Search Results - "KASHI JAVAHERIAN"

Inhibition of Plaque Neovascularization Reduces Macrophage Accumulation and Progression of Advanced Atherosclerosis by Moulton, Karen S., Vakili, Khashayar, Zurakowsk, David, Soliman, Mohsin, Butterfield, Catherine, Sylvin, Erik, Lo, Kin-Ming, Gillies, Stephen, Javaherian, Kashi, Folkman, Judah

“…Plaque angiogenesis promotes the growth of atheromas, but the functions of plaque capillaries are not fully determined. Neovascularization may act as a conduit…”
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HSPG-binding peptide corresponding to the exon 6a-encoded domain of VEGF inhibits tumor growth by blocking angiogenesis in murine model by Lee, Tong-Young, Folkman, Judah, Javaherian, Kashi

“…Vascular endothelial growth factor VEGF(165) is a critical element for development of the vascular system in physiological and pathological angiogenesis. VEGF…”
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Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice by Bergers, Gabriele, Javaherian, Kashi, Lo, Kin-Ming, Folkman, Judah, Hanahan, Douglas

“…Solid tumors depend on angiogenesis for their growth. In a transgenic mouse model of pancreatic islet cell carcinogenesis (RIP1-Tag2), an angiogenic switch…”
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Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition by Sunshine, Sarah B, Dallabrida, Susan M, Durand, Ellen, Ismail, Nesreen S, Bazinet, Lauren, Birsner, Amy E, Sohn, Regina, Ikeda, Sadakatsu, Pu, William T, Kulke, Matthew H, Javaherian, Kashi, Zurakowski, David, Folkman, Judah M, Rupnick, Maria

“…Antiangiogenesis therapy has become a vital part of the armamentarium against cancer. Hypertension is a dose-limiting toxicity for VEGF inhibitors. Thus, there…”
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Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins by Lee, Tong-Young, Muschal, Stefan, Pravda, Elke A., Folkman, Judah, Abdollahi, Amir, Javaherian, Kashi

“…Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous antiangiogenic agent. The molecular mechanisms governing angiostatin's…”
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A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity by TJIN THAM SJIN, Robert M, SATCHI-FAINARO, Ronit, BIRSNER, Amy E, SADAGOPA RAMANUJAM, V. M, FOLKMAN, Judah, JAVAHERIAN, Kashi

“…The first recombinant endostatin that elicited strong antitumor activity was expressed in Escherichia coli and administered as a suspension. Under these…”
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Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy by LEE, Tong-Young, SJIN, Robert M. Tjintham, MOVAHEDI, Shahla, AHMED, Bissan, PRAVDA, Elke A, LO, Kin-Ming, GILLIES, Stephen D, FOLKMAN, Judah, JAVAHERIAN, Kashi

“…Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade…”
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Two Endogenous Antiangiogenic Inhibitors, Endostatin and Angiostatin, Demonstrate Biphasic Curves in their Antitumor Profiles by Javaherian, Kashi, Lee, Tong-Young, Sjin, Robert M. Tjin Tham, Parris, George E., Hlatky, Lynn

“…Angiogenesis refers to growth of blood vessels from pre-existing ones. In 1971, Folkman proposed that by choking off the blood supply to tumors, they are…”
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Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis by Zeng, Xiaokun, Chen, Joshua, Miller, Yury I, Javaherian, Kashi, Moulton, Karen S

“…Retention of lipoproteins to proteoglycans in the subendothelial matrix (SEM) is an early event in atherosclerosis. We recently reported that collagen XVIII…”
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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis by Stark, Walter J., Brem, Henry, Daoud, Yassine J., Grossman, Rachel, Javaherian, Kashi, Tyler, Betty, Zambrano, Andrea I., Wicks, Robert T., Yoshida, Junko, Gehlbach, Peter L.

“…We assessed the antiangiogenic effects of subconjunctival injection of Fc-endostatin (FcE) using a human vascular endothelial growth factor-induced rabbit…”
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Zinc-Dependent Dimers Observed in Crystals of Human Endostatin by Ding, Yuan-Hua, Javaherian, Kashi, Lo, Kin-Ming, Chopra, Rajiv, Boehm, Thomas, Lanciotti, Julia, Harris, B. A., Li, Yue, Shapiro, Robert, Hohenester, Erhard, Timpl, Rupert, Folkman, Judah, Wiley, Don C.

“…The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and…”
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Laminin Modulates Morphogenic Properties of the Collagen XVIII Endostatin Domain by Javaherian, Kashi, Park, Susan Y, Pickl, Winfried F, LaMontagne, Kenneth R, Sjin, Robert Tjin Tham, Gillies, Stephen, Lo, Kin-Ming

“…We have shown previously that the oligomeric endostatin domain of collagen XVIII (NC1) functioned as a motility-inducing factor regulating the extracellular…”
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The Morphogenic Properties of Oligomeric Endostatin Are Dependent on Cell Surface Heparan Sulfate by Clamp, Andrew, Blackhall, Fiona H., Henrioud, Audrey, Jayson, Gordon C., Javaherian, Kashi, Esko, Jeff, Gallagher, John T., Merry, Catherine L.R.

“…Endostatin has attracted considerable attention because of its ability to inhibit angiogenesis. This property of monomeric endostatin contrasts with that of…”
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Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1 by Javaherian, Kashi, Langlois, Alphonse J., LaRosa, Greg J., Profy, Albert T., Bolognesi, Dani P., Herlihy, Walter C., Putney, Scott D., Matthews, Thomas J.

“…The principal neutralizing determinant (PND) of human immunodeficiency virus (HIV)-1 resides within the V$_3$ loop of the envelope protein. Antibodies elicited…”
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Antibodies that Inhibit Fusion of Human Immunodeficiency Virus-Infected Cells Bind a 24-amino Acid Sequence of the Viral Envelope, gp120 by Rusche, James R., Javaherian, Kashi, McDanal, Charlene, Petro, Joan, Lynn, Debra L., Grimaila, Raymond, Langlois, Alphonse, Gallo, Robert C., Arthur, Larry O., Fischinger, Peter J., Bolognesi, Dani P., Putney, Scott D., Matthews, Thomas J.

“…Antisera to recombinant human immunodeficiency virus (HIV) proteins containing the entire envelope, gp160, or the central portion of the envelope, PB1, can…”
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Random copolymers containing specific ratios of negatively charged and aromatic amino acids bind V3 disulfide loop and neutralize diverse HIV type 1 isolates by Javaherian, K, McDanal, C

“…Random copolymers of polyamino acids containing negatively charged and aromatic residues at specific ratios appear to bind HIV type 1 V3 loop and neutralize…”
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Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein by Skinner, M A, Ting, R, Langlois, A J, Weinhold, K J, Lyerly, H K, Javaherian, K, Matthews, T J

“…We have studied the biologic and physical properties of a monoclonal antibody that binds to gp120, the exterior envelope glycoprotein of the human…”
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Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin: Laboratory investigation by GROSSMAN, Rachel, TYLER, Betty, HWANG, Lee, ZADNIK, Patti, LAL, Bachchu, JAVAHERIAN, Kashi, BREM, Henry

“…Object Brain tumors pose many unique challenges to treatment. The authors hypothesized that Fc-endostatin may be beneficial. It is a newly synthesized…”
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Neutralizing monoclonal antibody against a external envelope glycoprotein (gp110) of SIVmac251 by Matsumi, S, Matsushita, S, Yoshimura, K, Javaherian, K, Takatsuki, K

“…Three monoclonal antibodies (M318T, M56S and M815) against an external envelope glycoprotein (gp110) of simian immunodeficiency virus (SIV) mac251 were…”
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Immune responses induced by prototype vaccines for AIDS in rhesus monkeys by Ohkawa, S, Wilson, L A, Larosa, G, Javaherian, K, Martin, L N, Murphey-Corb, M

“…A battery of assay systems was used to profile both humoral and cell-mediated immune responses induced by immunization with candidate vaccines consisting of…”
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