Search Results - "KANE, Robert R"

Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis by Mattke, Jordan, Darden, Carly M, Lawrence, Michael C, Kuncha, Jayachandra, Shah, Yumna Ali, Kane, Robert R, Naziruddin, Bashoo

“…Acute pancreatitis is a complex inflammatory disease resulting in extreme pain and can result in significant morbidity and mortality. It can be caused by…”
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Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells by Gu, Chao, Upchurch, Katherine, Horton, Joshua, Wiest, Mathew, Zurawski, Sandra, Millard, Mark, Kane, Robert R, Joo, HyeMee, Miller, Lisa A, Oh, SangKon

“…The epithelium-associated cytokine thymic stromal lymphopoietin (TSLP) can induce OX40L and CCL17 expression by myeloid dendritic cells (mDCs), which…”
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Effect of Rubus idaeus L. Consumption During Pregnancy on Maternal Mice and Their Offspring by Hastings-Tolsma, Marie, Stoffel, Ryan T, Quintana, Alexandra S, Kane, Robert R, Turner, Jacob, Wang, Xuan

“…The trigger for human labor is a scientific mystery. This research examined (RI), commonly referred to as red raspberry, which is widely purported to be…”
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Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNα expression by human plasmacytoid dendritic cells by Wiest, Matthew J, Baert, Laurie, Gu, Chao, Gayler, Kevin M, Ham, Hyoungjun, Gorvel, Laurent, Keddis, Mira T, Griffing, Leroy W, Joo, HyeMee, Gorvel, Jean-Pierre, Billadeau, Daniel D, Kane, Robert R, Oh, SangKon

“…Plasmacytoid dendritic cells (pDC) are the major producer of type 1 IFN in response to TLR7 agonists. Aberrant TLR7 activation and type 1 IFN expression by…”
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Inhibition of Toll-like Receptor 4 Using Small Molecule, TAK-242, Protects Islets from Innate Immune Responses by Mattke, Jordan, Darden, Carly M, Vasu, Srividya, Lawrence, Michael C, Kirkland, Jeffrey, Kane, Robert R, Naziruddin, Bashoo

“…Islet transplantation is a therapeutic option to replace β-cell mass lost during type 1 or type 3c diabetes. Innate immune responses, particularly the instant…”
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P.161: Small Molecule Inhibitor of Toll-like Receptor-4, TAK-242, Attenuates Allogenic Immune Responses In Vitro by Mattke, Jordan, Plunk, Michael A., Kane, Robert R., Naziruddin, Bashoo

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Early TLR4 Blockade Attenuates Sterile Inflammation-mediated Stress in Islets During Isolation and Promotes Successful Transplant Outcomes by Chang, Charles A, Murphy, Kayla, Kane, Robert R, Lawrence, Michael C, Naziruddin, Bashoo

“…BACKGROUNDDuring the isolation process, pancreatic islets are exposed to an environment of sterile inflammation resulting in an upregulated inflammatory state…”
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Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation by Chang, Charles A., Akinbobuyi, Babatope, Quintana, Jeremy M., Yoshimatsu, Gumpei, Naziruddin, Bashoo, Kane, Robert R.

“…The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and…”
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Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study by Gayler, Kevin M., Quintana, Jeremy M., Mattke, Jordan, Plunk, Michael A., Kostyo, Jessica H., Karunananthan, Johann W., Nguyen, Harold, Shuda, Mina, Ferreira, Liam D., Baker, Hannah, Stinchcomb, Alexandra L., Sharina, Iraida, Kane, Robert R., Martin, Emil

“…Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A…”
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Design and Catalyzed Activation of Tak-242 Prodrugs for Localized Inhibition of TLR4-Induced Inflammation by Plunk, Michael A, Alaniz, Alyssa, Olademehin, Olatunde P, Ellington, Thomas L, Shuford, Kevin L, Kane, Robert R

“…Tak-242 (resatorvid), a Toll-like Receptor 4 (TLR4) inhibitor, has been identified as a potent suppressor of innate inflammation. As a strategy to target…”
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Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242 by Kostyo, Jessica H., Lallande, Avery T., Sells, Chloë A., Shuda, Mina R., Kane, Robert R.

“…We previously demonstrated that the potent TLR4 inhibitor TAK-242 could be covalently conjugated to pancreatic islets using a linker that afforded an effective…”
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Design and Catalyzed Activation of Mycophenolic Acid Prodrugs by Plunk, Michael A, Quintana, Jeremy M, Darden, Carly M, Lawrence, Michael C, Naziruddin, Bashoo, Kane, Robert R

“…Mycophenolic acid (MPA) and its morpholino ester prodrug mycophenolate mofetil (MMF) are widely used in solid organ transplantation. These drugs prevent…”
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Comparison of surface modification chemistries in mouse, porcine, and human islets by SoRelle, Jeffrey A., Kanak, Mazhar A., Itoh, Takeshi, Horton, Joshua M., Naziruddin, Bashoo, Kane, Robert R.

“…Beta cell replacement therapy, the transplantation of isolated pancreatic islets by intraportal infusion, offers patients with brittle type 1 diabetes blood…”
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Toward a Cancer Therapy with Boron-Rich Oligomeric Phosphate Diesters That Target the Cell Nucleus by Nakanishi, Akira, Guan, Lufeng, Kane, Robert R., Kasamatsu, Harumi, Hawthorne, M. Frederick

“…The viability of boron neutron capture therapy depends on the development of tumor-targeting agents that contain large numbers of boron-10 (10B) atoms and are…”
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Synthesis and immunostimulatory activity of substituted TLR7 agonists by Akinbobuyi, Babatope, Wang, Lei, Upchurch, Katherine C., Byrd, Matthew R., Chang, Charles A., Quintana, Jeremy M., Petersen, Rachel E., Seifert, Zacharie J., Boquin, José R., Oh, SangKon, Kane, Robert R.

“…[Display omitted] Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds,…”
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New TLR7 agonists with improved humoral and cellular immune responses by Upchurch, Katherine C, Boquín, José R, Yin, Wenjie, Xue, Yaming, Joo, HyeMee, Kane, Robert R, Oh, SangKon

“…Highlights • We have developed two new TLR7 agonists, J4 and F4. • They induce phenotype maturation of antigen presenting cells (APCs). • However, they induce…”
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Facile syntheses of functionalized toll-like receptor 7 agonists by Akinbobuyi, Babatope, Byrd, Matthew R., Chang, Charles A., Nguyen, Mysa, Seifert, Zacharie J., Flamar, Anne-Laure, Zurawski, Gerard, Upchurch, Katherine C., Oh, SangKon, Dempsey, Stephen H., Enke, Thomas J., Le, John, Winstead, Hunter J., Boquín, José R., Kane, Robert R.

“…9 new TLR-7 agonists; 10–70% overall for 4–7 steps. X=H, I, CO2H, CN, CONH2, CCCH2OH, CCCH2NH2, (CH2)3NH2, CONHCH2CH2NH2, CONH-PEG2-NH2. [Display omitted]…”
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Efficient Asymmetric Synthesis of the C9−C21 Portion of the Aplysiatoxin and Oscillatoxin Marine Natural Products by Walkup, Robert D, Kahl, Jeffrey D, Kane, Robert R

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Synthesis and photochemical protein crosslinking studies of hydrophilic naphthalimides by JIANXING ZHANG, WOODS, R. Jeremy, BROWN, Philip B, KAP DUK LEE, KANE, Robert R

“…A mixture of 4-alkylamino-1,8-naphthalimides has previously been reported to exhibit potential utility as a photochemical tissue-bonding reagent. In order to…”
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Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis by Sheng, Yezhou, Hua, Jianyi, Pinney, Kevin G., Garner, Charles M., Kane, Robert R., Prezioso, Joseph A., Chaplin, David J., Edvardsen, Klaus

“…The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice…”
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