Search Results - "KARALI, Nilgün"

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII by Güzel-Akdemir, Özlen, Akdemir, Atilla, Karalı, Nilgün, Supuran, Claudiu T

“…A series of 2/3/4-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)amino]benzenesulfonamides, obtained from substituted isatins and 2-, 3- or 4-aminobenzenesulfonamide,…”
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Histone deacetylase inhibitors providing an epigenetic treatment in cancer by Cinek,Tuğçe, Karalı,Nilgün

“…Cancer is among the leading causes of death worldwide and is therefore one of the diseases in which there have been major medical advances and which is the…”
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Synthesis and structure-antituberculosis activity relationship of 1H-indole-2,3-dione derivatives by KARALI, Nilgün, GÜRSOY, Aysel, KANDEMIRLI, Fatma, SHVETS, Nathaly, BETÜL KAYNAK, F, OZBEY, Süheyla, KOVALISHYN, Vasyl, DIMOGLO, Anatholy

“…New series of 5-fluoro-1H-indole-2,3-dione-3-thiosemicarbazones 2a-k and 5-fluoro-1-morpholino/piperidinomethyl-1H-indole-2,3-dione-3-thiosemicarbazones 3a-r…”
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Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones by Sevinçli, Zekiye Şeyma, Duran, Gizem Nur, Özbil, Mehmet, Karalı, Nilgün

“…[Display omitted] •26 new 1-alkylated 5-fluoroisatin 3-thiosemicarbazone derivatives were synthesized.•Some derivatives were found effective against herpes…”
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Synthesis and primary antiviral activity evaluation of 3-hydrazono-5-nitro-2-indolinone derivatives by Terzioglu, Nalan, Karali, Nilgün, Gürsoy, Aysel, Pannecouque, Christophe, Leysen, Pieter, Paeshuyse, Jan, Neyts, Johan, Clercq, Erik De

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Antiviral activity and molecular modeling studies on 1H-indole-2,3-diones carrying a naphthalene moiety by Soylu-Eter, Özge, Duran, Gizem Nur, Özbil, Mehmet, Göktaş, Füsun, Cihan-Üstündağ, Gökçe, Karalı, Nilgün

“…•1H-indole-2,3-diones (2a-f) bearing a naphthalene ring were synthesized.•The antiviral effects of 2a-f were evaluated against different DNA and RNA…”
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Bioisosterism: 1,2,4‐Oxadiazole Rings by Camci, Merve, Karali, Nilgün

“…Although studies in drug discovery have gained momentum in recent years, the conversion of drugs in use today into less toxic derivatives with…”
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Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases by Karalı, Nilgün, Akdemir, Atilla, Göktaş, Füsun, Eraslan Elma, Pınar, Angeli, Andrea, Kızılırmak, Merih, Supuran, Claudiu T.

“…[Display omitted] Human carbonic anhydrases IX and XII are upregulated in many tumors and form a novel target for new generation anticancer drugs. Here we…”
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Synthesis and molecular modeling studies of 1-benzyl-2-indolinones as selective AChE inhibitors by Apaydın, Çağla Begüm, Soylu-Eter, Özge, Eraslan-Elma, Pınar, Özsoy, Nurten, Karalı, Nilgün

“…Possible bioisosteres can be developed by replacing the 1-indanone ring (one of three pharmacophore groups) of donepezil with an indoline ring. As H S donors,…”
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New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors by Eraslan‐Elma, Pınar, Akdemir, Atilla, Berrino, Emanuela, Bozdağ, Murat, Supuran, Claudiu T., Karalı, Nilgün

“…1‐Methyl/ethyl/benzyl‐5‐(un)substituted 1H‐indole‐2,3‐diones (2, 3, and 4) were synthesized by reaction of 5‐(un)substituted 1H‐indole‐2,3‐diones (1) with…”
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Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes by Akdemir, Atilla, Güzel-Akdemir, Özlen, Karalı, Nilgün, Supuran, Claudiu T.

“…[Display omitted] Enzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1)…”
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Anti-proliferative effects of indomethacin, acemetacin and their tromethamine salts in HCT116 human colon cancer cells by Cihan Üstündağ,Gökçe, Somuncu,Berna, Müftüoğlu,Meltem, Karalı,Nilgün

“…Background and Aims: Since 1980's, several preclinical studies have been published on the anti-colorectal cancer activity of the nonsteroidal anti-inflammatory…”
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5‐Fluoro/(trifluoromethoxy)‐2‐indolinone derivatives with anti‐interleukin‐1 activity by Soylu‐Eter, Özge, Sevinçli, Zekiye Şeyma, Ersoy, Betül, Hasanusta, Bahar, Gatfar, Uğur, Lack, Nathan A., Erman, Burak, Gül, Ahmet, Orer, Hakan S., Karalı, Nilgün

“…The pro‐inflammatory cytokine interleukin‐1 (IL‐1) drives the pathogenesis of several inflammatory diseases. Recent studies have revealed that 2‐indolinones…”
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Synthesis, molecular modeling and cholinesterase inhibitory effects of 2-indolinone-based hydrazinecarbothioamides by Demir-Yazıcı, Kübra, Apaydın, Çağla Begüm, Soylu-Eter, Özge, Özsoy, Nurten, Karalı, Nilgün

“…2-Indolinone-based hydrazinecarbothioamides carrying a 3-phenylsulfonamide moiety ( ) were designed by replacement of donepezil's pharmacophore group indanone…”
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Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme by Akdemir, Atilla, Angeli, Andrea, Göktaş, Füsun, Eraslan Elma, Pınar, Karalı, Nilgün, Supuran, Claudiu T.

“…Inhibition of the β-carbonic anhydrase (CA, EC 4.2.1.1) from pathogenic Candida glabrata (CgNce103) by 1H-indole-2,3-dione…”
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Molecular and crystal structure of 1-methyl- 5-trifluoromethoxy-1H-indole-2,3-dione 3-[4-(4-methoxyphenyl)thiosemicarbazone] by Soylu Eter,Özge, Atioğlu,Zeliha, Akkurt,Mehmet, Ersanlı,Cem Cüneyt, Karalı,Nilgün

“…Background and Aims: The main purpose of this study is to determine the molecular structure and isomers of the new 1-methyl-…”
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Anticancer and antituberculosis effects of 5-fluoro- 1H-indole-2,3-dione 3-thiosemicarbazones by Sevinçli,Zekiye Şeyma, Cantürk,Zerrin, Dikmen,Miriş, Karalı,Nilgün

“…Background and Aims: The aim of this study was to screen the in vitro anticancer/antituberculosis activities of 5-fluoro- 1-methyl/ethyl-1H-indole-2,3-dione…”
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Three novel compounds of 5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone: Synthesis, crystal structures and molecular interactions by Kaynak, Filiz Betül, Özbey, Süheyla, Karalı, Nilgün

“…•5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives were synthesized.•The structures were determined by analytical, spectral and single XRD…”
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Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2,3-dione 3-Thiosemicarbazone Derivatives on Lymphoid-originated Cells by Danışman-Kalındemirtaş, Ferdane, Erdem-Kuruca, Serap, Akgün-Dar, Kadriye, Karakaş, Zeynep, Soylu, Özge, Karali, Nilgün

“…The present study aims to identify the anticancer effect of novel 1H-indole-2,3-dione 3- thiosemicarbazone derivatives. These compounds could be promising…”
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Anticancer activities and cell death mechanisms of 1H-indole-2,3-dione 3-[N-(4 sulfamoylphenyl)thiosemicarbazone] derivatives by Çetin,İdil, Topçul,Mehmet Rıfkı, Eraslan Elma,Pınar, Karalı,Nilgün

“…In this study, the cytotoxic effects of 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazone derivatives namely, 4a-d were evaluated using cell…”
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