Search Results - "KARASAWA, Akira"

Structural basis for subtype-specific inhibition of the P2X7 receptor by Karasawa, Akira, Kawate, Toshimitsu

“…The P2X7 receptor is a non-selective cation channel activated by extracellular adenosine triphosphate (ATP). Chronic activation of P2X7 underlies many health…”
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The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition by Karasawa, Akira, Michalski, Kevin, Mikhelzon, Polina, Kawate, Toshimitsu

“…The P2X7 receptor mediates extracellular ATP signaling implicated in the development of devastating diseases such as chronic pain and cancer. Activation of the…”
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Crystallographic Characterization of Sodium Ions in a Bacterial Leucine/Sodium Symporter by Karasawa, Akira, Liu, Haijiao, Quick, Matthias, Hendrickson, Wayne A., Liu, Qun

“…Na+ is the most abundant ion in living organisms and plays essential roles in regulating nutrient uptake, muscle contraction, and neurotransmission. The…”
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Multi-crystal native-SAD phasing at 5 keV with a helium environment by Karasawa, Akira, Andi, Babak, Fuchs, Martin R, Shi, Wuxian, McSweeney, Sean, Hendrickson, Wayne A, Liu, Qun

“…structure determination from single-wavelength anomalous diffraction using native sulfur or phospho-rus in biomolecules (native-SAD) is an appealing method to…”
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Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells by Karasawa, Akira, Kawate, Toshimitsu

“…The P2X7 receptor is an extracellular ATP-gated ion channel found only in eukaryotes (Bartlett ., 2014). Due to its unique properties among P2X receptors, such…”
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Physicochemical Factors Controlling the Activity and Energy Coupling of an Ionic Strength-gated ATP-binding Cassette (ABC) Transporter by Karasawa, Akira, Swier, Lotteke J.Y.M., Stuart, Marc C.A., Brouwers, Jos, Helms, Bernd, Poolman, Bert

“…Cells control their volume through the accumulation of compatible solutes. The bacterial ATP-binding cassette transporter OpuA couples compatible solute uptake…”
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Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA by Wolters, Justina C, Berntsson, Ronnie P-A, Gul, Nadia, Karasawa, Akira, Thunnissen, Andy-Mark W H, Slotboom, Dirk-Jan, Poolman, Bert

“…The ABC transporter OpuA from Lactococcus lactis transports glycine betaine upon activation by threshold values of ionic strength. In this study, the ligand…”
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Differential regulation of IL-4 expression and degranulation by anti-allergic olopatadine in rat basophilic leukemia (RBL-2H3) cells by Matsubara, Masahiro, Masaki, Shigehiro, Ohmori, Kenji, Karasawa, Akira, Hasegawa, Kazuhide

“…Olopatadine hydrochloride (olopatadine) is an anti-allergic drug that functions as a histamine H 1 antagonist and inhibits both mast cell degranulation and the…”
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Detection of Oligomerization and Conformational Changes in the Na+/H+ Antiporter from Helicobacter pylori by Fluorescence Resonance Energy Transfer by Karasawa, Akira, Tsuboi, Yumi, Inoue, Hiroki, Kinoshita, Rie, Nakamura, Norihiro, Kanazawa, Hiroshi

“…Oligomerization and conformational changes in the Na+/H+ antiporter from Helicobacter pylori (HPNhaA) were studied by means of fluorescence resonance energy…”
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Structural Basis and Molecular Mechanism Underlying P2X7 Receptor Antagonism by Karasawa, Akira, Kawate, Toshimitsu

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Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2 by Mimura, Hideki, Ikemura, Toshihide, Kotera, Osamu, Sawada, Masatsugu, Tashiro, Satoshi, Fuse, Eiichi, Ueno, Kimihisa, Manabe, Haruhiko, Ohshima, Etsuo, Karasawa, Akira, Miyaji, Hiromasa

“…Prostaglandin (PG) D2, a major cyclooxygenase metabolite generated from immunologically stimulated mast cells, is known to induce activation and chemotaxis in…”
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Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice by Tamura, Tadafumi, Masaki, Shigehiro, Ohmori, Kenji, Karasawa, Akira

“…Histamine H1 receptor antagonists have long been prescribed for atopic dermatitis as an adjuvant therapy with topical therapy by local applied steroids…”
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Anti‐apoptotic effect of benidipine, a long‐lasting vasodilating calcium antagonist, in ischaemic/reperfused myocardial cells by Gao, Feng, Gong, Bing, Christopher, Theodore A, Lopez, Bernard L, Karasawa, Akira, Ma, Xin L

“…Ischaemia/reperfusion causes intracellular calcium overloading in cardiac cells. Administration of calcium antagonists reduces myocardial infarct size. Recent…”
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Hardware Performance of PALSAR-3 Onboard ALOS-4 by Okada, Yu, Yokota, Yuya, Karasawa, Akira, Matsuki, Makoto, Arii, Motofumi, Nakamura, Shohei

“…The paper describes hardware performances of PALSAR-3 onboard ALOS-4, which is a follow-on mission of ALOS-2. To implement land deformation and subsidence…”
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Membrane Lipid Compositions Control Dye-Permeable Pore of the P2X7 Receptor by Karasawa, Akira, Michalski, Kevin, Mikhelzon, Polina, Kawate, Toshimitsu

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High-throughput YO-PRO-1 Uptake Assay for P2X7 Receptors Expressed in HEK Cells by Karasawa, Akira, Kawate, Toshimitsu

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Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils by Miyake, Kiyomi, Ohmori, Kenji, Ishii, Akio, Karasawa, Akira

“…Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an…”
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Effects of orally administered olopatadine hydrochloride on the ocular allergic reaction in rats by Tamura, Tadafumi, Sato, Hitoshi, Miki, Ichiro, Suzuki, Kazuo, Ohmori, Kenji, Karasawa, Akira

“…Olopatadine hydrochloride is an antiallergic agent with histamine H1 receptor antagonistic action. We investigated the effects of olopatadine on passive…”
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Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure by Suzuki, Fumio, Shimada, Junichi, Mizumoto, Hideaki, Karasawa, Akira, Kubo, Kazuhiro, Nonaka, Hiromi, Ishii, Akio, Kawakita, Takashi

“…Diuretic activities of xanthine or nonxanthine adenosine antagonists and their ameliorative effects against glycerol-induced acute renal failure in rats were…”
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Effects of olopatadine hydrochloride on the release of thromboxane B2 and histamine from nasal mucosa after antigen–antibody reaction in guinea pigs by Kaise, Toshihiko, Akamatsu, Yukino, Ohmori, Kenji, Ishii, Akio, Karasawa, Akira

“…Various mediators, such as thromboxane (TX) A2, peptide leukotrienes (P-LT) and histamine, are involved in allergic nasal obstruction. The aim of the present…”
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