Search Results - "KARHU, Ritva"

Preservation of nucleic acids and tissue morphology in paraffin-embedded clinical samples: comparison of five molecular fixatives by Staff, Synnöve, Kujala, Paula, Karhu, Ritva, Rökman, Annika, Ilvesaro, Joanna, Kares, Saara, Isola, Jorma

“…Formalin fixation preserves tissue morphology at the expense of macromolecule integrity. Freshly frozen samples are the golden standard for DNA and RNA…”
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A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7 by ALARMO, Emma-Leena, KUUKASJÄRVI, Tuula, KARHU, Ritva, KALLIONIEMI, Anne

“…Bone morphogenetic proteins (BMPs) regulate diverse cellular processes, such as proliferation, differentiation, and apoptosis. The BMPs have been studied in…”
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BMP7 influences proliferation, migration, and invasion of breast cancer cells by Alarmo, Emma-Leena, Pärssinen, Jenita, Ketolainen, Johanna M, Savinainen, Kimmo, Karhu, Ritva, Kallioniemi, Anne

“…Abstract Bone morphogenetic protein 7 (BMP7) is a signaling molecule originally identified based on its ability to form bone. It is essential during…”
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Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial by Norén‐Nyström, Ulrika, Andersen, Mette K., Barbany, Gisela, Dirse, Vaidas, Eilert‐Olsen, Martine, Engvall, Marie, Harila‐Saari, Arja, Heyman, Mats, Hovland, Randi, Häikiö, Satu, Jónsson, Jón J., Karhu, Ritva, Kjeldsen, Eigil, Norberg, Anna, Preiss, Birgitte S., Pulkkinen, Kati, Quist‐Paulsen, Petter, Räsänen, Hannele, Schmiegelow, Kjeld, Seitsonen, Anne, Sjögren, Helene, Tammur, Pille, Johansson, Bertil

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The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours by RAUTA, Jenita, ALARMO, Emma-Leena, KAURANIEMI, Päivikki, KARHU, Ritva, KUUKASJÄRVI, Tuula, KALLIONIEMI, Anne

“…The serine-threonine protein phosphatase PPM1D is likely to play an important role in tumorigenesis. Through inactivation of p38 MAPK, PPM1D acts as a negative…”
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Frequent amplification of 8q24, 11q, 17q, and 20q-specific genes in pancreatic cancer by Mahlamäki, Eija H., Bärlund, Maarit, Tanner, Minna, Gorunova, Ludmila, Höglund, Mattias, Karhu, Ritva, Kallioniemi, Anne

“…Genetic changes involved in the development and progression of pancreatic cancer are still partly unknown, despite the progress in recent years. In this study,…”
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Array-based gene expression, CGH and tissue data defines a 12q24 gain in neuroblastic tumors with prognostic implication by Wolf, Maija, Korja, Miikka, Karhu, Ritva, Edgren, Henrik, Kilpinen, Sami, Ojala, Kalle, Mousses, Spyro, Kallioniemi, Anne, Haapasalo, Hannu

“…Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a…”
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Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer by Alarmo, Emma-Leena, Rauta, Jenita, Kauraniemi, Päivikki, Karhu, Ritva, Kuukasjärvi, Tuula, Kallioniemi, Anne

“…Bone morphogenetic proteins (BMP) make up a family of extracellular signaling molecules that play a critical role in vertebrate development and both inhibit…”
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High-Resolution Analysis of Gene Copy Number Alterations in Human Prostate Cancer Using CGH on cDNA Microarrays: Impact of Copy Number on Gene Expression by Wolf, Maija, Mousses, Spyro, Hautaniemi, Sampsa, Karhu, Ritva, Huusko, Pia, Allinen, Minna, Elkahloun, Abdel, Monni, Outi, Chen, Yidong, Kallioniemi, Anne, Kallioniemi, Olli-P

“…Identification of target genes for genetic rearrangements in prostate cancer and the impact of copy number changes on gene expression are currently not well…”
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Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping by Kytölä, Soili, Rummukainen, Jaana, Nordgren, Ann, Karhu, Ritva, Farnebo, Filip, Isola, Jorma, Larsson, Catharina

“…Breast cancer cell lines have been widely used as models in functional and therapeutical studies, but their chromosomal alterations are not well known. We…”
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Genotypic Stability, Segregation and Selection in Heteroplasmic Human Cell Lines Containing np 3243 Mutant mtDNA by Lehtinen, Sanna K, Hance, Nicole, El Meziane, Abdellatif, Juhola, M. Katariina, Juhola, K. Martti I, Karhu, Ritva, Spelbrink, Johannes N, Holt, Ian J, Jacobs, Howard T

“…The mitochondrial genotype of heteroplasmic human cell lines containing the pathological np 3243 mtDNA mutation, plus or minus its suppressor at np 12300, has…”
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Genetic aberrations in hypodiploid breast cancer: Frequent loss of chromosome 4 and amplification of cyclin D1 oncogene by TANNER, M. M, KARHU, R. A, NUPPONEN, N. N, BORG, A, BALDETORP, B, PEJOVIC, T, FERNÖ, M, KILLANDER, D, ISOLA, J. J

“…The evolution of somatic genetic aberrations in breast cancer has remained poorly understood. The most common chromosomal abnormality is hyperdiploidy, which…”
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Pancreatic adenocarcinoma-Genetic portrait from chromosomes to microarrays by Karhu, Ritva, Mahlamäki, Eija, Kallioniemi, Anne

“…Pancreatic adenocarcinoma is the fifth leading cause of cancer death with a 5‐year survival rate of less than 5%. Although the role of a few known oncogenes…”
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Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification by KUUSELO, Riina, SAVINAINEN, Kimmo, AZORSA, David O, BASU, Gargi D, KARHU, Ritva, TUZMEN, Sukru, MOUSSES, Spyro, KALLIONIEMI, Anne

“…Pancreatic cancer is a highly aggressive disease characterized by poor prognosis and vast genetic instability. Recent microarray-based, genome-wide surveys…”
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Patterns of chromosomal imbalances defines subgroups of breast cancer with distinct clinical features and prognosis. A study of 305 tumors by comparative genomic hybridization by RENNSTAM, Karin, AHLSTEDT-SOINI, Minna, BALDETORP, Bo, BENDAHL, Pär-Ola, BORG, Ake, KARHU, Ritva, TANNER, Minna, TIRKKONEN, Mika, ISOLA, Jorma

“…Chromosomal copy number aberrations (CNAs) are common in breast cancer and involve genomic regions in a frequency and combination, suggesting distinct routes…”
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19q13 amplification is associated with high grade and stage in pancreatic cancer by Kuuselo, Riina, Simon, Ronald, Karhu, Ritva, Tennstedt, Pierre, Marx, Andreas H., Izbicki, Jakob R., Yekebas, Emre, Sauter, Guido, Kallioniemi, Anne

“…Pancreatic cancer is a devastating disease with an extremely poor prognosis, and thus, there is a great need for better diagnostic and therapeutic tools. The…”
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Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma by Nordfors, Kristiina, Haapasalo, Joonas, Afyounian, Ebrahim, Tuominen, Joonas, Annala, Matti, Häyrynen, Sergei, Karhu, Ritva, Helén, Pauli, Lohi, Olli, Nykter, Matti, Haapasalo, Hannu, Granberg, Kirsi J

“…Brain tumors typically arise sporadically and do not affect several family members simultaneously. In the present study, we describe clinical and genetic data…”
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Erratum: Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma by Nordfors, Kristiina, Haapasalo, Joonas, Afyounian, Ebrahim, Tuominen, Joonas, Annala, Matti, Häyrynen, Sergei, Karhu, Ritva, Helén, Pauli, Lohi, Olli, Nykter, Matti, Haapasalo, Hannu, Granberg, Kirsi J

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High-Resolution Analysis of Gene Copy Number Alterations in Human Prostate Cancer Using CGH on cDNA Microarrays: Impact of Copy Number on Gene Expression by Wolf, M, Mousses, S, Hautaniemi, S, Karhu, R, Huusko, P, Allinen, M, Abdel Elkahloun, Monni, O, Chen, Y, Kallioniemi, A, Kallioniemi, O-P

“…Identification of target genes for genetic rearrangements in prostate cancer and the impact of copy number changes on gene expression are currently not well…”
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Molecular cytogenetics of primary breast cancer by CGH by Tirkkonen, Mika, Tanner, Minna, Karhu, Ritva, Kallioniemi, Anne, Isola, Jorma, Kallioniemi, Olli-P.

“…Comparative genomic hybridization (CGH) reveals DNA sequence copy number changes that are shared among the different cell subpopulations present in a tumor and…”
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