gram-negative bacilli of a total 357 clinical isolates.Its activity against Proteus mirabilis and Klebsiella pneumoniae was similar to that of CFTM but slightly inferior to that of CFIX. It showed no activity against Enterococcus faecalis and Pseudomonas aeruginosa. 2) The diffusion of CEMT into the prostatic fluid (PF) was studied in six healthy male volunteers by means of expressed prostatic secretion 2, 3 and 4 hours after oral administration of 0.5g in a single dose. The drug concentrations in PF were<0.1-3.9μg/ml, <0.1-0.67μg/ml, <0.1-0.88μg/ml, respectively, and the PF serum ratio ranged from 0.06 to 0.07. 3) The clinical efficacy in 50 patients with various types of genito-urinary tract infection was evaluated by oral administration of 0.25g or 0.5g two times daily for 3-14 days. The 50 cases comprised 21 cases of with acute uncomplicated cystitis (AUC), 1 of acute epididymitis and 28 of complicated urinary tract infection (UTI). According to the criteria of the Japanese UTI Committee, the overall clinical efficacy rate was 100%(10/10) in AUC and 67%(12/18) in complicated UTI. The bacteriological eradication rate was 100%(10/10) in AUC and 81%(17/21) in complicated UTI. The side effect was stomach discomfort in one patient, and slight elevation of GOT and GPT in one patient.
ISSN:	0009-3165 1884-5894
DOI:	10.11250/chemotherapy1953.38.Supplement1_240