Search Results - "KARLSEN, A. E"

Flecainide overdose-induced Brugada electrocardiogram pattern by Nam, M C Y, Karlsen, E-A, Woo, E, Dayananda, N, Greaves, K, Stanton, T

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Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia? by Hansen, A. M. K., Bödvarsdottir, T. B., Nordestgaard, D. N. E., Heller, R. S., Gotfredsen, C. F., Maedler, K., Fels, J. J., Holst, J. J., Karlsen, A. E.

“…Aims/hypothesis The hormone glucagon-like peptide 1 (GLP-1) is released in response to a meal from the intestinal L-cells, where it is processed from…”
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Effects of 12 weeks’ treatment with a proton pump inhibitor on insulin secretion, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind prospective placebo-controlled study by Hove, K. D., Brøns, C., Færch, K., Lund, S. S., Petersen, J. S., Karlsen, A. E., Rossing, P., Rehfeld, J. F., Vaag, A.

“…Aims/hypothesis Recent studies suggest that proton pump inhibitor treatment may increase insulin secretion and improve glucose metabolism in type 2 diabetes…”
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Treatment with a proton pump inhibitor improves glycaemic control in Psammomys obesus, a model of type 2 diabetes by Bödvarsdóttir, T. B, Hove, K. D, Gotfredsen, C. F, Pridal, L, Vaag, A, Karlsen, A. E, Petersen, J. S

“…Aims/hypothesis Gastrin has been implicated in islet growth/neogenesis, and proton pump inhibitors (PPIs) have been shown to increase endogenous gastrin levels…”
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Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes by LORTZ, S, TIEDGE, M, NACHTWEY, T, KARLSEN, A. E, NERUP, J, LENZEN, S

“…Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. S Lortz , M Tiedge , T Nachtwey…”
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The harmony of the spheres : inducible nitric oxide synthase and related genes in pancreatic beta cells by EIZIRIK, D. L, FLODSTRÖM, M, KARLSEN, A. E, WELSH, N

“…The radical nitric oxide (NO) is a possible mediator of pancreatic beta-cell damage in insulin-dependent diabetes mellitus (IDDM). NO is produced by the enzyme…”
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Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection by Rønn, S. G, Börjesson, A, Bruun, C, Heding, P. E, Frobøse, H, Mandrup-Poulsen, T, Karlsen, A. E, Rasschaert, J, Sandler, S, Billestrup, N

“…Aims/hypothesis The pro-inflammatory cytokines IL-1 and IFNγ are critical molecules in immune-mediated beta cell destruction leading to type 1 diabetes…”
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A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM by GRUBIN, C. E, DANIELS, T, TOIVOLA, B, LANDIN-OLSSON, M, HAGOPIAN, W. A, LI, L, KARLSEN, A. E, BOEL, E, MICHELSEN, B, LERNMARK, Å

“…Insulin-dependent diabetes mellitus (IDDM) is associated with autoreactivity against GAD but the diagnostic sensitivity (positivity in disease) and specificity…”
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Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity by GYLVIN, T, NOLSØE, R, NERUP, J, POCIOT, F, HANSEN, T, NIELSEN, E. M. D, BERGHOLDT, R, KARLSEN, A. E, BILLESTRUP, N, BORCH-JOHNSEN, K, PEDERSEN, O, MANDRUP-POULSEN, T

“…Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine…”
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Beta-cell maturation leads to in vitro sensitivity to cytotoxins by NIELSEN, K, KARLSEN, A. E, DECKERT, M, MADSEN, O. D, SERUP, P, MANDRUP-POULSEN, T, NERUP, J

“…Beta-cell maturation leads to in vitro sensitivity to cytotoxins. K Nielsen , A E Karlsen , M Deckert , O D Madsen , P Serup , T Mandrup-Poulsen and J Nerup…”
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Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells by MORGAN, D. G, KULKARNI, R. N, HURLEY, J. D, WANG, Z. L, WANG, R. M, GHATEI, M. A, KARLSEN, A. E, BLOOM, S. R, SMITH, D. M

“…Neuropeptide Y (NPY) has been shown to inhibit insulin secretion from the islets of Langerhans. We show that insulin secretion in the insulinoma cell line RIN…”
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Onset of type 1 diabetes: a dynamical instability by FREIESLEBEN DE BLASIO, B, BAK, P, POCIOT, F, KARLSEN, A. E, NERUP, J

“…Onset of type 1 diabetes: a dynamical instability. B Freiesleben De Blasio , P Bak , F Pociot , A E Karlsen and J Nerup Niels Bohr Institute, Copenhagen,…”
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Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways by KARLSEN, A. E, HEDING, P. E, MANDRUP-POULSEN, T, BILLESTRUP, N, FROBØSE, H, RØNN, S. G, KRUHØFFER, M, ØRNTOFT, T. F, DARVILLE, M, EIZIRIK, D. L, POCIOT, F, NERUP, J

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Cloning and Primary Structure of a Human Islet Isoform of Glutamic Acid Decarboxylase from Chromosome 10 by Karlsen, Allan E., Hagopian, William A., Grubin, Catherine E., Dube, Syamalima, Disteche, Christine M., Adler, David A., Barmeier, Heike, Mathewes, Shannon, Grant, Francis J., Foster, Don, Lernmark, Ake

“…Glutamic acid decarboxylase (GAD; glutamate decarboxylase, L-glutamate 1-carboxy-lyase, EC 4.1.1.15), which catalyzes formation of γ-aminobutyric acid from…”
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Proteome Analysis of Interleukin-1β–Induced Changes in Protein Expression in Rat Islets of Langerhans by MOSE LARSEN, P, FEY, S. J, KARLSEN, A. E, NERUP, J, LARSEN, M. R, NAWROCKI, A, ANDERSEN, H. U, KÄHLER, H, HEILMANN, C, VOSS, M. C, ROEPSTORFF, P, POCIOT, F

“…Proteome Analysis of Interleukin-1β–Induced Changes in Protein Expression in Rat Islets of Langerhans P. Mose Larsen 1 , S.J. Fey 1 , M.R. Larsen 2 , A…”
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Gene expression profiles during beta cell maturation and after IL-1β exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1β sensitivity by NIELSEN, K, KRUHØFFER, M, ØRNTOFT, T, SPARRE, T, WANG, H, WOLLHEIM, C, JØRGENSEN, M. C, NERUP, J, KARLSEN, A. E

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On the pathogenesis of IDDM by Nerup, J, Mandrup-Poulsen, T, Helqvist, S, Andersen, H U, Pociot, F, Reimers, J I, Cuartero, B G, Karlsen, A E, Bjerre, U, Lorenzen, T

“…A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion…”
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Changes in expression of IL-1β influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats by SPARRE, T, CHRISTENSEN, U. Bjerre, GOTFREDSEN, C. F, LARSEN, P. Mose, FEY, S. J, HJERNØ, K, ROEPSTORFF, P, POCIOT, F, KARLSEN, A. E, NERUP, J

“…Type 1 diabetes mellitus is a multifactorial autoimmune disease characterised by selective destruction of beta cells in the islets of Langerhans. We have…”
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The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines by Nikulina, M.A., Sandhu, N., Shamim, Z., Andersen, N.A., Oberson, A., Dupraz, P., Thorens, B., Karlsen, A.E., Bonny, C., Mandrup-Poulsen, T.

“…The stress-activated protein kinase c-Jun NH 2-terminal kinase (JNK) is a central signal for interleukin-1β (IL-1β)-induced apoptosis in insulin-producing…”
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Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type by HAGOPIAN, W. A, KARLSEN, A. E, GOTTSÄTER, A, LANDIN-OLSSON, M, GRUBIN, C. E, SUNDKVIST, G, PETERSEN, J. S, BOEL, E, DYRBERG, T, LERNMARK, Å

“…At and before onset, most insulin-dependent diabetics (IDDM) have islet GAD65 autoantibodies (GAD65Ab). Since IDDM also occurs in older patients where…”
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