Search Results - "KASTNER, Daniel L"

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS by Park, Yong Hwan, Wood, Geryl, Kastner, Daniel L, Chae, Jae Jin

“…Gain-of-function mutations in the gene encoding pyrin result in spontaneous autoinflammatory disease. Chae and colleagues detail a mechanism involving RhoA…”
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The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation by Manthiram, Kalpana, Zhou, Qing, Aksentijevich, Ivona, Kastner, Daniel L

“…Kastner and colleagues review monogenic autoinflammatory diseases and their molecular mechanisms and explore the overlap among autoinflammation, autoimmunity…”
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The Pyrin Inflammasome in Health and Disease by Schnappauf, Oskar, Chae, Jae Jin, Kastner, Daniel L, Aksentijevich, Ivona

“…The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a…”
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Autoinflammatory Disease Reloaded: A Clinical Perspective by Kastner, Daniel L., Aksentijevich, Ivona, Goldbach-Mansky, Raphaela

“…Our understanding of the etiology of autoinflammatory disease is growing rapidly. Recent advances offer new opportunities for therapeutic intervention and…”
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Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease () by Masters, Seth L, Simon, Anna, Aksentijevich, Ivona, Kastner, Daniel L

“…The autoinflammatory diseases are characterized by seemingly unprovoked episodes of inflammation, without high-titer autoantibodies or antigen-specific T…”
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Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) by Bulua, Ariel C, Simon, Anna, Maddipati, Ravikanth, Pelletier, Martin, Park, Heiyoung, Kim, Kye-Young, Sack, Michael N, Kastner, Daniel L, Siegel, Richard M

“…Reactive oxygen species (ROS) have an established role in inflammation and host defense, as they kill intracellular bacteria and have been shown to activate…”
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases by Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

“…A selective, small-molecule inhibitor of NLRP3 suppresses activation of the inflammasome in vitro and in vivo and attenuates inflammatory disease. The NOD-like…”
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The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome by Chung, Lawton K., Park, Yong Hwan, Zheng, Yueting, Brodsky, Igor E., Hearing, Patrick, Kastner, Daniel L., Chae, Jae Jin, Bliska, James B.

“…Pathogenic Yersinia, including Y. pestis, the agent of plague in humans, and Y. pseudotuberculosis, the related enteric pathogen, deliver virulence effectors…”
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Old Dogs, New Tricks: Monogenic Autoinflammatory Disease Unleashed by Stoffels, Monique, Kastner, Daniel L

“…Autoinflammatory diseases are inborn disorders of the innate immune system characterized by episodes of systemic inflammation that are mediated largely by…”
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Treatment Strategies for Deficiency of Adenosine Deaminase 2 by Ombrello, Amanda K, Qin, Jing, Hoffmann, Patrycja M, Kumar, Parag, Stone, Deborah, Jones, Anne, Romeo, Tina, Barham, Beverly, Pinto-Patarroyo, Gineth, Toro, Camilo, Soldatos, Ariane, Zhou, Qing, Deuitch, Natalie, Aksentijevich, Ivona, Sheldon, Sherry L, Kelly, Susan, Man, Ada, Barron, Karyl, Hershfield, Michael, Flegel, Willy A, Kastner, Daniel L

“…The manifestations of a deficiency of adenosine deaminase 2, a genetic disease, include early-onset lacunar stroke. In a series of 15 patients with this…”
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Lighting the fires within: the cell biology of autoinflammatory diseases by Park, Heiyoung, Bourla, Ariel Bulua, Kastner, Daniel L., Colbert, Robert A., Siegel, Richard M.

“…Key Points Autoinflammatory diseases are marked by uncontrolled inflammation in the absence of autoantibodies or autoreactive T cell responses. The genetic…”
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Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease by Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona

“…Systemic autoinflammatory diseases are caused by mutations in genes that function in innate immunity. Here, we report an autoinflammatory disease caused by…”
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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells by Masters, Seth L., Gerlic, Motti, Metcalf, Donald, Preston, Simon, Pellegrini, Marc, O’Donnell, Joanne A., McArthur, Kate, Baldwin, Tracey M., Chevrier, Stephane, Nowell, Cameron J., Cengia, Louise H., Henley, Katya J., Collinge, Janelle E., Kastner, Daniel L., Feigenbaum, Lionel, Hilton, Douglas J., Alexander, Warren S., Kile, Benjamin T., Croker, Ben A.

“…Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for…”
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages by Sokolowska, Milena, Chen, Li-Yuan, Liu, Yueqin, Martinez-Anton, Asuncion, Qi, Hai-Yan, Logun, Carolea, Alsaaty, Sara, Park, Yong Hwan, Kastner, Daniel L, Chae, Jae Jin, Shelhamer, James H

“…PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and…”
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Gain-of-Function Pyrin Mutations Induce NLRP3 Protein -Independent Interleukin-1β Activation and Severe Autoinflammation in Mice by Chae, Jae Jin, Cho, Young-Hun, Lee, Geun-Shik, Cheng, Jun, Liu, P. Paul, Feigenbaum, Lionel, Katz, Stephen I., Kastner, Daniel L.

“…Missense mutations in the C-terminal B30.2 domain of pyrin cause familial Mediterranean fever (FMF), the most common Mendelian autoinflammatory disease…”
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Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B51 and ERAP1 by Kirino, Yohei, Bertsias, George, Ishigatsubo, Yoshiaki, Mizuki, Nobuhisa, Tugal-Tutkun, Ilknur, Seyahi, Emire, Ozyazgan, Yilmaz, Sacli, F Sevgi, Erer, Burak, Inoko, Hidetoshi, Emrence, Zeliha, Cakar, Atilla, Abaci, Neslihan, Ustek, Duran, Satorius, Colleen, Ueda, Atsuhisa, Takeno, Mitsuhiro, Kim, Yoonhee, Wood, Geryl M, Ombrello, Michael J, Meguro, Akira, Gül, Ahmet, Remmers, Elaine F, Kastner, Daniel L

“…Daniel Kastner and colleagues report genome-wide association analyses for Behçet's disease, a condition characterized by episodic inflammation of the skin and…”
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Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis by Park, Yong Hwan, Remmers, Elaine F., Lee, Wonyong, Ombrello, Amanda K., Chung, Lawton K., Shilei, Zhao, Stone, Deborah L., Ivanov, Maya I., Loeven, Nicole A., Barron, Karyl S., Hoffmann, Patrycja, Nehrebecky, Michele, Akkaya-Ulum, Yeliz Z., Sag, Erdal, Balci-Peynircioglu, Banu, Aksentijevich, Ivona, Gül, Ahmet, Rotimi, Charles N., Chen, Hua, Bliska, James B., Ozen, Seza, Kastner, Daniel L., Shriner, Daniel, Chae, Jae Jin

“…Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV , which…”
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Genetics of monogenic autoinflammatory diseases: past successes, future challenges by Aksentijevich, Ivona, Kastner, Daniel L

“…Advances in genetic research and technology have provided great insights into the pathogenesis of inherited diseases of the innate immune system. In this…”
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A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency by Zhou, Qing, Lee, Geun-Shik, Brady, Jillian, Datta, Shrimati, Katan, Matilda, Sheikh, Afzal, Martins, Marta S, Bunney, Tom D, Santich, Brian H, Moir, Susan, Kuhns, Douglas B, Long Priel, Debra A, Ombrello, Amanda, Stone, Deborah, Ombrello, Michael J, Khan, Javed, Milner, Joshua D, Kastner, Daniel L, Aksentijevich, Ivona

“…Whole-exome sequencing was performed in a family affected by dominantly inherited inflammatory disease characterized by recurrent blistering skin lesions,…”
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Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy by Chae, Jae J., Aksentijevich, Ivona, Kastner, Daniel L.

“…Summary Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder characterized by seemingly unprovoked recurrent episodes of fever and…”
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