Search Results - "KARTSONIS, Nicholas A"

A Mortality Analysis of Letermovir Prophylaxis for Cytomegalovirus (CMV) in CMV-seropositive Recipients of Allogeneic Hematopoietic Cell Transplantation by Ljungman, Per, Schmitt, Michael, Marty, Francisco M, Maertens, Johan, Chemaly, Roy F, Kartsonis, Nicholas A, Butterton, Joan R, Wan, Hong, Teal, Valerie L, Sarratt, Kendra, Murata, Yoshihiko, Leavitt, Randi Y, Badshah, Cyrus

“…Abstract Background In a phase 3 trial, letermovir reduced clinically significant cytomegalovirus infections (CS-CMVi) and all-cause mortality at week 24…”
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Efficacy and Safety of Caspofungin for Treatment of Invasive Aspergillosis in Patients Refractory to or Intolerant of Conventional Antifungal Therapy by Maertens, Johan, Raad, Issam, Petrikkos, George, Boogaerts, Marc, Selleslag, Dominik, Petersen, Finn B., Sable, Carole A., Kartsonis, Nicholas A., Ngai, Angela, Taylor, Arlene, Patterson, Thomas F., Denning, David W., Walsh, Thomas J.

“…Background. Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised patients. Echinocandins are novel antifungal…”
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Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease by Cornely, Oliver A, Robertson, Michael N, Haider, Shariq, Grigg, Andrew, Geddes, Michelle, Aoun, Mickael, Heinz, Werner J, Raad, Issam, Schanz, Urs, Meyer, Ralf G, Hammond, Sarah P, Mullane, Kathleen M, Ostermann, Helmut, Ullmann, Andrew J, Zimmerli, Stefan, Van Iersel, M L P S, Hepler, Deborah A, Waskin, Hetty, Kartsonis, Nicholas A, Maertens, Johan

“…A two-part (Phase 1B/3), sequential, open-label, multicentre study evaluated the pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as…”
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A non-randomized trial to assess the safety, tolerability, and pharmacokinetics of posaconazole oral suspension in immunocompromised children with neutropenia by Arrieta, Antonio C, Sung, Lillian, Bradley, John S, Zwaan, C Michel, Gates, Davis, Waskin, Hetty, Carmelitano, Patricia, Groll, Andreas H, Lehrnbecher, Thomas, Mangin, Eric, Joshi, Amita, Kartsonis, Nicholas A, Walsh, Thomas J, Paschke, Amanda

“…Posaconazole (POS) is a potent triazole antifungal agent approved in adults for treatment and prophylaxis of invasive fungal infections (IFIs). The objectives…”
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A Multicenter, Double-Blind Trial of a High-Dose Caspofungin Treatment Regimen versus a Standard Caspofungin Treatment Regimen for Adult Patients with Invasive Candidiasis by Betts, Robert F., Nucci, Marcio, Talwar, Deepak, Gareca, Marcelo, Queiroz-Telles, Flavio, Bedimo, Roger J., Herbrecht, Raoul, Ruiz-Palacios, Guillermo, Young, Jo-Anne H., Baddley, John W., Strohmaier, Kim M., Tucker, Kimberly A., Taylor, Arlene F., Kartsonis, Nicholas A.

“…Background. The standard caspofungin treatment regimen (50 mg/day after a 70-mg dose on day 1) is effective and well tolerated for the treatment of invasive…”
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Pharmacokinetics and Safety of Caspofungin in Neonates and Infants Less than 3 Months of Age by SAEZ-LLORENS, Xavier, MACIAS, Mercedes, PENG SUN, STROHMAIER, Kim M, FALLON, Marissa, SHENG BI, STONE, Julie A, CHOW, Joseph W, MAIYA, Padmanabha, PINEROS, Juan, JAFRI, Hasan S, CHATTERJEE, Archana, RUIZ, Gloria, RAGHAVAN, Janaki, BRADSHAW, Susan K, KARTSONIS, Nicholas A

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The immunogenicity and safety of different formulations of a novel Staphylococcus aureus vaccine (V710): Results of two Phase I studies by Harro, Clayton D, Betts, Robert F, Hartzel, Jonathan S, Onorato, Matthew T, Lipka, Joy, Smugar, Steven S, Kartsonis, Nicholas A

“…Highlights ► V710 is a S. aureus vaccine containing the highly conserved IsdB surface protein. ► V710 was immunogenic in healthy subjects in a liquid,…”
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Pharmacokinetics, Safety, and Tolerability of Caspofungin in Children and Adolescents by WALSH, Thomas J, ADAMSON, Peter C, MILLER, Alisha, BRADSHAW, Susan K, LI, Susan X, SABLE, Carole A, KARTSONIS, Nicholas A, SEIBEL, Nita L, FLYNN, Patricia M, NEELY, Michael N, SCHWARTZ, Cindy, SHAD, Aziza, KAPLAN, Sheldon L, RODEN, Maureen M, STONE, Julie A

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Pharmacokinetics and Safety of Caspofungin in Older Infants and Toddlers by NEELY, Michael, JAFRI, Hasan S, STONE, Julie A, KARTSONIS, Nicholas A, SEIBEL, Nita, KNAPP, Katherine, ADAMSON, Peter C, BRADSHAW, Susan K, STROHMAIER, Kim M, PENG SUN, SHENG BI, FALLON DOCKENDORF, Marissa

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A randomized double-blind study of caspofungin versus fluconazole for the treatment of esophageal candidiasis by Villanueva, Alvaro, Gotuzzo, Eduardo, Arathoon, Eduardo G, Noriega, L Miguel, Kartsonis, Nicholas A, Lupinacci, Robert J, Smietana, Juanita M, DiNubile, Mark J, Sable, Carole A

“…Candida esophagitis remains an important cause of morbidity in patients with advanced human immunodeficiency virus (HIV) infection. Fluconazole is widely…”
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Caspofungin Use in Patients with Invasive Candidiasis Caused by Common Non-albicans Candida Species: Review of the Caspofungin Database by COLOMBO, Arnaldo L, NGAI, Angela L, BOURQUE, Michael, BRADSHAW, Susan K, STROHMAIER, Kim M, TAYLOR, Arlene F, LUPINACCI, Robert J, KARTSONIS, Nicholas A

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Population Pharmacokinetics and Pharmacodynamics of Caspofungin in Pediatric Patients by LI, Chi-Chung, PENG SUN, YINGWEN DONG, SHENG BI, DESAI, Rajesh, FALLON DOCKENDORF, Marissa, KARTSONIS, Nicholas A, NGAI, Angela L, BRADSHAW, Susan, STONE, Julie A

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RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections by Motsch, Johann, Murta de Oliveira, Cláudia, Stus, Viktor, Köksal, Iftihar, Lyulko, Olexiy, Boucher, Helen W, Kaye, Keith S, File, Thomas M, Brown, Michelle L, Khan, Ireen, Du, Jiejun, Joeng, Hee-Koung, Tipping, Robert W, Aggrey, Angela, Young, Katherine, Kartsonis, Nicholas A, Butterton, Joan R, Paschke, Amanda

“…Abstract Background The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem-nonsusceptible gram-negative pathogens. We evaluated…”
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Phase IIa Study of the Immunogenicity and Safety of the Novel Staphylococcus aureus Vaccine V710 in Adults with End-Stage Renal Disease Receiving Hemodialysis by Moustafa, Moustafa, Aronoff, George R, Chandran, Chandra, Hartzel, Jonathan S, Smugar, Steven S, Galphin, Claude M, Mailloux, Lionel U, Brown, Elizabeth, Dinubile, Mark J, Kartsonis, Nicholas A, Guris, Dalya

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study) by Titov, Ivan, Wunderink, Richard G, Roquilly, Antoine, Rodríguez Gonzalez, Daniel, David-Wang, Aileen, Boucher, Helen W, Kaye, Keith S, Losada, Maria C, Du, Jiejun, Tipping, Robert, Rizk, Matthew L, Patel, Munjal, Brown, Michelle L, Young, Katherine, Kartsonis, Nicholas A, Butterton, Joan R, Paschke, Amanda, Chen, Luke F

“…Abstract Background Imipenem combined with the β-lactamase inhibitor relebactam has broad antibacterial activity, including against carbapenem-resistant…”
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Phase 2, Dose-Ranging Study of Relebactam with Imipenem-Cilastatin in Subjects with Complicated Intra-abdominal Infection by Lucasti, Christopher, Vasile, Liviu, Sandesc, Dorel, Venskutonis, Donatas, McLeroth, Patrick, Lala, Mallika, Rizk, Matthew L, Brown, Michelle L, Losada, Maria C, Pedley, Alison, Kartsonis, Nicholas A, Paschke, Amanda

“…Relebactam (REL [MK-7655]) is a novel class A/C β-lactamase inhibitor intended for use with imipenem for the treatment of Gram-negative bacterial infections…”
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Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections by Sims, Matthew, Mariyanovski, Valeri, McLeroth, Patrick, Akers, Wayne, Lee, Yu-Chieh, Brown, Michelle L, Du, Jiejun, Pedley, Alison, Kartsonis, Nicholas A, Paschke, Amanda

“…The β-lactamase inhibitor relebactam can restore imipenem activity against imipenem non-susceptible pathogens. To explore relebactam's safety, tolerability and…”
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Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation by Marty, Francisco M, Ljungman, Per, Chemaly, Roy F, Maertens, Johan, Dadwal, Sanjeet S, Duarte, Rafael F, Haider, Shariq, Ullmann, Andrew J, Katayama, Yuta, Brown, Janice, Mullane, Kathleen M, Boeckh, Michael, Blumberg, Emily A, Einsele, Hermann, Snydman, David R, Kanda, Yoshinobu, DiNubile, Mark J, Teal, Valerie L, Wan, Hong, Murata, Yoshihiko, Kartsonis, Nicholas A, Leavitt, Randi Y, Badshah, Cyrus

“…CMV infection is a common complication in patients undergoing hematopoietic-cell transplantation. The incidence of CMV infection was 23 percentage points lower…”
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Pharmacokinetics, efficacy, and safety of caspofungin in Japanese pediatric patients with invasive candidiasis and invasive aspergillosis by Mori, Masaaki, Imaizumi, Masue, Ishiwada, Naruhiko, Kaneko, Takashi, Goto, Hiroaki, Kato, Koji, Hara, Junichi, Kosaka, Yoshiyuki, Koike, Kazutoshi, Kawamoto, Hiroshi, Maeda, Naoko, Yoshinari, Tomoko, Kishino, Hiroyuki, Takahashi, Kenichi, Kawahara, Shizuko, Kartsonis, Nicholas A, Komada, Yoshihiro

“…Abstract The antifungal agents approved in Japan for pediatric use are limited and many unapproved drugs are actually used without clear instruction for…”
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Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery: A Randomized Trial by Fowler, Vance G, Allen, Keith B, Moreira, Edson D, Moustafa, Moustafa, Isgro, Frank, Boucher, Helen W, Corey, G. Ralph, Carmeli, Yehuda, Betts, Robert, Hartzel, Jonathan S, Chan, Ivan S. F, McNeely, Tessie B, Kartsonis, Nicholas A, Guris, Dalya, Onorato, Matthew T, Smugar, Steven S, DiNubile, Mark J, Sobanjo-ter Meulen, Ajoke

“…IMPORTANCE Infections due to Staphylococcus aureus are serious complications of cardiothoracic surgery. A novel vaccine candidate (V710) containing the highly…”
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