Search Results - "KAPPES, Barbara"

Flavogenomics – a genomic and structural view of flavin‐dependent proteins by Macheroux, Peter, Kappes, Barbara, Ealick, Steven E.

“…Riboflavin (vitamin B2) serves as the precursor for FMN and FAD in almost all organisms that utilize the redox‐active isoalloxazine ring system as a coenzyme…”
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Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria by Çapcı, Aysun, Lorion, Mélanie M., Wang, Hui, Simon, Nina, Leidenberger, Maria, Borges Silva, Mariana C., Moreira, Diogo R. M., Zhu, Yongping, Meng, Yuqing, Chen, Jia Yun, Lee, Yew Mun, Friedrich, Oliver, Kappes, Barbara, Wang, Jigang, Ackermann, Lutz, Tsogoeva, Svetlana B.

“…A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved…”
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Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis by Dick, Thomas, Manjunatha, Ujjini, Kappes, Barbara, Gengenbacher, Martin

“…With 500 000 cases of multidrug‐resistant tuberculosis there is an urgent need for attractive targets to enable the discovery of novel antimycobacterials. The…”
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Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission by Auernheimer, Vera, Lautscham, Lena A, Leidenberger, Maria, Friedrich, Oliver, Kappes, Barbara, Fabry, Ben, Goldmann, Wolfgang H

“…The focal adhesion protein vinculin connects the actin cytoskeleton, through talin and integrins, with the extracellular matrix. Vinculin consists of a…”
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PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations by Simon, Nina, Voigtländer, Cornelia, Kappes, Barbara, Rohrbach, Petra, Friedrich, Oliver

“…Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with 'de novo' ability…”
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Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum, Human Cytomegalovirus, and Leukemia Cells by Fröhlich, Tony, Reiter, Christoph, Ibrahim, Mohammad M, Beutel, Jannis, Hutterer, Corina, Zeitträger, Isabel, Bahsi, Hanife, Leidenberger, Maria, Friedrich, Oliver, Kappes, Barbara, Efferth, Thomas, Marschall, Manfred, Tsogoeva, Svetlana B

“…Many quinazoline derivatives have been synthesized over the last few decades with great pharmacological potential, such as antimalarial, anti-inflammatory,…”
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Access to Artemisinin–Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites by Herrmann, Lars, Leidenberger, Maria, Quadros, Helenita C., Grau, Benedikt W., Hampel, Frank, Friedrich, Oliver, Moreira, Diogo R. M., Kappes, Barbara, Tsogoeva, Svetlana B.

“…Malaria is one of the most widespread diseases worldwide. Besides a growing number of people potentially threatened by malaria, the consistent emergence of…”
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Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites by Müller, Sylke, Kappes, Barbara

“…Vitamins are essential components of the human diet. By contrast, the malaria parasite Plasmodium falciparum and related apicomplexan parasites synthesize…”
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Identification and Characterization of Novel Small Molecules as Potent Inhibitors of the Plasmodial Calcium-Dependent Protein Kinase 1 by Lemercier, Guillaume, Fernandez-Montalvan, Amaury, Shaw, Jeffrey P, Kugelstadt, Dominik, Bomke, Joerg, Domostoj, Mathias, Schwarz, Matthias K, Scheer, Alexander, Kappes, Barbara, Leroy, Didier

“…Malaria remains a major killer in many parts of the world. Recently, there has been an increase in the role of public−private partnerships inciting academic…”
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Export of Plasmodium falciparum calcium‐dependent protein kinase 1 to the parasitophorous vacuole is dependent on three N‐terminal membrane anchor motifs by Möskes, Christian, Burghaus, Petra A., Wernli, Barbara, Sauder, Ursula, Dürrenberger, Markus, Kappes, Barbara

“…Summary Calcium‐dependent protein kinases play a pivotal role in calcium signalling in plants and some protozoa, including the malaria parasites. They are…”
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Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria by Çapcı, Aysun, Lorion, Mélanie M., Wang, Hui, Simon, Nina, Leidenberger, Maria, Borges Silva, Mariana C., Moreira, Diogo R. M., Zhu, Yongping, Meng, Yuqing, Chen, Jia Yun, Lee, Yew Mun, Friedrich, Oliver, Kappes, Barbara, Wang, Jigang, Ackermann, Lutz, Tsogoeva, Svetlana B.

“…A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved…”
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From compound to target: chemical proteomics and in silico screening identify Hsp90 and CDPK2 as putative targets in Plasmodium falciparum by Lauciello, Leonardo, Ahmed, Shaheen, Derrer, Bianca, Kappes, Barbara, Wang, Tai, Seebacher, Werner, Scapozza, Leonardo, Perozzo, Remo

“…Doc number: P60…”
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Quantification of human complement factor H binding to asexual malaria blood stages by an enzyme-linked immunosorbent assay by Simon, Nina, Friedrich, Oliver, Kappes, Barbara

“…[Display omitted] •ELISA validation for quantitative measurement of complement factorH (FH) cell surface binding.•Indirect assessment of stage-specific…”
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Hexacyclinol, a new antiproliferative metabolite of Panus rudis HKI 0254 by Schlegel, Brigitte, Härtl, Albert, Dahse, Hans-Martin, Gollmick, Friedrich A, Gräfe, Udo, Dörfelt, Heinrich, Kappes, Barbara

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Vitamin B6 Biosynthesis by the Malaria Parasite Plasmodium falciparum by Gengenbacher, Martin, Fitzpatrick, Teresa B., Raschle, Thomas, Flicker, Karlheinz, Sinning, Irmgard, Müller, Sylke, Macheroux, Peter, Tews, Ivo, Kappes, Barbara

“…Vitamin B6 is one of nature's most versatile cofactors. Most organisms synthesize vitamin B6 via a recently discovered pathway employing the proteins Pdx1 and…”
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Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities by Reiter, Christoph, Fröhlich, Tony, Gruber, Lisa, Hutterer, Corina, Marschall, Manfred, Voigtländer, Cornelia, Friedrich, Oliver, Kappes, Barbara, Efferth, Thomas, Tsogoeva, Svetlana B.

“…[Display omitted] New pharmaceutically active compounds can be obtained by modification of existing drugs to access more effective agents in the wake of drug…”
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New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids by Reiter, Christoph, Fröhlich, Tony, Zeino, Maen, Marschall, Manfred, Bahsi, Hanife, Leidenberger, Maria, Friedrich, Oliver, Kappes, Barbara, Hampel, Frank, Efferth, Thomas, Tsogoeva, Svetlana B.

“…In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an…”
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Learned sensing: jointly optimized microscope hardware for accurate image classification by Muthumbi, Alex, Chaware, Amey, Kim, Kanghyun, Zhou, Kevin C, Konda, Pavan Chandra, Chen, Richard, Judkewitz, Benjamin, Erdmann, Andreas, Kappes, Barbara, Horstmeyer, Roarke

“…Since its invention, the microscope has been optimized for interpretation by a human observer. With the recent development of deep learning algorithms for…”
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Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities by Karagöz, Aysun Çapcı, Leidenberger, Maria, Hahn, Friedrich, Hampel, Frank, Friedrich, Oliver, Marschall, Manfred, Kappes, Barbara, Tsogoeva, Svetlana B.

“…[Display omitted] Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective…”
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Synthesis of Artemisinin‐Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action by Fröhlich, Tony, Hahn, Friedrich, Belmudes, Lucid, Leidenberger, Maria, Friedrich, Oliver, Kappes, Barbara, Couté, Yohann, Marschall, Manfred, Tsogoeva, Svetlana B.

“…Generation of dimers, trimers and dendrimers of bioactive compounds is an approach that has recently been developed for the discovery of new potent drug…”
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