Search Results - "KANG, Andrew H"

Role of Citrullinated Collagen in Autoimmune Arthritis by Myers, Linda K, Ouyang, Ying-Xin, Patel, Jay R, Odens, Herman H, Woo-Rasberry, Virginia, Park, Jeoungeun, Yi, Ae-Kyung, Rosloniec, Edward F, Brand, David D, Stuart, John M, Kang, Andrew H

“…Citrullination of proteins plays an important role in protein function and it has recently become clear that citrullinated proteins play a role in immune…”
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1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis by Myers, Linda K, Winstead, Michael, Kee, John D, Park, Jeoungeun J, Zhang, Sicheng, Li, Wei, Yi, Ae-Kyung, Stuart, John M, Rosloniec, Edward F, Brand, David D, Tuckey, Robert C, Slominski, Andrzej T, Postlethwaite, Arnold E, Kang, Andrew H

“…Vitamin D plays a crucial role in regulation of the immune response. However, treatment of autoimmune diseases with 1,25-dihydroxyvitamin D3 [1,25(OH) D3]…”
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The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis by Kim, Seunghyun, Easterling, Ellis R, Price, Lauren C, Smith, Savannah L, Coligan, John E, Park, Jeoung-Eun, Brand, David D, Rosloniec, Edward F, Stuart, John M, Kang, Andrew H, Myers, Linda K

“…Several observations implicate a critical role for T cell dysregulation as a central problem in rheumatoid arthritis. We investigated a mechanism for…”
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Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway by Park, Jeoung-Eun, Brand, David D., Rosloniec, Edward F., Yi, Ae-Kyung, Stuart, John M., Kang, Andrew H., Myers, Linda K.

“…Multiple observations implicate T-cell dysregulation as a central event in the pathogenesis of rheumatoid arthritis. Here, we investigated mechanisms for…”
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HLA-DR1 (DRB10101) and DR4 (DRB10401) Use the Same Anchor Residues for Binding an Immunodominant Peptide Derived from Human Type II Collagen by Rosloniec, Edward F, Whittington, Karen B, Zaller, Dennis M, Kang, Andrew H

“…Rheumatoid arthritis is an autoimmune disease in which susceptibility is strongly associated with the expression of specific HLA-DR haplotypes, including DR1…”
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Optimizing oral immune tolerance to Type II collagen in patients with rheumatoid arthritis: The importance of dose, interfering medication and genetics by Postlethwaite, Arnold E., Jiao, Yan, Yang, Chengyuan, Dong, Wei, Aelion, Jacob A., Wang, Benjamin, Postlethwaite, Bennett E., Sigal, Leonard, Kang, Andrew H., Myers, Linda K., Wheller, Patricia, Ingels, Jesse, Gu, Weikuan

“…Oral immune tolerance (OT) is a complex process with unknown genetic regulation. Our aim is to explore possible genetic control of OT in patients with…”
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Effects of a low sodium diet on bone metabolism by CARBONE, Laura D, BARROW, Karen D, BUSH, Andrew J, BOATRIGHT, M. David, MICHELSON, Jean A, PITTS, Kathleen A, PINTEA, Victorina N, KANG, Andrew H, WATSKY, Mitchell A

“…Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study…”
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The relationship of sodium intake to calcium and sodium excretion and bone mineral density of the hip in postmenopausal African-American and Caucasian women by CARBONE, Laura D, BUSH, Andrew J, BARROW, Karen D, KANG, Andrew H

“…During the past several decades in the United States, there has been a shift in dietary habits, with an increased consumption of processed foods that are high…”
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The role of Syk in peripheral T cells by Park, Jeoung-Eun, Majumdar, Sirshendu, Brand, David D., Rosloniec, Edward F., Yi, Ae-Kyung, Stuart, John M., Kang, Andrew H., Myers, Linda K.

“…The aim of this study was to understand how Syk affects peripheral T cell function. T cells from Syk−/− chimeric mice and DR1 Sykfl/fl CD4cre conditional mice…”
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Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide by Park, Jeoung-Eun, Rotondo, Jeffrey A, Cullins, David L, Brand, David D, Yi, Ae-Kyung, Stuart, John M, Kang, Andrew H, Myers, Linda K

“…Rheumatoid arthritis is an autoimmune disorder characterized by T cell dysregulation. We have shown that an altered peptide ligand (A9) activates T cells to…”
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Immunopathogenesis of collagen arthritis by Brand, David D, Kang, Andrew H, Rosloniec, Edward F

“…Collagen-induced arthritis (CIA) is an animal model of autoimmunity that has been studied extensively because of its similarities to rheumatoid arthritis (RA)…”
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Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis by Tang, Bo, Kim, Seunghyun, Hammond, Sarah, Cullins, David L, Brand, David D, Rosloniec, Edward F, Stuart, John M, Postlethwaite, Arnold E, Kang, Andrew H, Myers, Linda K

“…T cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The…”
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Peptide ligand structure and I-Aq binding avidity influence T cell signaling pathway utilization by Myers, Linda K, Cullins, David L, Park, Jeoung-Eun, Yi, Ae-Kyung, Brand, David D, Rosloniec, Edward F, Stuart, John M, Kang, Andrew H

“…Abstract Factors that drive T cells to signal through differing pathways remain unclear. We have shown that an altered peptide ligand (A9) activates T cells to…”
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Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis by Zhou, Bin, Yuan, Jingdong, Zhou, Yixuan, Ghawji, Maher, Deng, Yun-Ping, Lee, Austin J, Lee, Albert J, Nair, Usha, Kang, Andrew H, Brand, David D, Yoo, Tai June

“…Abstract Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1% of the population. Human adipose-derived mesenchymal stem cells…”
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Molecular Basis for T Cell Response Induced by Altered Peptide Ligand of Type II Collagen by Park, Jeoung-Eun, Cullins, David, Zalduondo, Lillian, Barnett, Stacey L., Yi, Ae-Kyung, Kleinau, Sandra, Stuart, John M., Kang, Andrew H., Myers, Linda K.

“…Mounting evidence from animal models has demonstrated that alterations in peptide-MHC interactions with the T cell receptor (TCR) can lead to dramatically…”
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Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis by Kimata, Masaru, Cullins, David L, Brown, Monica L, Brand, David D, Rosloniec, Edward F, Myers, Linda K, Stuart, John M, Kang, Andrew H

“…We used DR1 transgenic mice and covalently linked DR1 multimers to characterize analog-specific inhibitory T cells in collagen-induced arthritis (CIA). Because…”
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Collagen-induced arthritis, an animal model of autoimmunity by Myers, Linda K., Rosloniec, Edward F., Cremer, Michael A., Kang, Andrew H.

“…Collagen induced arthritis (CIA) is an autoimmune model that in many ways resembles rheumatoid arthritis (RA). Immunization of genetically susceptible strains…”
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The mouse model of collagen-induced arthritis by Brand, David D, Kang, Andrew H, Rosloniec, Edward F

“…Collagen-induced arthritis (CIA) is an experimental autoimmune disease that can be elicited in susceptible strains of rodents (rat and mouse) and nonhuman…”
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Genetic and Molecular Basis of Quantitative Trait Loci of Arthritis in Rat: Genes and Polymorphisms by Xiong, Qing, Jiao, Yan, Hasty, Karen A, Stuart, John M, Postlethwaite, Arnold, Kang, Andrew H, Gu, Weikuan

“…Rheumatoid arthritis (RA) is an autoimmune disease, the pathogenesis of which is affected by multiple genetic and environmental factors. To understand the…”
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Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB10101), Complexed with the Immunodominant Determinant of Human Type II Collagen by Rosloniec, Edward F, Ivey, Robert A., III, Whittington, Karen B, Kang, Andrew H, Park, Hee-Won

“…The expression of HLA-DR1 (DRB1*0101) is associated with an enhanced risk for developing rheumatoid arthritis (RA). To study its function, we have solved the…”
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