Search Results - "KASAIAN, Marion"

IL-13 Controls IL-33 Activity through Modulation of ST2 by Zhang, Melvin, Duffen, Jennifer L., Nocka, Karl H., Kasaian, Marion T.

“…Abstract IL-33 is a multifunctional cytokine that mediates local inflammation upon tissue damage. IL-33 is known to act on multiple cell types including group…”
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IL-13 as a therapeutic target for respiratory disease by Kasaian, Marion T., Miller, Douglas K.

“…Interleukin-13 (IL-13) is a critical mediator of asthma pathology. On B cells, monocytes, epithelial cells, and smooth muscle cells, IL-13 acts through the…”
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Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma by Gauvreau, Gail M, Boulet, Louis-Philippe, Cockcroft, Donald W, Fitzgerald, J Mark, Carlsten, Chris, Davis, Beth E, Deschesnes, Francine, Duong, MyLinh, Durn, Billie L, Howie, Karen J, Hui, Linda, Kasaian, Marion T, Killian, Kieran J, Strinich, Tara X, Watson, Richard M, Y, Nathalie, Zhou, Simon, Raible, Donald, O'Byrne, Paul M

“…Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1) antibodies that…”
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Molecular and Functional Characterization of Human Intestinal Organoids and Monolayers for Modeling Epithelial Barrier by Jelinsky, Scott A, Derksen, Merel, Bauman, Eric, Verissimo, Carla S, van Dooremalen, Wies T M, Roos, Jamie Lee, Higuera Barón, Celia, Caballero-Franco, Celia, Johnson, Bryce G, Rooks, Michelle G, Pott, Johanna, Oldenburg, Bas, Vries, Robert G J, Boj, Sylvia F, Kasaian, Marion T, Pourfarzad, Farzin, Rosadini, Charles V

“…Abstract Background Patient-derived organoid (PDO) models offer potential to transform drug discovery for inflammatory bowel disease (IBD) but are limited by…”
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A platform to reproducibly evaluate human colon permeability and damage by Marr, Elizabeth E., Mulhern, Thomas J., Welch, Michaela, Keegan, Philip, Caballero-Franco, Celia, Johnson, Bryce G., Kasaian, Marion, Azizgolshani, Hesham, Petrie, Timothy, Charest, Joseph, Wiellette, Elizabeth

“…The intestinal epithelium comprises diverse cell types and executes many specialized functions as the primary interface between luminal contents and internal…”
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IL-13 Antibodies Influence IL-13 Clearance in Humans by Modulating Scavenger Activity of IL-13R alpha 2 by Kasaian, Marion T, Raible, Donald, Marquette, Kimberly, Cook, Timothy A, Zhou, Simon, Tan, Xiang-Yang, Tchistiakova, Lioudmila

“…Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on…”
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Modulation of the IL-33/IL-13 Axis in Obesity by IL-13Rα2 by Duffen, Jennifer, Zhang, Melvin, Masek-Hammerman, Katherine, Nunez, Angela, Brennan, Agnes, Jones, Jessica E C, Morin, Jeffrey, Nocka, Karl, Kasaian, Marion

“…In obesity, IL-13 overcomes insulin resistance by promoting anti-inflammatory macrophage differentiation in adipose tissue. Endogenous IL-13 levels can be…”
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Therapeutic activity of an interleukin‐4/interleukin‐13 dual antagonist on oxazolone‐induced colitis in mice by Kasaian, Marion T., Page, Karen M., Fish, Susan, Brennan, Agnes, Cook, Timothy A., Moreira, Karen, Zhang, Melvin, Jesson, Michael, Marquette, Kimberly, Agostinelli, Rita, Lee, Julie, Williams, Cara M. M., Tchistiakova, Lioudmila, Thakker, Paresh

“…Summary Interleukin‐4 (IL‐4) and IL‐13 are critical drivers of immune activation and inflammation in ulcerative colitis, asthma and other diseases. Because…”
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Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease by Karmele, Erik P., Pasricha, Trisha S., Ramalingam, Thirumalai R., Thompson, Robert W., Gieseck, Richard L., Knilans, Kayla J., Hegen, Martin, Farmer, Mark, Jin, Fang, Kleinman, Aaron, Hinds, David A., Almeida Pereira, Thiago, de Queiroz Prado, Rafael, Bing, Nan, Tchistiakova, Lioudmila, Kasaian, Marion T., Wynn, Thomas A., Vannella, Kevin M.

“…There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13…”
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The Progressive Multifocal Leukoencephalopathy Consortium as a Model for Advancing Research and Dialogue on Rare Severe Adverse Drug Reactions by Peterson, Ilse S., Iverson, William O., Kasaian, Marion T., Liu, Maggie

“…Progressive multifocal leukoencephalopathy (PML) is a rare but serious disease. Caused by the JC virus (JCV), it occurs in individuals with weakened immune…”
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IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2 by Kasaian, Marion T, Raible, Donald, Marquette, Kimberly, Cook, Timothy A, Zhou, Simon, Tan, Xiang-Yang, Tchistiakova, Lioudmila

“…Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on…”
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An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice by Kasaian, Marion T, Marquette, Kimberly, Fish, Susan, DeClercq, Charlene, Agostinelli, Rita, Cook, Timothy A, Brennan, Agnes, Lee, Julie, Fitz, Lori, Brooks, Jonathan, Vugmeyster, Yulia, Williams, Cara M M, Lofquist, Alan, Tchistiakova, Lioudmila

“…IL-4 and IL-13 comprise promising targets for therapeutic interventions in asthma and other Th2-associated diseases, but agents targeting either IL-4 or IL-13…”
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A mechanistic PK/PD model for two anti-IL13 antibodies explains the difference in total IL-13 accumulation observed in clinical studies by Tiwari, Abhinav, Kasaian, Marion, Heatherington, Anne C, Jones, Hannah M, Hua, Fei

“…IMA-638 and IMA-026 are humanized IgG1 monoclonal antibodies (mAbs) that target non-overlapping epitopes of IL-13. Separate first-in-human single ascending…”
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Mast Cell-Dependent Contraction of Human Airway Smooth Muscle Cell-Containing Collagen Gels: Influence of Cytokines, Matrix Metalloproteases, and Serine Proteases by Margulis, Alexander, Nocka, Karl H, Brennan, Agnes M, Deng, Bijia, Fleming, Margaret, Goldman, Samuel J, Kasaian, Marion T

“…In asthma, mast cells infiltrate the airway smooth muscle cell layer and secrete proinflammatory and profibrotic agents that contribute to airway remodeling…”
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IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys by Bree, Andrea, BS, Schlerman, Franklin J., BS, Wadanoli, Michael, DVM, Tchistiakova, Lioudmila, PhD, Marquette, Kimberly, BS, Tan, Xiang-Yang, MD, PhD, Jacobson, Bruce A., PhD, Widom, Angela, MS, Cook, Timothy A., BS, Wood, Nancy, BS, Vunnum, Suresh, PhD, Krykbaev, Rustem, PhD, Xu, Xin, PhD, Donaldson, Debra D., MD, Goldman, Samuel J., PhD, Sypek, Joseph, PhD, Kasaian, Marion T., PhD

“…Background Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer of airway inflammation in…”
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IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation: A Mediator of the Transition from Innate to Adaptive Immunity by Kasaian, Marion T, Whitters, Matthew J, Carter, Laura L, Lowe, Leslie D, Jussif, Jason M, Deng, Bijia, Johnson, Kaley A, Witek, JoAnn S, Senices, Mayra, Konz, Richard F, Wurster, Andrea L, Donaldson, Debra D, Collins, Mary, Young, Deborah A, Grusby, Michael J

“…IFNα/β, IL-12, and IL-15 regulate NK cell activation and expansion, but signals triggering resolution of the NK response upon induction of adaptive immunity…”
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IgE Generation and Mast Cell Effector Function in Mice Deficient in IL-4 and IL-13 by Fish, Susan C, Donaldson, Debra D, Goldman, Samuel J, Williams, Cara M. M, Kasaian, Marion T

“…IL-4 and IL-13 are potent cytokines that drive production of IgE, which is critical to the development of atopic disease. In this study, we directly compared…”
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MMP dependence of fibroblast contraction and collagen production induced by human mast cell activation in a three-dimensional collagen lattice by Margulis, Alexander, Nocka, Karl H, Wood, Nancy L, Wolf, Stanley F, Goldman, Samuel J, Kasaian, Marion T

“…Mast cell-fibroblast interactions may contribute to fibrosis in asthma and other disease states. Fibroblast contraction is known to be stimulated by coculture…”
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IL-21 effects on human IgE production in response to IL-4 or IL-13 by Wood, Nancy, Bourque, Karen, Donaldson, Debra D., Collins, Mary, Vercelli, Donata, Goldman, Samuel J., Kasaian, Marion T.

“…In human atopic disease, IgE sensitizes the allergic response, while IgG4 is protective. Because IL-4 and IL-13 trigger switch recombination to both IgE and…”
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Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys by Kasaian, Marion T, Tan, Xiang-Yang, Jin, Macy, Fitz, Lori, Marquette, Kimberly, Wood, Nancy, Cook, Timothy A, Lee, Julie, Widom, Angela, Agostinelli, Rita, Bree, Andrea, Schlerman, Franklin J, Olland, Stephane, Wadanoli, Michael, Sypek, Joseph, Gill, Davinder, Goldman, Samuel J, Tchistiakova, Lioudmila

“…Interleukin (IL)-13 is a key cytokine driving allergic and asthmatic responses and contributes to airway inflammation in cynomolgus monkeys after segmental…”
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