Search Results - "KASPRZAK, K. S"

Possible role of oxidative damage in metal-induced carcinogenesis by Kasprzak, K S

“…This review presents and evaluates evidence relevant to the mechanisms of metal carcinogenicity with special emphasis on the emerging hypothesis of the…”
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The role of oxidative damage in metal carcinogenicity by Kasprzak, Kazimierz S

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Effects of Ni(II) and Cu(II) on DNA interaction with the N-terminal sequence of human protamine P2: enhancement of binding and mediation of oxidative DNA strand scission and base damage by Liang, Rongti, Senturker, Sema, Shi, Xianglin, Bal, Wojciech, Dizdarogluand, Miral, Kasprzak, Kazimierz S.

“…Epidemiological evidence suggests that certain paternal exposures to metals may increase the risk of cancer in the progeny. This effect may be associated with…”
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Oxidative DNA and protein damage in metal-induced toxicity and carcinogenesis by Kasprzak, Kazimierz S

“…This review discusses the relevance of oxidative damage to metal-induced toxicity and carcinogenesis. Presented are important facts and mechanistic concepts on…”
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Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus by Sipowicz, MA, Chomarat, P, Diwan, BA, Anver, MA, Awasthi, YC, Ward, JM, Rice, JM, Kasprzak, KS, Wild, CP, Anderson, LM

“…A recently discovered bacterium, Helicobacter hepaticus, infects the intrahepatic bile canaliculi of mice, causing a severe chronic hepatitis culminating in…”
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Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetate-treated Chinese hamster ovary cells by SHIAO, Y.-H, LEE, S.-H, KASPRZAK, K. S

“…Nickel(II) compounds are known human and animal carcinogens. In this study, the effects of nickel(II) acetate on cell cycle, apoptosis and p53 expression were…”
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Cadmium(II), unlike nickel(II), inhibits 8-oxo-dGTPase activity and increases 8-oxo-dG level in DNA of the rat testis, a target organ for cadmium(II) carcinogenesis by Bialkowski, Karol, Bialkowska, Aneta, Kasprzak, Kazimierz S.

“…8-Oxo-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) is an enzyme which prevents incorporation into DNA of promutagenic…”
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Expressions of hepatic genes, especially IGF-binding protein-1, correlating with serum corticosterone in microarray analysis by Cheng, RY, Birely, LA, Lum, NL, Perella, CM, Cherry, JM, Bhat, NK, Kasprzak, KS, Powell, DA, Alvord, WG, Anderson, LM

“…Microarray technology was evaluated for usefulness in assessing relationships between serum corticosterone and hepatic gene expression. Nine pairs of female…”
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Regulation of hypoxia-inducible genes by ETS1 transcription factor by Salnikow, Konstantin, Aprelikova, Olga, Ivanov, Sergey, Tackett, Sean, Kaczmarek, Monika, Karaczyn, Aldona, Yee, Herman, Kasprzak, Kazimierz S., Niederhuber, John

“…Hypoxia-inducible factor (HIF-1) regulates the expression of genes that facilitate tumor cell survival by making them more resistant to therapeutic…”
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Stray Cu(II) May Cause Oxidative Damage When Coordinated to the -TESHHK- Sequence Derived from the C-Terminal Tail of Histone H2A by Mylonas, Marios, Malandrinos, Gerasimos, Plakatouras, John, Hadjiliadis, Nick, Kasprzak, Kazimierz S, Krȩżel, Artur, Bal, Wojciech

“…CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a hexapeptide representing the 120−125 sequence of histone H2A, coordinates Cu(II) ions efficiently. Monomeric complexes are…”
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Induction of a Secondary Structure in the N-Terminal Pentadecapeptide of Human Protamine HP2 through Ni(II) Coordination. An NMR Study by Bal, Wojciech, Wójcik, Jacek, Maciejczyk, Maciej, Grochowski, Paweł, Kasprzak, Kazimierz S

“…A solution structure of the Ni(II) complex with the N-terminal pentadecapeptide of human protamine HP2 (HP21 - 15) was elucidated with the use of a range of…”
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Preconception Urethane or Chromium(III) Treatment of Male Mice: Multiple Neoplastic and Non-neoplastic Changes in Offspring by Yu, Wei, Sipowicz, Marek A., Haines, Diana C., Birely, Lisa, Diwan, Bhalchandra A., Riggs, Charles W., Kasprzak, Kazimierz S., Anderson, Lucy M.

“…Increase in neoplasia in offspring after preconception exposure of parents presents puzzling features such as high frequency of effects and lack of Mendelian…”
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Ascorbate Depletion: A Critical Step in Nickel Carcinogenesis? by Salnikow, Konstantin, Kasprzak, Kazimierz S.

“…Nickel compounds are known to cause respiratory cancer in humans and induce tumors in experimental animals. The underlying molecular mechanisms may involve…”
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Promotion of dimethylbenz[a]anthracene-initiated mammary carcinogenesis by iron in female Sprague-Dawley rats by DIWAN, B. A, KASPRZAK, K. S, ANDERSON, L. M

“…Iron body-stores and iron dietary intake have been sporadically reported to increase the risk of cancer in humans. To investigate the effect of iron on the…”
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Induction of oxidative DNA damage by carcinogenic metals by Bal, Wojciech, Kasprzak, Kazimierz S.

“…The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also include Co, Cu, Fe and Pt. A range of molecular mechanisms was…”
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Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats by KASPRZAK, K. S, JARUGA, P, ZASTAWNY, T. H, NORTH, S. L, RIGGS, C. W, OLINSKI, R, DIZDAROGLU, M

“…DNA base damage was assayed using gas chromatography/ mass spectrometry with selected ion monitoring (GC/MS-SIM) in renal and hepatic chromatin of male F344…”
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Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium by KASPRZAK, K. S, NAKABEPPU, Y, KAKUMA, T, SAKAI, Y, TSURUYA, K, SEKIGUCHI, M, WARD, J. M, DIWAN, B. A, NAGASHIMA, K, KASPRZAK, B. H

“…Cellular distribution of the antimutagenic MTH1protein in the liver, kidney, and testis of Fischer rat was evaluated using the immunohistochemical staining…”
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Generation of free radicals from hydrogen peroxide and lipid hydroperoxides in the presence of Cr(III) by Shi, X, Dalal, N S, Kasprzak, K S

“…Free radical generation from H2O2 and lipid hydroperoxides in the presence of Cr(III) was investigated by electron spin resonance (ESR) spin trapping…”
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Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II) by PORTER, D. W, YAKUSHIJI, H, NAKABEPPU, Y, SEKIGUCHI, M, FIVASH, M. J, KASPRZAK, K. S

“…The toxicity of Ni(II), Co(II) and Cu(II) in animals, and that of Cd(II) in cultured cells, has been associated with generation of the promutagenic lesion…”
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Enhancement by L-histidine of nickel(II)-induced DNA-protein cross-linking and oxidative DNA base damage in the rat kidney by Misra, Manoj, Olinski, Ryszard, Dizdaroglu, Miral, Kasprzak, Kazimierz S

“…Formation of DNA-protein cross-links and oxidatively damaged DNA bases was investigated with the use of alkaline elution and gas chromatography/mass…”
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