Search Results - "KARDINAL, CHRISTIAN"

Tyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex by Tossidou, Irini, Teng, Beina, Worthmann, Kirstin, Müller-Deile, Janina, Jobst-Schwan, Tilman, Kardinal, Christian, Schroder, Patricia, Bolanos-Palmieri, Patricia, Haller, Hermann, Willerding, Jonas, Drost, Dana M, de Jonge, Laura, Reubold, Thomas, Eschenburg, Susanne, Johnson, Ruth I, Schiffer, Mario

“…CD2-associated protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is…”
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CD2AP/CIN85 Balance Determines Receptor Tyrosine Kinase Signaling Response in Podocytes by Tossidou, Irini, Kardinal, Christian, Peters, Imke, Kriz, Wilhelm, Shaw, Andrey, Dikic, Ivan, Tkachuk, Sergej, Dumler, Inna, Haller, Hermann, Schiffer, Mario

“…Defects in podocyte signaling are the basis of many inherited glomerular diseases leading to glomerulosclerosis. CD2-associated protein (CD2AP) is highly…”
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Tyrosine phosphatase SHP-2 is a regulator of p27Kip1 tyrosine phosphorylation by Tossidou, Irini, Dangers, Marc, Koch, Alexandra, Brandt, Dominique T., Schiffer, Mario, Kardinal, Christian

“…Tyrosine phosphorylation of the cell cycle regulator p27 Kip1 plays a crucial role in its binding to cyclin dependent kinases and its subcellular localization…”
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Physiological signals and oncogenesis mediated through Crk family adapter proteins by Feller, Stephan M., Posern, Guido, Voss, Jan, Kardinal, Christian, Sakkab, Dima, Zheng, Jie, Knudsen, Beatrice S.

“…The viral Crk oncogene (v‐Crk) is known to induce sarcomas in chicken and its cellular homologs c‐Crk I, c‐Crk II, and Crk‐like (CRKL) have been implicated in…”
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Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4 by Kardinal, Christian, Dangers, Marc, Kardinal, Angelika, Koch, Alexandra, Brandt, Dominique Tobias, Tamura, Teruko, Welte, Karl

“…We have investigated the role of tyrosine phosphorylation of the cyclin-dependent kinase (cdk) inhibitor p27Kip1 using the acute promyelocytic leukemia cell…”
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Herpesvirus Ateles Gene Product Tio Interacts with Nonreceptor Protein Tyrosine Kinases by Albrecht, J C, Friedrich, U, Kardinal, C, Koehn, J, Fleckenstein, B, Feller, S M, Biesinger, B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells by Sauer, Martin G., Herbst, Jessica, Diekmann, Ulf, Rudd, Christopher E., Kardinal, Christian

“…The clinical potential of transplantation is often reduced by T cell-mediated alloresponses that cause graft rejection or graft-versus-host disease…”
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Tyrosine Phosphatase SHP-1 Acts As a Key Regulator Of Alloresponses In Primary Murine T Cells by Kardinal, Christian, Herbst, Jessica, Diekmann, Ulf, Sauer, Martin G.

“…T cell-mediated alloresponses may result in severe transplantation-related morbidity and mortality such as graft rejection or graft versus host disease. After…”
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Cell‐penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients by Kardinal, Christian, Konkol, Birgit, Schulz, Axel, Posern, Guido, Lin, Hui, Adermann, Knut, Eulitz, Manfred, Estrov, Zeev, Talpaz, Moshe, Arlinghaus, Ralph B., Feller, Stephan M.

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An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5 by Ramachandran, Sheetal, Tran, Doan Duy Hai, Klebba-Faerber, Sabine, Kardinal, Christian, Whetton, Anthony D, Tamura, Teruko

“…In response to DNA damage, transcription is blocked by inhibition of RNA polymerase II activity. The regulation of a preexisting pool of mRNAs, therefore,…”
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Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3 by Ehrhardt, Christina, Kardinal, Christian, Wurzer, Walter J., Wolff, Thorsten, von Eichel-Streiber, Christoph, Pleschka, Stephan, Planz, Oliver, Ludwig, Stephan

“…The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFNβ, which is mainly controlled by the IFN-regulatory factor-3…”
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Tyrosine phosphatase SHP-2 is a regulator of p27(Kip1) tyrosine phosphorylation by Tossidou, Irini, Dangers, Marc, Koch, Alexandra, Brandt, Dominique T, Schiffer, Mario, Kardinal, Christian

“…Tyrosine phosphorylation of the cell cycle regulator p27(Kip1) plays a crucial role in its binding to cyclin dependent kinases and its subcellular…”
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Tyrosine phosphatase SHP-2 is a regulator of p27 Kip1 tyrosine phosphorylation by Tossidou, Irini, Dangers, Marc, Koch, Alexandra, Brandt, Dominique T., Schiffer, Mario, Kardinal, Christian

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Structural Investigation of the Binding of a Herpesviral Protein to the SH3 Domain of Tyrosine Kinase Lck by Schweimer, Kristian, Hoffmann, Silke, Bauer, Finn, Friedrich, Ute, Kardinal, Christian, Feller, Stephan M, Biesinger, Brigitte, Sticht, Heinrich

“…Herpesvirus saimiri codes for a tyrosine kinase interacting protein (Tip) that interacts with both the SH3 domain and the kinase domain of the T-cell-specific…”
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The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif by LEWITZKY, Marc, KARDINAL, Christian, GEHRING, Niels H, SCHMIDT, Enrico K, KONKOL, Birgit, EULITZ, Manfred, BIRCHMEIER, Walter, SCHAEPER, Ute, FELLER, Stephan M

“…The adapter Grb2 is an important mediator of normal cell proliferation and oncogenic signal transduction events. It consists of a central SH2 domain flanked by…”
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Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes by Kardinal, Christian, Konkol, Birgit, Lin, Hui, Eulitz, Manfred, Schmidt, Enrico K., Estrov, Zeev, Talpaz, Moshe, Arlinghaus, Ralph B., Feller, Stephan M.

“…Chronic myelogenous leukemia (CML) is commonly characterized by the presence of the p210Bcr-Abl oncoprotein. Many downstream effectors of Bcr-Abl have been…”
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The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways by VOSS, J, POSERN, G, HANNEMANN, J. R, WIEDEMANN, L. M, TURHAN, A. G, POIREL, H, BERNARD, O. A, ADERMANN, K, KARDINAL, C, FELLER, S. M

“…Inappropriate activation of Abl family kinases plays a crucial role in different human leukaemias. In addition to the well known oncoproteins p190Bcr-Abl and…”
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Rac1 and PAK1 are upstream of IKK- and TBK-1 in the viral activation of interferon regulatory factor-3 by Ehrhardt, Christina, Kardinal, Christian, Wurzer, Walter J, Wolff, Thorsten, von Eichel-Streiber, Christoph, Pleschka, Stephan, Planz, Oliver, Ludwig, Stephan

“…The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta , which is mainly controlled by the IFN-regulatory factor-3…”
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Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G by Posern, G, Zheng, J, Knudsen, B S, Kardinal, C, Müller, K B, Voss, J, Shishido, T, Cowburn, D, Cheng, G, Wang, B, Kruh, G D, Burrell, S K, Jacobson, C A, Lenz, D M, Zamborelli, T J, Adermann, K, Hanafusa, H, Feller, S M

“…Many Src Homology 3 (SH3) domains function as molecular adhesives in intracellular signal transduction. Based on previous ultrastructural studies, short motifs…”
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Targeting Molecular Recognition: Exploring the Dual Role of Functional Pseudoprolines in the Design of SH3 Ligands by Tuchscherer, Gabriele, Grell, Daniel, Tatsu, Yoshiro, Durieux, Patricia, Fernandez-Carneado, Jimena, Hengst, Beatrice, Kardinal, Christian, Feller, Stephan

“…Pseudoprolines (ΨPro) have been developed as tools for inducing bioactive conformations that allow for optimal spatial complementation in protein–protein…”
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