Search Results - "KARAKASHIAN, A"

Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes by El-Amouri, S., Karakashian, A., Bieberich, E., Nikolova-Karakashian, M.

“…Obesity-associated diabetes is linked to the accumulation of ceramide in various organs, including the liver. The exact mechanisms by which ceramide…”
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Fully discrete dynamic mesh discontinuous Galerkin methods for the Cahn-Hilliard equation of phase transition by Feng, Xiaobing, Karakashian, Ohannes A.

“…Fully discrete discontinuous Galerkin methods with variable mesh-\linebreak es in time are developed for the fourth order Cahn-Hilliard equation arising from…”
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Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism by Shi, L, Banerjee, D, Dobierzewska, A, Sathishkumar, S, Karakashian, A A, Giltiay, N V, Nikolova-Karakashian, M N

“…The level of insulin-like growth factor-binding protein 1 (IGFBP1), a liver-produced serum protein that regulates insulin-like growth factor-I bioactivity,…”
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Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state by Dotson, 2nd, P Patrick, Karakashian, Alexander A, Nikolova-Karakashian, Mariana N

“…Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a…”
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A Posteriori Error Estimates for a Discontinuous Galerkin Approximation of Second-Order Elliptic Problems by Karakashian, Ohannes A., Pascal, Frederic

“…Several a posteriori error estimators are introduced and analyzed for a discontinuous Galerkin formulation of a model second-order elliptic problem. In…”
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Expression of neutral sphingomyelinase‐2 (NSMase‐2) in primary rat hepatocytes modulates IL‐β‐induced JNK activation by Karakashian, Alexander A., Giltiay, Natalia V., Smith, George M., Nikolova-Karakashian, Mariana N.

“…ABSTRACT Neutral sphingomyelinase (NSMase) has been proposed to mediate interleukin (IL)‐1β signaling in liver. In this paper, we used adenovirus‐mediated gene…”
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Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis by Sathishkumar, Sabapathi, Boyanovski, Boris, Karakashian, Alexander, Rozenova, Krassimira A., Giltiay, Natalia V., Kudrimoti, Mahesh, Mohiuddin, Mohammed, Ahmed, Mansoor M., Nikolova-Karakashian, Mariana

“…Spatially Fractionated high dose (Grid) Radiation Treatment (SFGRT) involves irradiation of bulky tumors with one high, grid-delivered, dose of 15 Gy followed…”
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Two-Level Additive Schwarz Methods for a Discontinuous Galerkin Approximation of Second Order Elliptic Problems by Feng, Xiaobing, Karakashian, Ohannes A.

“…We present some two-level nonoverlapping and overlapping additive Schwarz methods for a discontinuous Galerkin method for solving second order elliptic…”
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Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1β in hepatocytes by Giltiay, Natalia V., Karakashian, Alexander A., Alimov, Alexander P., Ligthle, Sandy, Nikolova-Karakashian, Mariana N.

“…Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including…”
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Convergence of Adaptive Discontinuous Galerkin Approximations of Second-Order Elliptic Problems by Karakashian, Ohannes A., Pascal, Frederic

“…A residual-type a posteriori error estimator is introduced and analyzed for a discontinuous Galerkin formulation of a model second-order elliptic problem with…”
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Two-Level Non-Overlapping Schwarz Preconditioners for a Discontinuous Galerkin Approximation of the Biharmonic Equation by Feng, Xiaobing, Karakashian, Ohannes A.

“…We present some two-level non-overlapping additive and multiplicative Schwarz methods for a discontinuous Galerkin method for solving the biharmonic equation…”
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A Nonconforming Finite Element Method for the Stationary Navier-Stokes Equations by Karakashian, Ohannes A., Jureidini, Wadi N.

“…Approximations to solutions of the inhomogeneous boundary value problem for the Navier-Stokes equations are constructed via a nonstandard finite element…”
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Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages by Rozenova, Krasimira A., Deevska, Gergana M., Karakashian, Alexander A., Nikolova-Karakashian, Mariana N.

“…Acid sphingomyelinase (ASMase) has been proposed to mediate lipopolysaccharide (LPS) signaling in various cell types. This study shows that ASMase is a…”
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Novel Interconnections in Lipid Metabolism Revealed by Overexpression of Sphingomyelin Synthase-1 by Deevska, Gergana M., Dotson, Patrick P., Karakashian, Alexander A., Isaac, Giorgis, Wrona, Mark, Kelly, Samuel B., Merrill, Alfred H., Nikolova-Karakashian, Mariana N.

“…This study investigates the consequences of elevating sphingomyelin synthase 1 (SMS1) activity, which generates the main mammalian sphingolipid, sphingomyelin…”
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Primary Care Provider Perspectives on Virtual and In-Person Depression Management During the COVID-19 Pandemic by Leung, Lucinda B., Chrystal, Joya G., Dyer, Karen E., Brayton, Catherine E., Karakashian, Michael A., Yano, Elizabeth M., Young, Alexander S., Shekelle, Paul G., Hamilton, Alison B.

“…Introduction: During the COVID-19 pandemic, primary care providers (PCPs), nurses, and integrated mental health specialists continued to collaboratively manage…”
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Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism by Dobierzewska, Aneta, Shi, Lihua, Karakashian, Alexander A, Nikolova-Karakashian, Mariana N

“…FoxO1 transcription factor controls the glucose and lipid metabolism, as well as cell proliferation and stress response. Akt, activated by insulin and other…”
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Conservative, high-order numerical schemes for the generalized Korteweg—de Vries equation by Bona, J. L., Dougalis, V. A., Karakashian, O. A., McKinney, W. R., Smith, F. T.

“…A class of fully discrete schemes for the numerical simulation of solutions of the periodic initial-value problem for a class of generalized Korteweg-de Vries…”
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Outcomes of Spatially Fractionated Radiotherapy (GRID) for Bulky Soft Tissue Sarcomas in a Large Animal Model by Nolan, Michael W., Gieger, Tracy L., Karakashian, Alexander A., Nikolova-Karakashian, Mariana N., Posner, Lysa P., Roback, Donald M., Rivera, Judith N., Chang, Sha

“…GRID directs alternating regions of high- and low-dose radiation at tumors. A large animal model mimicking the geometries of human treatments is needed to…”
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Protective Behavioral Strategies and the Relationship Between Depressive Symptoms and Alcohol-Related Negative Consequences Among College Students by Martens, Matthew P, Martin, Jessica L, Hatchett, E. Suzanne, Fowler, Roneferiti M, Fleming, Kristie M, Karakashian, Michael A, Cimini, M. Dolores

“…Approximately 40% of college students reported engaging in heavy episodic or "binge" drinking in the 2 weeks prior to being surveyed. Research indicates that…”
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On fully discrete Galerkin methods of second-order temporal accuracy for the nonlinear Schrödinger equation by AKRIVIS, G. D, DOUGALIS, V. A, KARAKASHIAN, O. A

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