Search Results - "KASHENTSEVA, Elena"

Efficient Genome Editing Achieved via Plug-and-Play Adenovirus Piggyback Transport of Cas9/gRNA Complex on Viral Capsid Surface by Lu, Zhi Hong, Li, Jie, Dmitriev, Igor P., Kashentseva, Elena A., Curiel, David T.

“…The capacity to efficiently deliver the gene-editing enzyme complex to target cells is favored over other forms of gene delivery as it offers one-time…”
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Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Lauron, Elvin J., Kashentseva, Elena, Lu, Zhi Hong, Yokoyama, Wayne M., Curiel, David T.

“…Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting…”
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Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Kashentseva, Elena, Everett, William, Kaliberova, Lyudmila, Curiel, David T.

“…Serum deficiency diseases such as alpha-1-antitrypsin deficiency are characterized by reduced function of serum proteins, caused by deleterious genetic…”
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice by Hassan, Ahmed O., Shrihari, Swathi, Gorman, Matthew J., Ying, Baoling, Yaun, Dansu, Raju, Saravanan, Chen, Rita E., Dmitriev, Igor P., Kashentseva, Elena, Adams, Lucas J., Mann, Colin, Davis-Gardner, Meredith E., Suthar, Mehul S., Shi, Pei-Yong, Saphire, Erica Ollmann, Fremont, Daved H., Curiel, David T., Alter, Galit, Diamond, Michael S.

“…SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally…”
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Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection by Ying, Baoling, Darling, Tamarand L., Desai, Pritesh, Liang, Chieh-Yu, Dmitriev, Igor P., Soudani, Nadia, Bricker, Traci, Kashentseva, Elena A., Harastani, Houda, Raju, Saravanan, Liu, Meizi, Schmidt, Aaron G., Curiel, David T., Boon, Adrianus C. M., Diamond, Michael S.

“…A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used…”
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Adenovirus platform enhances transduction efficiency of human mesenchymal stem cells: An opportunity for cellular carriers of targeted TRAIL-based TR3 biologics in ovarian cancer by Kuroki, Lindsay M, Jin, Xingjian, Dmitriev, Igor P, Kashentseva, Elena A, Powell, Matthew A, Mutch, David G, Dietz, Allan B, Curiel, David T, Hawkins, William G, Spitzer, Dirk

“…Clinical application of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based cancer therapeutics has not reached optimal potencies in part due…”
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Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein by Mukherjee, Jean, Dmitriev, Igor, Debatis, Michelle, Tremblay, Jacqueline M, Beamer, Gillian, Kashentseva, Elena A, Curiel, David T, Shoemaker, Charles B

“…Current therapies for most acute toxin exposures are limited to administration of polyclonal antitoxin serum. We have shown that VHH-based neutralizing agents…”
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Author Correction: Mucosal vaccine-induced cross-reactive CD8+ T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection by Ying, Baoling, Darling, Tamarand L., Desai, Pritesh, Liang, Chieh-Yu, Dmitriev, Igor P., Soudani, Nadia, Bricker, Traci, Kashentseva, Elena A., Harastani, Houda, Raju, Saravanan, Liu, Meizi, Schmidt, Aaron G., Curiel, David T., Boon, Adrianus C. M., Diamond, Michael S.

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Adenoviral vectors infect B lymphocytes in vivo by Rice-Boucher, Paul J., Mendonça, Samir Andrade, Alvarez, Aluet Borrego, Sturtz, Alexandria J., Lorincz, Reka, Dmitriev, Igor P., Kashentseva, Elena A., Lu, Zhi Hong, Romano, Rosa, Selby, Mark, Pingale, Kunal, Curiel, David T.

“…B cells are the antibody-producing arm of the adaptive immune system and play a critical role in controlling pathogens. Several groups have now demonstrated…”
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A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy by Hassan, Ahmed O., Dmitriev, Igor P., Kashentseva, Elena A., Zhao, Haiyan, Brough, Douglas E., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla…”
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A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting by Lu, Zhi Hong, Dmitriev, Igor P, Brough, Douglas E, Kashentseva, Elena A, Li, Jie, Curiel, David T

“…Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in…”
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Engineering a Novel Modular Adenoviral mRNA Delivery Platform Based on Tag/Catcher Bioconjugation by Geng, Kexin, Rice-Boucher, Paul J, Kashentseva, Elena A, Dmitriev, Igor P, Lu, Zhi Hong, Goedegebuure, S Peter, Gillanders, William E, Curiel, David T

“…mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for…”
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Retraction Notice to: Insulin-like Growth Factor-binding Protein-7 (IGFBP7): A Promising Gene Therapeutic for Hepatocellular Carcinoma (HCC) by Chen, Dong, Siddiq, Ayesha, Emdad, Luni, Rajasekaran, Devaraja, Gredler, Rachel, Shen, Xue-Ning, Santhekadur, Prasanna K., Srivastava, Jyoti, Robertson, Chadia L., Dmitriev, Igor, Kashentseva, Elena A., Curiel, David T., Fisher, Paul B., Sarkar, Devanand

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Targeting Tumor Neoangiogenesis via Targeted Adenoviral Vector to Achieve Effective Cancer Gene Therapy for Disseminated Neoplastic Disease by Lee, Myungeun, Lu, Zhi Hong, Li, Jie, Kashentseva, Elena A, Dmitriev, Igor P, Mendonca, Samir A, Curiel, David T

“…The application of cancer gene therapy has heretofore been restricted to local, or locoregional, neoplastic disease contexts. This is owing to the lack of gene…”
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A Plasmodium Promiscuous T Cell Epitope Delivered within the Ad5 Hexon Protein Enhances the Protective Efficacy of a Protein Based Malaria Vaccine by Fonseca, Jairo Andres, Cabrera-Mora, Monica, Kashentseva, Elena A, Villegas, John Paul, Fernandez, Alejandra, Van Pelt, Amelia, Dmitriev, Igor P, Curiel, David T, Moreno, Alberto

“…A malaria vaccine is a public health priority. In order to produce an effective vaccine, a multistage approach targeting both the blood and the liver stage…”
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Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody by Lee, Myungeun, Lu, Zhi Hong, Shoemaker, Charles B., Tremblay, Jacqueline M., St. Croix, Bradley, Seaman, Steven, Gonzalez-Pastor, Rebeca, Kashentseva, Elena A., Dmitriev, Igor P., Curiel, David T.

“…For the developing field of gene therapy the successful address of the basic requirement effective gene delivery has remained a critical barrier. In this…”
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A phase I clinical trial of Ad5/3-Δ24, a novel serotype-chimeric, infectivity-enhanced, conditionally-replicative adenovirus (CRAd), in patients with recurrent ovarian cancer by Kim, Kenneth H, Dmitriev, Igor P, Saddekni, Souheil, Kashentseva, Elena A, Harris, Raymond D, Aurigemma, Rosemarie, Bae, Sejong, Singh, Karan P, Siegal, Gene P, Curiel, David T, Alvarez, Ronald D

“…Abstract Objective The conditionally replicative adenovirus Ad5/3-Δ24 has a type-3 knob incorporated into the type-5 fiber that facilitates enhanced ovarian…”
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Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates by Gagne, Matthew, Flynn, Barbara J., Andrew, Shayne F., Marquez, Josue, Flebbe, Dillon R., Mychalowych, Anna, Lamb, Evan, Davis-Gardner, Meredith E., Burnett, Matthew R., Serebryannyy, Leonid A., Lin, Bob C., Ziff, Zohar E., Maule, Erin, Carroll, Robin, Naisan, Mursal, Jethmalani, Yogita, Pessaint, Laurent, Todd, John-Paul M., Doria-Rose, Nicole A., Case, James Brett, Dmitriev, Igor P., Kashentseva, Elena A., Ying, Baoling, Dodson, Alan, Kouneski, Katelyn, O’Dell, Sijy, Wali, Bushra, Ellis, Madison, Godbole, Sucheta, Laboune, Farida, Henry, Amy R., Teng, I-Ting, Wang, Danyi, Wang, Lingshu, Zhou, Qiong, Zouantchangadou, Serge, Van Ry, Alex, Lewis, Mark G., Andersen, Hanne, Kwong, Peter D., Curiel, David T., Roederer, Mario, Nason, Martha C., Foulds, Kathryn E., Suthar, Mehul S., Diamond, Michael S., Douek, Daniel C., Seder, Robert A.

“…A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit…”
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A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection by Schmidt, Diane J, Beamer, Gillian, Tremblay, Jacqueline M, Steele, Jennifer A, Kim, Hyeun Bum, Wang, Yaunkai, Debatis, Michele, Sun, Xingmin, Kashentseva, Elena A, Dmitriev, Igor P, Curiel, David T, Shoemaker, Charles B, Tzipori, Saul

“…Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly…”
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Development of an adenovirus vector vaccine platform for targeting dendritic cells by Sharma, Piyush K., Dmitriev, Igor P., Kashentseva, Elena A., Raes, Geert, Li, Lijin, Kim, Samuel W., Lu, Zhi-Hong, Arbeit, Jeffrey M., Fleming, Timothy P., Kaliberov, Sergey A., Goedegebuure, S. Peter, Curiel, David T., Gillanders, William E.

“…Adenoviral (Ad) vector vaccines represent one of the most promising modern vaccine platforms, and Ad vector vaccines are currently being investigated in human…”
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