Search Results - "KASHI, Rina"

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor by Kaye, Joel, Piryatinsky, Victor, Birnberg, Tal, Hingaly, Tal, Raymond, Emanuel, Kashi, Rina, Amit-Romach, Einat, Caballero, Ignacio S., Towfic, Fadi, Ator, Mark A., Rubinstein, Efrat, Laifenfeld, Daphna, Orbach, Aric, Shinar, Doron, Marantz, Yael, Grossman, Iris, Knappertz, Volker, Hayden, Michael R., Laufer, Ralph

“…Laquinimod is an oral drug currently being evaluated for the treatment of relapsing, remitting, and primary progressive multiple sclerosis and Huntington’s…”
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Treatment of resistant human colon cancer xenografts by a fluoxetine–doxorubicin combination enhances therapeutic responses comparable to an aggressive bevacizumab regimen by Argov, Mirit, Kashi, Rina, Peer, Dan, Margalit, Rimona

“…Abstract Pre-clinical studies of multidrug resistance (MDR) usually address severe resistance, yet moderate MDR is already clinically-impeding. The purpose of…”
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Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts by BLUMENTHAL, R. D, SHARKEY, R. M, NATALE, A. M, RINA KASHI, WONG, G, GOLDENBERG, D. M

“…The therapeutic efficacy of 5-fluorouracil (5-FUra; 0.6 mg/day x 5 days) + leucovorin (LV; 1.8 mg/day x 5 days) and of 131I-labeled MN-14 anticarcinoembryonic…”
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Quantitative and qualitative effects of experimental radioimmunotherapy on tumor vascular permeability by Blumenthal, R D, Kashi, R, Sharkey, R M, Goldenberg, D M

“…Localization of radiolabeled antibodies in the perivascular space of tumors resulted in morphological changes in blood vessel structure and physiological…”
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Abstract 819: A novel small molecule cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to treatment with gemcitabine by Yang, Mi Young, Lee, Young Bok, Kim, Deog Joong, Ahn, Chang-Ho, Kaye, Joel, Fine, Tania, Kashi, Rina, Ohne, Osnat

“…Abstract RX-3117 (fluorocyclopentenylcytosine) is a novel small-molecule chemotherapeutic agent that belongs to the class of cytotoxic antimetabolite cytidine…”
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A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine by Yang, Mi Young, Lee, Young Bok, Ahn, Chang-Ho, Kaye, Joel, Fine, Tania, Kashi, Rina, Ohne, Osnat, Smid, Kees, Peters, Godefridus J, Kim, Deog Joong

“…RX-3117 (fluorocyclopentenylcytosine) is a cytidine analog and this class of drugs, including gemcitabine, has been widely used for the treatment of various…”
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N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824) by Remiszewski, Stacy W, Sambucetti, Lidia C, Bair, Kenneth W, Bontempo, John, Cesarz, David, Chandramouli, Nagarajan, Chen, Ru, Cheung, Min, Cornell-Kennon, Susan, Dean, Karl, Diamantidis, George, France, Dennis, Green, Michael A, Howell, Kobporn Lulu, Kashi, Rina, Kwon, Paul, Lassota, Peter, Martin, Mary S, Mou, Yin, Perez, Lawrence B, Sharma, Sushil, Smith, Troy, Sorensen, Eric, Taplin, Francis, Trogani, Nancy, Versace, Richard, Walker, Heather, Weltchek-Engler, Susan, Wood, Alexander, Wu, Arthur, Atadja, Peter

“…A series of N-hydroxy-3-phenyl-2-propenamides were prepared as novel inhibitors of human histone deacetylase (HDAC). These compounds were potent enzyme…”
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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]-phen yl]-2-propenamide (NVP-LAQ824) by REMISZEWSKI, Stacy W, SAMBUCETTI, Lidia C, DIAMANTIDIS, George, FRANCE, Dennis, GREEN, Michael A, HOWELL, Kobporn Lulu, KASHI, Rina, KWON, Paul, LASSOTA, Peter, MARTIN, Mary S, YIN MOU, PEREZ, Lawrence B, BAIR, Kenneth W, SHARMA, Sushil, SMITH, Troy, SORENSEN, Eric, TAPLIN, Francis, TROGANI, Nancy, VERSACE, Richard, WALKER, Heather, WELTCHEK-ENGLER, Susan, WOOD, Alexander, WU, Arthur, BONTEMPO, John, ATADJA, Peter, CESARZ, David, CHANDRAMOULI, Nagarajan, RU CHEN, MIN CHEUNG, CORNELL-KENNON, Susan, DEAN, Karl

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The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies : an autoradiographic study by BLUMENTHAL, R. D, FAND, I, SHARKEY, R. M, BOERMAN, O. C, KASHI, R, GOLDENBERG, D. M

“…The inaccessibility of radiolabeled antibody to poorly vascularized regions of solid tumors may reduce the therapeutic efficacy of these macromolecules…”
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Changes in tumor vascular permeability in response to experimental radioimmunotherapy: a comparative study of 11 xenografts by Blumenthal, R D, Sharkey, R M, Kashi, R, Sides, K, Stein, R, Goldenberg, D M

“…Single and fractionated doses of radioimmunotherapy (RAIT) and standard chemotherapy (0.6 mg 5-FU/day and 0.36 leucovorin/day on days 1-5) result in decreases…”
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Physiological factors influencing radioantibody uptake: a study of four human colonic carcinomas by Blumenthal, R D, Sharkey, R M, Kashi, R, Natale, A M, Goldenberg, D M

“…We evaluated the accretion of 131I-labeled NP-4 anticarcinoembryonic antigen (CEA) into 4 size-matched human colonic carcinomas grown s.c. in nude mice…”
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Improved radioimmunotherapy of colorectal cancer xenografts using antibody mixtures against carcinoembryonic antigen and colon-specific antigen-p by BLUMENTHAL, R. D, KASHI, R, STEPHENS, R, SHARKEY, R. M, GOLDENBERG, D. M

“…Radioimmunotherapy of GW-39 human colonic tumor xenografts grown in the hamster cheek pouch with 131I-labeled NP-4 anti-(carcinoembryonic antigen) (CEA) and…”
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The covalent linking of two nucleotide analogs to antibodies by Hurwitz, Esther, Kashi, Rina, Arnon, Ruth, Wilchek, Meir, Sela, Michael

“…Two anticancer drugs, antagonists of nucleic acids, were covalently linked to antibodies specifically reactive with B leukemia cells and thus with a potential…”
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Chemotherapy by Intravenous Administration of Conjugates of Daunomycin with Monoclonal and Conventional Anti-Rat α -fetoprotein Antibodies by Tsukada, Yutaka, Hurwitz, Esther, Kashi, Rina, Sela, Michael, Hibi, Nozomu, Hara, Akihiko, Hirai, Hidematsu

“…Monoclonal antibodies to rat α -fetoprotein (AFP) were produced by hybridization of mouse myeloma cells with spleen cells from mice immunized with rat AFP. The…”
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Comparison of therapeutic efficacy and host toxicity of two different 131I-labelled antibodies and their fragments in the GW-39 colonic cancer xenograft model by Blumenthal, R D, Sharkey, R M, Kashi, R, Goldenberg, D M

“…The in vivo uptake, therapeutic potential, and host toxicity were evaluated for both the intact IgG and F(ab')2 fragment of 2 murine monoclonal antibodies…”
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Site-directed chemotherapy with a drug bound to anti-idiotypic antibody to a lymphoma cell-surface IgM by Hurwitz, E, Kashi, R, Burowsky, D, Arnon, R, Haimovich, J

“…Xenogeneic antibodies against the cell-surface IgM of a B-cell lymphoma (38C-13) were coupled through a dextran bridge to the anti-neoplastic drug, daunomycin…”
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Platinum-complexed antitumor immunoglobulins that specifically inhibit DNA synthesis of mouse tumor cells by Hurwitz, E, Kashi, R, Wilchek, M

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Suppression of tumor vascular activity by radioantibody therapy: implications for multiple cycle treatments by Blumenthal, R D, Sharkey, R M, Kashi, R, Goldenberg, D M

“…Autoradiographic analysis of the intratumor location of radioiodinated Mu-9 anti-CSAp antibody within 7 days of administration reveals a restricted…”
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Effect of a conjugate of daunomycin and purified polyclonal or monoclonal antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells by Tsukada, Y, Hurwitz, E, Kashi, R, Sela, M, Hibi, N, Hara, A, Hirai, H

“…Monoclonal antibodies to rat alpha-fetoprotein (AFP) were produced by hybridization of mouse myeloma cells with spleen cells from mice immunized with rat AFP…”
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