Search Results - "KARP, Seth J"

Variability in Organ Procurement Organization Performance by Individual Hospital in the United States by Johnson, Wali, Kraft, Kathryn, Chotai, Pranit, Lynch, Raymond, Dittus, Robert S, Goldberg, David, Ye, Fei, Doby, Brianna, Schaubel, Douglas E, Shah, Malay B, Karp, Seth J

“…Availability of organs inadequately addresses the need of patients waiting for a transplant. To estimate the true number of donor patients in the United States…”
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Noninvasive Assessment of Liver Fibrosis: Current and Future Clinical and Molecular Perspectives by Masuzaki, Ryota, Kanda, Tatsuo, Sasaki, Reina, Matsumoto, Naoki, Ogawa, Masahiro, Matsuoka, Shunichi, Karp, Seth J, Moriyama, Mitsuhiko

“…Liver fibrosis is one of the risk factors for hepatocellular carcinoma (HCC) development. The staging of liver fibrosis can be evaluated only via a liver…”
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Suppressors of Cytokine Signaling and Hepatocellular Carcinoma by Masuzaki, Ryota, Kanda, Tatsuo, Sasaki, Reina, Matsumoto, Naoki, Nirei, Kazushige, Ogawa, Masahiro, Karp, Seth J, Moriyama, Mitsuhiko, Kogure, Hirofumi

“…Cytokines are secreted soluble glycoproteins that regulate cellular growth, proliferation, and differentiation. Suppressors of cytokine signaling (SOCS)…”
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Public attitudes toward contemporary issues in liver allocation by O'Dell, Heather W., McMichael, Benjamin J., Lee, Suzie, Karp, Jay L., VanHorn, R. Lawrence, Karp, Seth J.

“…Allocation of scarce livers for transplantation seeks to balance competing ethical principles of autonomy, utility, and justice. Given the history and ongoing…”
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Cytometry‐based single‐cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF‐α‐induced apoptosis in vivo by Simmons, Alan J, Banerjee, Amrita, McKinley, Eliot T, Scurrah, Cherie' R, Herring, Charles A, Gewin, Leslie S, Masuzaki, Ryota, Karp, Seth J, Franklin, Jeffrey L, Gerdes, Michael J, Irish, Jonathan M, Coffey, Robert J, Lau, Ken S

“…Understanding heterogeneous cellular behaviors in a complex tissue requires the evaluation of signaling networks at single‐cell resolution. However, probing…”
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BMP4 is a novel paracrine inhibitor of liver regeneration by Do, Nhue, Zhao, Rong, Ray, Kevin, Ho, Karen, Dib, Martin, Ren, Xianghui, Kuzontkoski, Paula, Terwilliger, Ernest, Karp, Seth J

“…Transforming growth factor (TGF)-β family members exert strong effects on restoration of liver mass after injury. Bone morphogenetic proteins (BMPs) are…”
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Transcriptional ontogeny of the developing liver by Lee, Janice S, Ward, William O, Knapp, Geremy, Ren, Hongzu, Vallanat, Beena, Abbott, Barbara, Ho, Karen, Karp, Seth J, Corton, J Christopher

“…During embryogenesis the liver is derived from endodermal cells lining the digestive tract. These endodermal progenitor cells contribute to forming the…”
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A Role for Extracellular Vesicles in Liver Fibrosis by Karp, Seth J

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CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy by Schmelzle, Moritz, Duhme, Constanze, Junger, Wolfgang, Salhanick, Steven D, Chen, Yu, Wu, Yan, Toxavidis, Vasilis, Csizmadia, Eva, Han, Lihui, Bian, Shu, Fürst, Günter, Nowak, Martina, Karp, Seth J, Knoefel, Wolfram T, Esch, Jan Schulte Am, Robson, Simon C

“…To study molecular mechanisms involved in hematopoietic stem cell (HSC) mobilization after liver resection and determine impacts on liver regeneration…”
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Restoration of Liver Mass after Injury Requires Proliferative and Not Embryonic Transcriptional Patterns by Otu, Hasan H., Naxerova, Kamila, Ho, Karen, Can, Handan, Nesbitt, Nicole, Libermann, Towia A., Karp, Seth J.

“…Normal adult liver is uniquely capable of renewal and repair after injury. Whether this response represents simple hyperplasia of various liver elements or…”
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Netrin-1: Needed Help for Throughput in the ER in Patients With Liver Disease by Karp, Seth J., MD

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Effect of Donor Transaminase Levels on Graft Survival Following Liver Transplant: An Analysis of the Organ Procurement and Transplantation Network Database by Ziogas, Ioannis A, Martins, Paulo N, Alexopoulos, Sophoclis P, Matsuoka, Lea K, Rauf, Muhammad A, Geevarghese, Sunil K, Gorden, Lee D, Karp, Seth J, Perkins, James D, Montenovo, Martin I

“…Despite data showing equivalent outcomes between grafts from marginal versus standard criteria deceased liver donors, elevated donor transaminases constitute a…”
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The Importance of Outcome Metrics in Allocation Policy by Karp, Seth J

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New Serum Markers of Hepatocellular Carcinoma by Masuzaki, Ryota, Karp, Seth J, Omata, Masao

“…Hepatocellular carcinoma (HCC), one of the most common cancers worldwide, usually develops in a liver already suffering from chronic damages, often cirrhosis…”
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Cytometry‐based single‐cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF‐α‐induced apoptosis in vivo by Simmons, Alan J, Banerjee, Amrita, McKinley, Eliot T, Scurrah, Cherie’ R, Herring, Charles A, Gewin, Leslie S, Masuzaki, Ryota, Karp, Seth J, Franklin, Jeffrey L, Gerdes, Michael J, Irish, Jonathan M, Coffey, Robert J, Lau, Ken S

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Effects of the March 2021 Allocation Policy Change on Key Deceased-donor Kidney Transplant Metrics by Cutrone, Alissa M, Rega, Scott A, Feurer, Irene D, Karp, Seth J

“…A major change to deceased-donor kidney allocation in the United States, Kidney Allocation System 250 (KAS250), was implemented on March 15, 2021. Evaluating…”
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Assessing LSAM's ability to account for changes in organ donation and transplant center behavior by Blandon, Catherine, Karp, Seth J, Shah, Malay, Lynch, Raymond J, Goldberg, David S

“…The Liver Simulated Allocation Model (LSAM) is used to evaluate proposed organ allocation policies. Although LSAM has been shown to predict the directionality…”
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Scar formation and lack of regeneration in adult and neonatal liver after stromal injury by Masuzaki, Ryota, Zhao, Sophia R., Csizmadia, Eva, Yannas, Ioannis, Karp, Seth J.

“…Known as a uniquely regenerative tissue, the liver shows a remarkable capacity to heal without scarring after many types of acute injury. In contrast, during…”
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Integrin β1 Establishes Liver Microstructure and Modulates Transforming Growth Factor β during Liver Development and Regeneration by Masuzaki, Ryota, Ray, Kevin C., Roland, Joseph, Zent, Roy, Lee, Youngmin A., Karp, Seth J.

“…A unique and complex microstructure underlies the diverse functions of the liver. Breakdown of this organization, as occurs in fibrosis and cirrhosis, impairs…”
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State‐Based Liver Distribution: Broad Sharing With Less Harm to Vulnerable and Underserved Communities Compared With Concentric Circles by Lynch, Raymond J., Ye, Fei, Sheng, Quanhu, Zhao, Zhiguo, Karp, Seth J.

“…Allocation of livers for transplantation faces regulatory pressure to move toward broader sharing. A current proposal supported by the United Network for Organ…”
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