Search Results - "KASPAR, Manuela"

The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and Metastases by RYBAK, Jascha-N, ROESLI, Christoph, KASPAR, Manuela, VILLA, Alessandra, NERI, Dario

“…One of the most promising new avenues for the development of more selective and efficacious cancer therapies relies on the antibody-mediated targeted delivery…”
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Paclitaxel Enhances Therapeutic Efficacy of the F8-IL2 Immunocytokine to EDA-Fibronectin―Positive Metastatic Human Melanoma Xenografts by MOSCHETTA, Michele, PRETTO, Francesca, KASPAR, Manuela, TRACHSEL, Eveline, KOSMEHL, Hartwig, ROSA BANI, Maria, NERI, Dario, GIAVAZZI, Raffaella, BERNDT, Alexander, GALLER, Kerstin, RICHTER, Petra, BASSI, Andrea, OLIVA, Paolo, MICOTTI, Edoardo, VALBUSA, Giovanni, SCHWAGER, Kathrin

“…The selective delivery of bioactive agents to tumors reduces toxicity and enhances the efficacy of anticancer therapies. In this study, we show that the…”
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Antibody-Mediated Delivery of Interleukin-2 to the Stroma of Breast Cancer Strongly Enhances the Potency of Chemotherapy by MARLIND, Jessica, KASPAR, Manuela, TRACHSEL, Eveline, SOMMAVILLA, Roberto, HINDLE, Stuart, BACCI, Camilla, GIOVANNONI, Leonardo, NERI, Dario

“…Purpose: There is an interest in the discovery of biopharmaceuticals, which are well tolerated and which potentiate the action of anthracyclines and taxanes in…”
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Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis by Schwager, Kathrin, Kaspar, Manuela, Bootz, Frank, Marcolongo, Roberto, Paresce, Erberto, Neri, Dario, Trachsel, Eveline

“…In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice…”
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A Novel, Non-immunogenic Fyn SH3-derived Binding Protein with Tumor Vascular Targeting Properties by Grabulovski, Dragan, Kaspar, Manuela, Neri, Dario

“…The generation of novel binding molecules based on protein frameworks (“scaffolds”) represents an emerging field in protein engineering, with the potential to…”
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In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno―Positron Emission Tomography by MUMPRECHT, Viviane, HONER, Michael, VIGL, Benjamin, PROULX, Steven T, TRACHSEL, Eveline, KASPAR, Manuela, BANZIGER-TOBLER, Nadja E, SCHIBLI, Roger, NERI, Dario, DETMAR, Michael

“…Metastasis to regional lymph nodes (LN) is a prognostic indicator for cancer progression. There is a great demand for sensitive and noninvasive methods to…”
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The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis by Kaspar, Manuela, Trachsel, Eveline, Neri, Dario

“…Tumor-targeting immunocytokines represent a new class of anticancer pharmaceutical agents, which often display a superior therapeutic index compared with the…”
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Fibronectin as target for tumor therapy by Kaspar, Manuela, Zardi, Luciano, Neri, Dario

“…During cancer progression, the extracellular matrix (ECM) of the tissue in which the tumor grows is extensively remodeled, both by degradation of preexisting…”
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The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model by Schwager, Kathrin, Bootz, Frank, Imesch, Patrick, Kaspar, Manuela, Trachsel, Eveline, Neri, Dario

“…BACKGROUND Endometriosis is still a highly underdiagnosed disease, and the current medical and surgical treatment of endometriosis is associated with a high…”
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A high‐affinity human monoclonal antibody specific to the alternatively spliced EDA domain of fibronectin efficiently targets tumor neo‐vasculature in vivo by Villa, Alessandra, Trachsel, Eveline, Kaspar, Manuela, Schliemann, Christoph, Sommavilla, Roberto, Rybak, Jascha‐N., Rösli, Christoph, Borsi, Laura, Neri, Dario

“…The alternatively spliced extra‐domain B of fibronectin is one of the best characterized markers of tumor angiogenesis. Similarly, the extra‐domain A (EDA),…”
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Complete eradication of human B-cell lymphoma xenografts using rituximab in combination with the immunocytokine L19-IL2 by Schliemann, Christoph, Palumbo, Alessandro, Zuberbühler, Kathrin, Villa, Alessandra, Kaspar, Manuela, Trachsel, Eveline, Klapper, Wolfram, Menssen, Hans Dietrich, Neri, Dario

“…The antibody-mediated delivery of therapeutic agents to sites of angiogenesis is an attractive strategy for anticancer therapy, but is largely unexplored in…”
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A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma by EIGENTLER, Thomas K, WEIDE, Benjamin, LOVATO, Valeria, KASPAR, Manuela, TRACHSEL, Eveline, MENSSEN, Hans D, NERI, Dario, GARBE, Claus, DE BRAUD, Filippo, SPITALERI, Gianluca, ROMANINI, Antonella, PFLUGFELDER, Annette, GONZALEZ-LGLESIAS, Reinerio, TASCIOTTI, Annaelisa, GIOVANNONI, Leonardo, SCHWAGER, Kathrin

“…L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor angiogenesis marker, and of human…”
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The tumour-targeting human L19-IL2 immunocytokine: Preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with advanced renal cell carcinoma by Johannsen, Manfred, Spitaleri, Gianluca, Curigliano, Giuseppe, Roigas, Jan, Weikert, Steffen, Kempkensteffen, Carsten, Roemer, Andreas, Kloeters, Christian, Rogalla, Patrik, Pecher, Gabriele, Miller, Kurt, Berndt, Alexander, Kosmehl, Hartwig, Trachsel, Eveline, Kaspar, Manuela, Lovato, Valeria, González-Iglesias, Reinerio, Giovannoni, Leonardo, Menssen, Hans D, Neri, Dario, de Braud, Filippo

“…Abstract Background L19-IL2, a tumour-targeting immunocytokine composed of the recombinant human antibody fragment L19 (specific to the alternatively-spliced…”
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Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis by Trachsel, Eveline, Bootz, Frank, Silacci, Michela, Kaspar, Manuela, Kosmehl, Hartwig, Neri, Dario

“…The antibody-mediated targeted delivery of cytokines to sites of disease is a promising avenue for cancer therapy, but it is largely unexplored for the…”
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Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12 by Sommavilla, Roberto, Pasche, Nadine, Trachsel, Eveline, Giovannoni, Leonardo, Roesli, Christoph, Villa, Alessandra, Neri, Dario, Kaspar, Manuela

“…Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically associated with severe…”
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A Human mAb Specific to Oncofetal Fibronectin Selectively Targets Chronic Skin Inflammation In Vivo by Trachsel, Eveline, Kaspar, Manuela, Bootz, Frank, Detmar, Michael, Neri, Dario

“…The antibody-based targeted delivery of bioactive agents to sites of angiogenesis is an attractive therapeutic strategy for cancer treatment, but is largely…”
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Engineered vascular‐targeting antibody‐interferon‐γ fusion protein for cancer therapy by Ebbinghaus, Christina, Ronca, Roberto, Kaspar, Manuela, Grabulovski, Dragan, Berndt, Alexander, Kosmehl, Hartwig, Zardi, Luciano, Neri, Dario

“…A number of cytokines are either approved drugs or are in advanced clinical trials, yet these biopharmaceuticals do not typically localize efficiently in solid…”
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The antibody-mediated targeted delivery of interleukin-I0 inhibits endometriosis in a syngeneic mouse model by SCHWAGER, Kathrin, BOOTZ, Frank, IMESCH, Patrick, KASPAR, Manuela, TRACHSEL, Eveline, NERI, Dario

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The antibody-mediated targeted delivery of lnterleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis by KASPAR, Manuela, TRACHSEL, Eveline, NERI, Dario

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A general method for the selection of high-level scFv and IgG antibody expression by stably transfected mammalian cells by Zuberbühler, Kathrin, Palumbo, Alessandro, Bacci, Camilla, Giovannoni, Leonardo, Sommavilla, Roberto, Kaspar, Manuela, Trachsel, Eveline, Neri, Dario

“…The isolation of mammalian cell lines capable of high-yield expression of recombinant antibodies is typically performed by screening multiple individual clones…”
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