Search Results - "KARAMANOS, N. K"

Insights into targeting colon cancer cell fate at the level of proteoglycans / glycosaminoglycans by Nikitovic, D, Chatzinikolaou, G, Tsiaoussis, J, Tsatsakis, A, Karamanos, N K, Tzanakakis, G N

“…Proteoglycans (PGs), glycosaminoglycans (GAGs) and hyaluronan as a free GAG, have unique structural characteristics which enable them via specific interactions…”
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Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab by Gialeli, Ch, Theocharis, A. D., Kletsas, D., Tzanakakis, G. N., Karamanos, N. K.

“…Summary The epidermal growth factor receptor (EGFR) is a member of the HER family receptors and its activation induced by its natural ligand EGF results in…”
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Targeting the tumor proteasome as a mechanism to control the synthesis and bioactivity of matrix macromolecules by Skandalis, S S, Aletras, A J, Gialeli, C, Theocharis, A D, Afratis, N, Tzanakakis, G N, Karamanos, N K

“…Extracellular matrices (ECMs) are dynamic structures that provide cells not only with a structural support but, importantly, exhibit significant functional…”
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Could growth factor-mediated extracellular matrix deposition and degradation offer the ground for directed pharmacological targeting in fibrosarcoma? by Nikitovic, D, Berdiaki, A, Banos, A, Tsatsakis, A, Karamanos, N K, Tzanakakis, G N

“…The specific organization of the tumor extracellular matrix (ECM) is an intrinsic and basic step in the convoluted pathways of tumorigenesis. Fibrosarcoma is a…”
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Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors by Kousidou, O C, Mitropoulou, T N, Roussidis, A E, Kletsas, D, Theocharis, A D, Karamanos, N K

“…Progression of breast cancer implicates the degradation of extracellular matrix (ECM) by metallo-proteinases (MMPs), a process with important consequences on…”
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Effects of Glycosaminoglycans on Cell Proliferation of Normal Osteoblasts and Human Osteosarcoma Cells Depend on their Type and Fine Chemical Compositions by NIKITOVIC, D, ZAFIROPOULOS, A, TZANAKAKIS, G. N, KARAMANOS, N. K, TSATSAKIS, A. M

“…Osteoblastic cells produce a complex extracellular matrix (ECM) composed of a mixture of proteoglycans (PGs), collagens and non-collagenous proteins. The…”
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The importance of c-Kit and PDGF receptors as potential targets for molecular therapy in breast cancer by Roussidis, A E, Theocharis, A D, Tzanakakis, G N, Karamanos, N K

“…Molecular therapies target key functional molecules in order to halter viable operation of cancer cells. Receptor tyrosine kinases (RTKs) constitute attractive…”
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The role of oligodendrocytes in the molecular pathobiology and potential molecular treatment of cervical spondylotic myelopathy by Karadimas, S K, Gialeli, C H, Klironomos, G, Tzanakakis, G N, Panagiotopoulos, E, Karamanos, N K, Gatzounis, G

“…Cervical spondylotic myelopathy (CSM) is a very common and debilitating disease; however, its underlying pathocellular process remains uncertain. Attempts have…”
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Expression of MMPs and TIMPs Genes in Human Breast Cancer Epithelial Cells Depends on Cell Culture Conditions and is Associated with their Invasive Potential by KOUSIDOU, O. Ch, ROUSSIDIS, A. E, THEOCHARIS, A. D, KARAMANOS, N. K

“…Growth and invasiveness of breast cancer cells in adjacent and distant sites is associated with the expression of metalloproteinases (MMPs), which are capable…”
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Versican but not decorin accumulation is related to metastatic potential and neovascularization in testicular germ cell tumours by Labropoulou, V T, Theocharis, A D, Ravazoula, P, Perimenis, P, Hjerpe, A, Karamanos, N K, Kalofonos, H P

“…Aims:  To investigate the expression of versican and decorin in patients with testicular germ cell tumours (GCTs) and to correlate this with the…”
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Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours by Milia-Argeiti, E., Huet, E., Labropoulou, V. T., Mourah, S., Fenichel, P., Karamanos, N. K., Menashi, S., Theocharis, A. D.

“…Summary The histological classification of testicular germ cell tumours (TGCTs) to seminoma or non‐seminomatous germ cell tumours is at present the main…”
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Transforming Growth Factor‐β as a key molecule triggering the expression of versican isoforms v0 and v1, Hyaluronan Synthase‐2 and synthesis of Hyaluronan in Malignant Osteosarcoma cells by Nikitovic, D., Zafiropoulos, A., Katonis, P., Tsatsakis, A., Theocharis, A. D., Karamanos, N. K., Tzanakakis, G. N.

“…Versican, a large sized chondroitin‐sulphate proteoglycan (PG), and its binding partner, hyaluronan (HA), are extracellular matrix (ECM) components that play…”
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Heparan sulfate proteoglycans and heparin regulate melanoma cell functions by Nikitovic, D., Mytilinaiou, M., Berdiaki, Ai, Karamanos, N.K., Tzanakakis, G.N.

“…The solid melanoma tumor consists of transformed melanoma cells, and the associated stromal cells including fibroblasts, endothelial cells, immune cells, as…”
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Evaluation of modal damping factor as a diagnostic tool for osteoporosis and its relation with serum osteocalcin and collagen I N-telopeptide for monitoring the efficacy of alendronate in ovariectomized rats by Christopoulou, G.E., Stavropoulou, A., Anastassopoulos, G., Panteliou, S.D., Papadaki, E., Karamanos, N.K., Panagiotopoulos, E.

“…Osteoporosis is a metabolic bone disease characterized by reduced bone mass and deterioration of bone microarchitecture. It results from the shift of the…”
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Protein Tyrosine Kinase and Estrogen Receptor-dependent Pathways Regulate the Synthesis and Distribution of Glycosaminoglycans/Proteoglycans Produced by Two Human Colon Cancer Cell Lines by CHATZINIKOLAOU, G, NIKITOVIC, D, STATHOPOULOS, E. N, VELEGRAKIS, G. A, KARAMANOS, N. K, TZANAKAKIS, G. N

“…The soy isoflavone genistein can affect cell metabolism by specifically inhibiting protein tyrosine kinase (PTK) and/or interacting with the estrogen receptors…”
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Determination and biological relevance of serum cross-linked type I collagen N-telopeptide and bone-specific alkaline phosphatase in breast metastatic cancer by Kanakis, I., Nikolaou, M., Pectasides, D., Kiamouris, C., Karamanos, N.K.

“…Bone metastasis is a frequent complication of cancer disease. The metastatic spread of cancer to bone is common to many different malignancies, particularly…”
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Effects of the natural isoflavonoid genistein on growth, signaling pathways and gene expression of matrix macromolecules by breast cancer cells by Kousidou, O Ch, Tzanakakis, G N, Karamanos, N K

“…Genistein is a well known protein tyrosine kinase inhibitor. It is structurally similar to 17beta-estradiol and exerts antiestrogenic effects. It also affects…”
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Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid by Dedes, P.G., Gialeli, Ch, Tsonis, A.I., Kanakis, I., Theocharis, A.D., Kletsas, D., Tzanakakis, G.N., Karamanos, N.K.

“…The extracellular matrix (ECM) components play key roles in the multistep process of cancer growth and progression. Preclinical and clinical data show that…”
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Advances in analysis of glycosaminoglycans: its application for the assessment of physiological and pathological states of connective tissues by Vynios, D.H, Karamanos, N.K, Tsiganos, C.P

“…Glycosaminoglycans are a class of biological macromolecules found mainly in connective tissues as constituents of proteoglycans, covalently linked to their…”
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Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells by Gialeli, Ch, Viola, M., Barbouri, D., Kletsas, D., Passi, A., Karamanos, N.K.

“…Breast cancer–endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the…”
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