Search Results - "KARP, Christopher L"

Unstressing intemperate models: how cold stress undermines mouse modeling by Karp, Christopher L

“…Mus musculus enjoys pride of place at the center of contemporary biomedical research. Despite being the current model system of choice for in vivo mechanistic…”
Get full text

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection by Shen, Yue, Torchia, Maria Letizia Giardino, Lawson, Gregory W., Karp, Christopher L., Ashwell, Jonathan D., Mazmanian, Sarkis K.

“…Commensal bacteria impact host health and immunity through various mechanisms, including the production of immunomodulatory molecules. Bacteroides fragilis…”
Get full text

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection by Wilson, Elizabeth B., Yamada, Douglas H., Elsaesser, Heidi, Herskovitz, Jonathan, Deng, Jane, Cheng, Genhong, Aronow, Bruce J., Karp, Christopher L., Brooks, David G.

“…Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease…”
Get full text

Microbiota maintain colonic homeostasis by activating TLR2/MyD88/PI3K signaling in IL-10-producing regulatory B cells by Mishima, Yoshiyuki, Oka, Akihiko, Liu, Bo, Herzog, Jeremy W, Eun, Chang Soo, Fan, Ting-Jia, Bulik-Sullivan, Emily, Carroll, Ian M, Hansen, Jonathan J, Chen, Liang, Wilson, Justin E, Fisher, Nancy C, Ting, Jenny Py, Nochi, Tomonori, Wahl, Angela, Garcia, J Victor, Karp, Christopher L, Sartor, R Balfour

“…Resident microbiota activate regulatory cells that modulate intestinal inflammation and promote and maintain intestinal homeostasis. IL-10 is a key mediator of…”
Get full text

The TLR4 antagonist Eritoran protects mice from lethal influenza infection by Shirey, Kari Ann, Lai, Wendy, Scott, Alison J., Lipsky, Michael, Mistry, Pragnesh, Pletneva, Lioubov M., Karp, Christopher L., McAlees, Jaclyn, Gioannini, Theresa L., Weiss, Jerrold, Chen, Wilbur H., Ernst, Robert K., Rossignol, Daniel P., Gusovsky, Fabian, Blanco, Jorge C. G., Vogel, Stefanie N.

“…TLR4 stimulation is known to contribute to acute lung injury after administration of inactivated influenza virus; here, the synthetic TLR4 antagonist Eritoran…”
Get full text

IL‐17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice by Harley, Isaac T.W., Stankiewicz, Traci E., Giles, Daniel A., Softic, Samir, Flick, Leah M., Cappelletti, Monica, Sheridan, Rachel, Xanthakos, Stavra A., Steinbrecher, Kris A., Sartor, R. Balfour, Kohli, Rohit, Karp, Christopher L., Divanovic, Senad

“…Inflammation plays a central pathogenic role in the pernicious metabolic and end‐organ sequelae of obesity. Among these sequelae, nonalcoholic fatty liver…”
Get full text

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein by Karp, Christopher L, Trompette, Aurelien, Divanovic, Senad, Visintin, Alberto, Blanchard, Carine, Hegde, Rashmi S, Madan, Rajat, Thorne, Peter S, Wills-Karp, Marsha, Gioannini, Theresa L, Weiss, Jerry P

“…Aeroallergy results from maladaptive immune responses to ubiquitous, otherwise innocuous environmental proteins. Although the proteins targeted by aeroallergic…”
Get full text

Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology by Nebert, Daniel W., Karp, Christopher L.

Get full text

Circulatory Antigen Processing by Mucosal Dendritic Cells Controls CD8+ T Cell Activation by Chang, Sun-Young, Song, Joo-Hye, Guleng, Bayasi, Cotoner, Carmen Alonso, Arihiro, Seiji, Zhao, Yun, Chiang, Hao-Sen, O’Keeffe, Michael, Liao, Gongxian, Karp, Christopher L., Kweon, Mi-Na, Sharpe, Arlene H., Bhan, Atul, Terhorst, Cox, Reinecker, Hans-Christian

“…Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics…”
Get full text

Guilt by intimate association: What makes an allergen an allergen? by Karp, Christopher L., MD

“…Why specific, ubiquitous, otherwise innocuous environmental proteins tend to provoke maladaptive, TH 2-polarized immune responses in susceptible hosts is a…”
Get full text

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation by Madan, Rajat, Demircik, Filiz, Surianarayanan, Sangeetha, Allen, Jessica L, Divanovic, Senad, Trompette, Aurelien, Yogev, Nir, Gu, Yuanyuan, Khodoun, Marat, Hildeman, David, Boespflug, Nicholas, Fogolin, Mariela B, Grobe, Lothar, Greweling, Marina, Finkelman, Fred D, Cardin, Rhonda, Mohrs, Markus, Muller, Werner, Waisman, Ari, Roers, Axel, Karp, Christopher L

“…IL-10 plays a central role in restraining the vigor of inflammatory responses, but the critical cellular sources of this counter-regulatory cytokine remain…”
Get full text

ATF3 is a novel regulator of mouse neutrophil migration by Boespflug, Nicholas D., Kumar, Sachin, McAlees, Jaclyn W., Phelan, James D., Grimes, H. Leighton, Hoebe, Kasper, Hai, Tsonwin, Filippi, Marie-Dominique, Karp, Christopher L.

“…Expression of the activating transcription factor 3 (ATF3) gene is induced by Toll-like receptor (TLR) signaling. In turn, ATF3 protein inhibits the expression…”
Get full text

Emergence of Distinct Multiarmed Immunoregulatory Antigen-Presenting Cells during Persistent Viral Infection by Wilson, Elizabeth B., Kidani, Yoko, Elsaesser, Heidi, Barnard, Jennifer, Raff, Laura, Karp, Christopher L., Bensinger, Steven, Brooks, David G.

“…During persistent viral infection, adaptive immune responses are suppressed by immunoregulatory factors, contributing to viral persistence. Although this…”
Get full text

Opposing Biological Functions of Tryptophan Catabolizing Enzymes During Intracellular Infection by Divanovic, Senad, Sawtell, Nancy M., Trompette, Aurelien, Warning, Jamie I., Dias, Alexandra, Cooper, Andrea M., Yap, George S., Arditi, Moshe, Shimada, Kenichi, DuHadaway, James B., Prendergast, George C., Basaraba, Randall J., Mellor, Andrew L., Munn, David H., Aliberti, Julio, Karp, Christopher L.

“…Recent studies have underscored physiological and pathophysiological roles for the tryptophan-degrading enzyme indolamine 2,3-dioxygenase (IDO) in immune…”
Get full text

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice by Giles, Daniel A, Ramkhelawon, Bhama, Donelan, Elizabeth M, Stankiewicz, Traci E, Hutchison, Susan B, Mukherjee, Rajib, Cappelletti, Monica, Karns, Rebekah, Karp, Christopher L, Moore, Kathryn J, Divanovic, Senad

“…Abstract Objectives Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of…”
Get full text

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105 by Karp, Christopher L, Divanovic, Senad, Trompette, Aurelien, Atabani, Sowsan F, Madan, Rajat, Golenbock, Douglas T, Visintin, Alberto, Finberg, Robert W, Tarakhovsky, Alexander, Vogel, Stefanie N, Belkaid, Yasmine, Kurt-Jones, Evelyn A

“…Activation of Toll-like receptor (TLR) signaling by microbial signatures is critical to the induction of immune responses. Such responses demand tight…”
Get full text

Obesity and the gut microbiome: Striving for causality by Harley, Isaac T.W, Karp, Christopher L

“…Abstract The gut microbiome has been proposed to play a causal role in obesity. Here, we review the historical context for this hypothesis, highlight recent…”
Get full text

SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia by Korfhagen, Thomas R, Kitzmiller, Joseph, Chen, Gang, Sridharan, Anusha, Haitchi, Hans-Michael, Hegde, Rashmi S, Divanovic, Senad, Karp, Christopher L, Whitsett, Jeffrey A

“…Airway mucus plays a critical role in clearing inhaled toxins, particles, and pathogens. Diverse toxic, inflammatory, and infectious insults induce airway…”
Get full text

IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis by Kobayashi, Taku, Matsuoka, Katsuyoshi, Sheikh, Shehzad Z, Russo, Steven M, Mishima, Yoshiyuki, Collins, Colm, deZoeten, Edwin F, Karp, Christopher L, Ting, Jenny P Y, Sartor, R Balfour, Plevy, Scott E

“…To prevent excessive inflammatory responses to commensal microbes, intestinal macrophages, unlike their systemic counterparts, do not produce inflammatory…”
Get full text

Interleukin-13: Central Mediator of Allergic Asthma by Wills-Karp, Marsha, Luyimbazi, Jackie, Xu, Xueying, Schofield, Brian, Neben, Tamlyn Y., Karp, Christopher L., Donaldson, Debra D.

“…The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result…”
Get full text