Search Results - "KARKKAINEN, MARIKA J."

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos by Haiko, Paula, Makinen, Taija, Keskitalo, Salla, Taipale, Jussi, Karkkainen, Marika J., Baldwin, Megan E., Stacker, Steven A., Achen, Marc G., Alitalo, Kari

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins by Alitalo, Kari, Karkkainen, Marika J, Haiko, Paula, Sainio, Kirsi, Partanen, Juha, Taipale, Jussi, Petrova, Tatiana V, Jeltsch, Michael, Jackson, David G, Talikka, Marja, Rauvala, Heikki, Betsholtz, Christer

“…Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause…”
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Abnormal lymphatic vessel development in neuropilin 2 mutant mice by Yuan, Li, Moyon, Delphine, Pardanaud, Luc, Bréant, Christiane, Karkkainen, Marika J, Alitalo, Kari, Eichmann, Anne

“…Neuropilin 2 is a receptor for class III semaphorins and for certain members of the vascular endothelial growth factor family. Targeted inactivation of the…”
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Lymphatic endothelium: a new frontier of metastasis research by Karkkainen, Marika J, Mäkinen, Taija, Alitalo, Kari

“…The vascular endothelium is a dynamic tissue with many active functions. Until recently, endothelial cell (EC) biology studies have used cultured ECs from…”
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Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites by Dixelius, Johan, Mäkinen, Taija, Wirzenius, Maria, Karkkainen, Marika J., Wernstedt, Christer, Alitalo, Kari, Claesson-Welsh, Lena

“…Vascular endothelial growth factors (VEGFs) regulate the development and growth of the blood and lymphatic vascular systems. Of the three VEGF receptors…”
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A Model for Gene Therapy of Human Hereditary Lymphedema by Karkkainen, Marika J., Saaristo, Anne, Jussila, Lotta, Karila, Kaisa A., Lawrence, Elizabeth C., Pajusola, Katri, Bueler, Hansruedi, Eichmann, Anne, Kauppinen, Risto, Kettunen, Mikko I., Ylä-Herttuala, Seppo, Finegold, David N., Ferrell, Robert E., Alitalo, Kari

“…Primary human lymphedema (Milroy's disease), characterized by a chronic and disfiguring swelling of the extremities, is associated with heterozygous…”
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VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain by Thomas, Jean-Léon, Le Bras, Barbara, Barallobre, Maria-José, Homman-Ludiye, Jihane, Ny, Annelii, Wyns, Sabine, Tammela, Tuomas, Haiko, Paula, Karkkainen, Marika J, Yuan, Li, Muriel, Marie-Paule, Chatzopoulou, Elli, Bréant, Christiane, Zalc, Bernard, Carmeliet, Peter, Alitalo, Kari, Eichmann, Anne

“…Vascular endothelial growth factor C (VEGF-C) was first identified as a regulator of the vascular system, where it is required for the development of lymphatic…”
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Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema by Karlsen, Tine V., Karkkainen, Marika J., Alitalo, Kari, Wiig, Helge

“…To investigate the phenotypic consequences of a deranged lymphangiogenesis in relation to tissue fluid accumulation and the possible role of inflammation in…”
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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation by Saharinen, Pipsa, Tammela, Tuomas, Karkkainen, Marika J, Alitalo, Kari

“…The lymphatic vascular system is important for immune surveillance, tissue fluid homeostasis and fat absorption, and is involved in many pathological…”
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Molecular regulation of lymphangiogenesis and targets for tissue oedema by Karkkainen, Marika J, Jussila, Lotta, Alitalo, Kari, Ferrell, Robert E, Finegold, David N

“…New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth…”
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Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth by KARPANEN, Terhi, EGEBLAD, Mikala, KARKKAINEN, Marika J, KUBO, Hajime, YLÄ-HERTTUALA, Seppo, JÄÄTTELÄ, Marja, ALITALO, Kari

“…Many solid tumors produce vascular endothelial growth factor C (VEGF-C), and its receptor, VEGFR-3, is expressed in tumor blood vessels. To study the role of…”
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Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis by Karkkainen, M J, Petrova, T V

“…VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth…”
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Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis by HE, Yulong, RAJANTIE, Iiro, ILMONEN, Maritta, MAKINEN, Taija, KARKKAINEN, Marika J, HAIKO, Paula, SALVER, Petri, ALITALO, Kari

“…Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone…”
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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema by Ferrell, Robert E, Karkkainen, Marika J, Lawrence, Elizabeth C, Kimak, Mark A, Levinson, Kara L, McTigue, Michele A, Alitalo, Kari, Finegold, David N

“…Primary lymphoedema is a rare, autosomal dominant disorder that leads to a disabling and disfiguring swelling of the extremities and, when untreated, tends to…”
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Therapeutic lymphangiogenesis with human recombinant VEGF‐C by Szuba, Andrzej, Skobe, Mihaela, Karkkainen, Marika J., Shin, William S., Beynet, David P., Rockson, Ned B., Dakhil, Noma, Spilman, Stan, Goris, Michael L., Strauss, H. William, Quertermous, Thomas, Alitalo, Kari, Rockson, Stanley G.

“…ABSTRACT Chronic regional impairments of the lymphatic circulation often lead to striking architectural abnormalities in the lymphedematous tissues. Lymphedema…”
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Lymphangiogenic gene therapy with minimal blood vascular side effects by Saaristo, Anne, Veikkola, Tanja, Tammela, Tuomas, Enholm, Berndt, Karkkainen, Marika J, Pajusola, Katri, Bueler, Hansruedi, Ylä-Herttuala, Seppo, Alitalo, Kari

“…Recent work from many laboratories has demonstrated that the vascular endothelial growth factor-C/VEGF-D/VEGFR-3 signaling pathway is crucial for…”
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Adenoviral VEGF‐C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes by SAARISTO, ANNE, VEIKKOLA, TANJA, ENHOLM, BERNDT, HYTÖNEN, MAIJA, AROLA, JOHANNA, PAJUSOLA, KATRI, TURUNEN, PAIVI, JELTSCH, MICHAEL, KARKKAINEN, MARIKA J., KERJASCHKI, DONTSCHO, BUELER, HANSRUEDI, YLA‐HERTTUALA, SEPPO, ALITALO, KARI

“…ABSTRACT Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are important regulators of blood and lymphatic vessel growth and vascular…”
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Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis by Karkkainen, Marika J, Alitalo, Kari

“…Vascular endothelial growth factor receptor-3 (VEGFR-3) mediates lymphatic endothelial cell (LEC) growth, migration, and survival by binding VEGF-C and VEGF-D…”
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The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man by Baldwin, Megan E., Catimel, Bruno, Nice, Edouard C., Roufail, Sally, Hall, Nathan E., Stenvers, Kaye L., Karkkainen, Marika J., Alitalo, Kari, Stacker, Steven A., Achen, Marc G.

“…Human vascular endothelial growth factor-D (VEGF-D) binds and activates VEGFR-2 and VEGFR-3, receptors expressed on vascular and lymphatic endothelial cells…”
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Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells by Ruohola, Johanna K., Valve, Eeva M., Karkkainen, Marika J., Joukov, Vladimir, Alitalo, Kari, Härkönen, Pirkko L.

“…Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and an important prognostic factor in breast cancer. Hypoxia is an important…”
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