Search Results - "KARCH, Rudolf"

Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations by Tomasiak, Lisa, Karch, Rudolf, Schreiner, Wolfgang

“…Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are…”
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Decision theory for precision therapy of breast cancer by Kenn, Michael, Cacsire Castillo-Tong, Dan, Singer, Christian F., Karch, Rudolf, Cibena, Michael, Koelbl, Heinz, Schreiner, Wolfgang

“…Correctly estimating the hormone receptor status for estrogen (ER) and progesterone (PGR) is crucial for precision therapy of breast cancer. It is known that…”
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Approaching Complete Inhibition of P-Glycoprotein at the Human Blood–Brain Barrier: An (R)-[11C]Verapamil PET Study by Bauer, Martin, Karch, Rudolf, Zeitlinger, Markus, Philippe, Cécile, Römermann, Kerstin, Stanek, Johann, Maier-Salamon, Alexandra, Wadsak, Wolfgang, Jäger, Walter, Hacker, Marcus, Müller, Markus, Langer, Oliver

“…As P-glycoprotein (Pgp) inhibition at the blood–brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron…”
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A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier by Bauer, Martin, Karch, Rudolf, Wulkersdorfer, Beatrix, Philippe, Cécile, Nics, Lukas, Klebermass, Eva-Maria, Weber, Maria, Poschner, Stefan, Haslacher, Helmuth, Jäger, Walter, Tournier, Nicolas, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver

“…The adenosine triphosphate-binding cassette transporters P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are 2 efflux transporters at the…”
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Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[11C]verapamil in elderly vs. young subjects by Bauer, Martin, Wulkersdorfer, Beatrix, Karch, Rudolf, Philippe, Cécile, Jäger, Walter, Stanek, Johann, Wadsak, Wolfgang, Hacker, Marcus, Zeitlinger, Markus, Langer, Oliver

“…Aims The efflux transporter P‐glycoprotein (ABCB1) acts at the blood–brain barrier (BBB) to restrict the distribution of many different drugs from blood to the…”
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Clustering molecular dynamics conformations of the CC’-loop of the PD-1 immuno-checkpoint receptor by Schreiner, Wolfgang, Karch, Rudolf, Cibena, Michael, Tomasiak, Lisa, Kenn, Michael, Pfeiler, Georg

“…Molecular mechanisms within the checkpoint receptor PD-1 are essential for its activation by PD-L1 as well as for blocking such an activation via checkpoint…”
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Molecular dynamics identifies semi-rigid domains in the PD-1 checkpoint receptor bound to its natural ligand PD-L1 by Kenn, Michael, Karch, Rudolf, Tomasiak, Lisa, Cibena, Michael, Pfeiler, Georg, Koelbl, Heinz, Schreiner, Wolfgang

“…Cells in danger of being erroneously attacked by leucocytes express PD-L1 on their surface. These cells activate PD-1 on attacking leucocytes and send them to…”
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Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice by Bauer, Martin, Traxl, Alexander, Matsuda, Akihiro, Karch, Rudolf, Philippe, Cécile, Nics, Lukas, Klebermass, Eva-Maria, Wulkersdorfer, Beatrix, Weber, Maria, Poschner, Stefan, Tournier, Nicolas, Jäger, Walter, Wadsak, Wolfgang, Hacker, Marcus, Wanek, Thomas, Zeitlinger, Markus, Langer, Oliver

“…Organic anion-transporting polypeptides (OATPs) mediate the uptake of various drugs from blood into the liver in the basolateral membrane of hepatocytes…”
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Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study by Karch, Rudolf, Stocsits, Claudia, Ilieva, Nevena, Schreiner, Wolfgang

“…The interaction of antigenic peptides (p) and major histocompatibility complexes (pMHC) with T-cell receptors (TCR) is one of the most important steps during…”
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ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure by El Biali, Myriam, Karch, Rudolf, Philippe, Cécile, Haslacher, Helmuth, Tournier, Nicolas, Hacker, Marcus, Zeitlinger, Markus, Schmidl, Doreen, Langer, Oliver, Bauer, Martin

“…The widely expressed and poly-specific ABC transporters breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1) are co-localized at the blood-brain…”
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The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion by Simeone, Xenia, Karch, Rudolf, Ciuraszkiewicz, Anna, Orr‐Urtreger, Avi, Lemmens‐Gruber, Rosa, Scholze, Petra, Huck, Sigismund

“…Our previous immunoprecipitation analysis of nicotinic acetylcholine receptors (nAChRs) in the mouse superior cervical ganglion (SCG) revealed that…”
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Relative Movements of Domains in Large Molecules of the Immune System by Cibena, Michael, Ribarics, Reiner, Karch, Rudolf, Schreiner, Wolfgang, Ilieva, Nevena

“…Molecular dynamics was used to simulate large molecules of the immune system (major histocompatibility complex class I, presented epitope, T-cell receptor, and…”
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Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes by Ilieva, Nevena, Karch, Rudolf, Kenn, Michael, Ribarics, Reiner, Schreiner, Wolfgang

“…MHC α-helices form the antigen-binding cleft and are of particular interest for immunological reactions. To monitor these helices in molecular dynamics…”
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Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography by Wulkersdorfer, Beatrix, Bauer, Martin, Karch, Rudolf, Stefanits, Harald, Philippe, Cécile, Weber, Maria, Czech, Thomas, Menet, Marie-Claude, Declèves, Xavier, Hainfellner, Johannes A., Preusser, Matthias, Hacker, Marcus, Zeitlinger, Markus, Müller, Markus, Langer, Oliver

“…Background P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters expressed at the blood–brain barrier which…”
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Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier by Bauer, Martin, Karch, Rudolf, Neumann, Friederike, Wagner, Claudia C, Kletter, Kurt, Müller, Markus, Löscher, Wolfgang, Zeitlinger, Markus, Langer, Oliver

“…We attempted to assess regional differences in cerebral P-glycoprotein (P-gp) function by performing paired positron emission tomography (PET) scans with the…”
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In vivo P-glycoprotein function before and after epilepsy surgery by Bauer, Martin, Karch, Rudolf, Zeitlinger, Markus, Liu, Joan, Koepp, Matthias J., Asselin, Marie-Claude, Sisodiya, Sanjay M., Hainfellner, Johannes A., Wadsak, Wolfgang, Mitterhauser, Markus, Müller, Markus, Pataraia, Ekaterina, Langer, Oliver

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Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles by SAUERMANN, Robert, KARCH, Rudolf, JOUKHADAR, Christian, LANGENBERGER, Herbert, KETTENBACH, Joachim, MAYER-HELM, Bernhard, PETSCH, Martina, WAGNER, Claudia, SAUTNER, Thomas, GATTRINGER, Rainer, KARANIKAS, Georgios

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET by Kuntner, Claudia, Bankstahl, Jens P., Bankstahl, Marion, Stanek, Johann, Wanek, Thomas, Stundner, Gloria, Karch, Rudolf, Brauner, Rebecca, Meier, Martin, Ding, Xiaoqi, Müller, Markus, Löscher, Wolfgang, Langer, Oliver

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Optimized arterial trees supplying hollow organs by Schreiner, Wolfgang, Karch, Rudolf, Neumann, Martin, Neumann, Friederike, Szawlowski, Paul, Roedler, Susanne

“…Computer models of arterial trees can be generated from optimization principles using the algorithm of constrained constructive optimization (CCO). Up to now…”
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Staged growth of optimized arterial model trees by Karch, R, Neumann, F, Neumann, M, Schreiner, W

“…There is a marked difference in the structure of the arterial tree between epi- and endocardial layers of the human heart. To model these structural…”
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