Search Results - "KARADIMITRIS, A"

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma by Barbarulo, A, Iansante, V, Chaidos, A, Naresh, K, Rahemtulla, A, Franzoso, G, Karadimitris, A, Haskard, D O, Papa, S, Bubici, C

“…Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM…”
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Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97 by Parzych, K, Chinn, T M, Chen, Z, Loaiza, S, Porsch, F, Valbuena, G N, Kleijnen, M F, Karadimitris, A, Gentleman, E, Keun, H C, Auner, H W

“…The cellular mechanisms that control protein degradation may constitute a non-oncogenic cancer cell vulnerability and, therefore, a therapeutic target…”
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SUN-LB040: Overweight, Obesity and Risk of Non-Hodgkin Lymphoma: A Meta-Analysis of Cohort Studies by Psaltopoulou, T, Sergentanis, T.N, Ntanasis-Stathopoulos, I, Tzanninis, I.-G, Zagouri, F, Karadimitris, A

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Overexpression of RANKL by invariant NKT cells enriched in the bone marrow of patients with multiple myeloma by Spanoudakis, E, Papoutselis, M, Terpos, E, Dimopoulos, M A, Tsatalas, C, Margaritis, D, Rahemtulla, A, Kotsianidis, I, Karadimitris, A

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The cellular pathogenesis of paroxysmal nocturnal haemoglobinuria by KARADIMITRIS, A, LUZZATTO, L

“…Paroxysmal nocturnal haemoglobinuria (PNH) is a unique disorder characterised by the triad of intravascular haemolysis, thrombosis and bone marrow failure. In…”
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LB019-MON: Obesity and Risk for Hodgkin’s Lymphoma: A Meta-Analysis of Prospective Studies by Psaltopoulou, T, Sergentanis, T.N, Ntanasis-Stathopoulos, I, Tzanninis, I.-G, Karadimitris, A, Dimopoulos, M.-A

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Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria by Karadimitris, Anastasios, Manavalan, John S., Thaler, Howard T., Notaro, Rosario, Araten, David J., Nafa, Khedoudja, Roberts, Irene A.G., Weksler, Marc E., Luzzatto, Lucio

“…Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell (HSC). Somatic mutations in thePIG-Agene result in the…”
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Dynamics of hematopoiesis in paroxysmal nocturnal hemoglobinuria (PNH): no evidence for intrinsic growth advantage of PNH clones by ARATEN, D. J, BESSLER, M, MCKENZIE, S, CASTRO-MALASPINA, H, CHILDS, B. H, BOULAD, F, KARADIMITRIS, A, NOTARO, R, LUZZATTO, L

“…PNH is characterized by expansion of one or more stem cell clones with a PIG-A mutation, which causes a severe deficiency in the expression of…”
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PNH cells are as sensitive to T-cell-mediated lysis as their normal counterparts : implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria by KARADIMITRIS, Anastasios, NOTARO, Rosario, KOEHNE, Gunther, ROBERTS, Irene A. G, LUZZATTO, Lucio

“…The mechanism responsible for the bone marrow failure that is almost invariable in paroxysmal nocturnal haemoglobinuria (PNH) is unknown. Based on the close…”
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SUN-LB326: Overweight, Obesity and Risk of Leukemia in Adults: A Meta-Analysis of Cohort Studies by Psaltopoulou, T., Ntanasis-Stathopoulos, I., Tzanninis, I.-G., Sergentanis, I.N., Karadimitris, A., Sergentanis, T.N.

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Poly is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma by Barbarulo, A, Iansante, V, Chaidos, A, Naresh, K, Rahemtulla, A, Franzoso, G, Karadimitris, A, Haskard, D.O, Papa, S, Bubici, C

“…Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM…”
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Human CD1d-Glycolipid Tetramers Generated by in vitro Oxidative Refolding Chromatography by Karadimitris, Anastasios, Gadola, Stephan, Altamirano, Myriam, Brown, Dave, Woolfson, Adrian, Klenerman, Paul, Chen, Ji-Li, Koezuka, Yasuhiko, Irene A. G. Roberts, Price, David A., Dusheiko, Geoff, Milstein, César, Fersht, Alan, Luzzatto, Lucio, Cerundolo, Vincenzo

“…CD1 molecules are specialized in presenting lipids to T lymphocytes, but identification and isolation of CD1-restricted lipid-specific T cells has been…”
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No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib by Politou, Marianna, Karadimitris, Anastasios, Terpos, Evangelos, Kotsianidis, Ioannis, Apperley, Jane F., Rahemtulla, Amin

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Dyskeratosis and ribosomal rebellion by Luzzatto, Lucio, Karadimitris, Anastasios

“…Dyskeratosis congenita (DC) is a rare inherited X-linked disorder with a spectrum of clinical manifestations that includes--by definition--remarkable changes…”
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Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression by Marktel, S, Marin, D, Foot, N, Szydlo, R, Bua, M, Karadimitris, A, De Melo, VA, Kotzampaltiris, P, Dazzi, F, Rahemtulla, A, Olavarria, E, Apperley, JF, Goldman, JM

“…Department of Hematology, Imperial College at Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. BACKGROUND AND OBJECTIVES: The acquisition of additional…”
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Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria by Karadimitris, Anastasios, Manavalan, John S., Thaler, Howard T., Notaro, Rosario, Araten, David J., Nafa, Khedoudja, Roberts, Irene A.G., Weksler, Marc E., Luzzatto, Lucio

“…Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell (HSC). Somatic mutations in thePIG-A gene result in the…”
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Kinetics, function and bone marrow trafficking of CD4 super(+) CD25 super(+) FOXP3 super(+) regulatory T cells in myelodysplastic syndromes (MDS) by Kotsianidis, I, Bouchliou, I, Nakou, E, Spanoudakis, E, Margaritis, D, Christophoridou, A V, Anastasiades, A, Tsigalou, C, Bourikas, G, Karadimitris, A, Tsatalas, C

“…CD4 super(+) CD25 super(+) FOXP3 super(+) T regulatory cells (T sub(regs)) prevent autoimmunlty by restricting overexuberant immune responses, but the same…”
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Kinetics, function and bone marrow trafficking of [CD4.sup.+][CD25.sup.+][FOXP3.sup.+] regulatory T cells in myelodysplastic syndromes (MDS) by Kotsianidis, I, Bouchliou, I, Nakou, E, Spanoudakis, E, Margaritis, D, Christophoridou, A.V, Anastasiades, A, Tsigalou, C, Bourikas, G, Karadimitris, A, Tsatalas, C

“…[CD4.sup.+][CD25.sup.+][FOXP3.sup.+] T regulatory cells ([T.sub.regs]) prevent autoimmunity by restricting overexuberant immune responses, but the same…”
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Kinetics, function and bone marrow trafficking of CD4 CD25 FOXP3 regulatory T cells in myelodysplastic syndromes (MDS) by Kotsianidis, I, Bouchliou, I, Nakou, E, Spanoudakis, E, Margaritis, D, Christophoridou, A V, Anastasiades, A, Tsigalou, C, Bourikas, G, Karadimitris, A, Tsatalas, C

“…CD4 + CD25 + FOXP3 + T regulatory cells (T regs ) prevent autoimmunity by restricting overexuberant immune responses, but the same subpopulation can incur…”
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Targeted Molecular Therapy for Inherited Glycosylphosphatidylinositol Deficiency by Almeida, A.M., Murakami, Y., Baker, A., Maeda, Y., Roberts, Irene, Kinoshita, Taroh, Layton, D.M., Karadimitris, A.

“…Inherited glycosylphosphatidylinositol (GPI) deficiency (IGD) is an autosomal recessive disease characterized by splanchnic vein thrombosis and epilepsy. The…”
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