Search Results - "KARARA, A"

Suicide gene and cytokines combined nonviral gene therapy for spontaneous canine melanoma by Finocchiaro, L M E, Fiszman, G L, Karara, A L, Glikin, G C

“…Canine spontaneous melanoma is a highly aggressive tumor resistant to current therapies. We evaluated the safety, efficacy and antitumor effects of direct…”
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Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin by Hirschberg, Y, Karara, A H, Pietri, A O, McLeod, J F

“…Improved control of mealtime glucose excursions with coadministration of nateglinide and metformin. Y Hirschberg , A H Karara , A O Pietri and J F McLeod…”
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Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet by Makita, K, Takahashi, K, Karara, A, Jacobson, H R, Falck, J R, Capdevila, J H

“…Excess dietary salt induces a cytochrome P450 arachidonic acid epoxygenase isoform in rat kidneys (Capdevila, J. H., S. Wei, J. Yang, A. Karara, H. R…”
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The Effect of Food on the Oral Bioavailability and the Pharmacodynamic Actions of the Insulinotropic Agent Nateglinide in Healthy Subjects by Karara, Adel H., Dunning, Beth E., McLeod, James F.

“…Nateglinide (Starlix®, SDZ DJN 608 or A‐4166), a new insulinotropic agent, is intended to be administered prior to a meal in order to improve early insulin…”
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Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase by KARARA, A, MAKITA, K, JACOBSON, H. R, FALCK, J. R, GUENGERICH, F. P, DUBOIS, R. N, CAPDEVILA, J. H

“…A cDNA containing an open reading frame coding for the rat kidney cytochrome P-450 arachidonic acid epoxygenase was isolated from a male rat kidney cDNA…”
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Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties by Karara, A, Dishman, E, Falck, J R, Capdevila, J H

“…By chromatographic and mass spectral techniques we document in rat liver the presence of new classes of glycerophospholipids which contain an…”
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Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading by Capdevila, J.H., Wei, S, Yan, J, Karara, A, Jacobson, H.R., Falck, J.R., Guengerich, F.P., DuBois, R.N.

“…The rat kidney microsomal epoxygenase catalyzed the asymmetric epoxidation of arachidonic acid to generate as major products: 8(R),9(S)-, 11(R),12(S)- and…”
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Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase by CAPDEVILA, J. H, KARARA, A, WAXMAN, D. J, MARTIN, M. V, FALCK, J. R, GUENGUERICH, F. P

“…Chiral analysis of the rat liver microsomal arachidonic acid epoxygenase metabolites shows enantioselective formation of 8,9-, 11,12-, and…”
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Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase by KARARA, A, DISHMAN, E, BLAIR, I, FALCK, J. R, CAPDEVILA, J. H

“…Chiral analysis of the endogenous rat liver epoxyeicosatrienoic acids shows the biosynthesis of 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids in a 4:1,…”
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Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses by Takahashi, K, Capdevila, J, Karara, A, Falck, J R, Jacobson, H R, Badr, K F

“…Rat kidney cortical and medullary microsomal fractions catalyzed cytochrome P-450-linked metabolism of arachidonic acid (AA) to epoxyeicosatrienoic acids…”
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Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney by Katoh, T, Takahashi, K, Capdevila, J, Karara, A, Falck, J R, Jacobson, H R, Badr, K F

“…Renal glomerular and cortical metabolism of endogenous arachidonic acid by cytochrome P-450 epoxygenase yields 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic…”
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Interleukin 1 alpha inhibits prostaglandin E2 release to suppress pulsatile release of luteinizing hormone but not follicle-stimulating hormone by RETTORI, V, GIMENO, M. F, KARARA, A, GONZALEZ, M. C, MCCANN, S. M

“…Interleukin 1 alpha (IL-1 alpha), a powerful endogenous pyrogen released from monocytes and macrophages by bacterial endotoxin, stimulates corticotropin,…”
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Effect of food on the bioavailability of SDZ DJN 608, an oral hypoglycemic agent, from a tablet and a liquid-filled capsule in the dog by TSE, F. L. S, LABBADIA, D, HABUCKY, K, KARARA, A, AU, S

“…The effect on food on the bioavailability of SDZ DJN 608, a D-phenylalanine derivative, was investigated in three mature, male beagle dogs. Each dog received,…”
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Metabolic inhibition and di-2-ethylhexyl phthalate pharmacokinetics in fish by Karara, A H, Hayton, W L

“…A pharmacokinetic model for the accumulation of di-2-ethylhexyl phthalate (DEHP) by sheepshead minnow predicted a significant increase in the bioconcentration…”
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Pharmacokinetics of abecarnil in patients with renal insufficiency by Karara, A H, Frye, R F, Hayes, P E, Weaver, M L, Robinson, W T, Rault, R M, Matzke, G R

“…To characterize the pharmacokinetics of a single 5 mg oral dose of abecarnil in subjects with varying degrees of renal impairment. Twenty-six subjects were…”
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Single-Dose Pharmacokinetics of Sotalol in a Pediatric Population with Supraventricular and/or Ventricular Tachyarrhythmia by Saul, J. Philip, Schaffer, Michael S., Karpawich, Peter P., Erickson, Christopher C., Epstein, Michael R., Melikian, Armen P., Shi, Jun, Karara, Adel H., Cai, Bin, Hinderling, Peter H.

“…The pharmacokinetics (PK) of the antiarrhythmic sotalol, which elicits Class III and beta‐blocking activity, has not been adequately defined in a pediatric…”
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Effect of 2-hydroxypropyl-β-cyclodextrin on the ocular absorption of dexamethasone and dexamethasone acetate by USAYAPANT, A, KARANA, A. H, NARURKAR, M. M

“…Complexation of dexamethasone (DX) and dexamethasone acetate (DXA) with 2-hydroxypropyl-beta-cyclodextrin (HPCD) was investigated with an ultimate goal of…”
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Inhibition of water-sodium intestinal absorption by an atrial extract by Martïnez Seeber, A, Vidal, N A, Carchio, S M, Karara, A L

“…The rat atrium contains a diuretic and natriuretic factor which appears to inhibit the sodium reabsorption in the kidney tubules. We observed, in rats, that…”
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Pharmacokinetic model for the disposition of 3-methylcholanthrene in channel catfish after slow intraaortic infusion by SOMESH CHOUDHURY, KARARA, A. H, ACE, L. N

“…An inducer of hepatic microsomal oxygenases, 3-methylcholanthrene (3MC), was infused into channel catfish through the dorsal aorta during 2.2-2.7 h to a final…”
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Pharmacokinetics of SDZ 64-412, a novel antiasthmatic agent, following intravenous, oral, and inhalation dosing in the rat by Charnick, S B, Yu, Z, Athill, L V, Karara, A H, Tse, F L, Lau, D T

“…The pharmacokinetics of SDZ 64-412, an antiasthmatic agent, were investigated following intravenous, oral, and inhalation dosing in rats. 14C-SDZ 64-412 was…”
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