Search Results - "KANAZU, Takushi"

Cross-species drug metabolism and impact of metabolic stability testing under anaerobic condition on predicting pharmacokinetics of keto-enol containing compound in humans by Kanazu, Takushi, Tamada, Junto, Kume, Susumu, Mizutare, Tohru

“…After oral administration of [14C]-S-1360 in rats and dogs, [14C]-S-1360 was absorbed rapidly and the bioavailability was 93.7% in rats and 75.1% in dogs…”
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Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine by Akazawa, Takanori, Yoshida, Shinpei, Ohnishi, Shuichi, Kanazu, Takushi, Kawai, Makoto, Takahashi, Koji

“…Cell models to investigate intestinal absorption functions, such as those of transporters and metabolic enzymes, are essential for oral drug discovery and…”
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Efficacy of Repeated Intravenous Injection of Peramivir against Influenza A (H1N1) 2009 Virus Infection in Immunosuppressed Mice by KITANO, Mitsutaka, KODAMA, Makoto, ITOH, Yasushi, KANAZU, Takushi, KOBAYASHI, Masanori, YOSHIDA, Ryu, SATO, Akihiko

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques by Kitano, Mitsutaka, Itoh, Yasushi, Kodama, Makoto, Ishigaki, Hirohito, Nakayama, Misako, Ishida, Hideaki, Baba, Kaoru, Noda, Takahiro, Sato, Kenji, Nihashi, Yoichiro, Kanazu, Takushi, Yoshida, Ryu, Torii, Ryuzo, Sato, Akihiko, Ogasawara, Kazumasa

“…We evaluated the efficacy of a single intravenous dose peramivir for treatment of influenza B virus infection in ferrets and cynomolgus macaques in the present…”
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Investigation of drug-drug interaction via mechanism-based inhibition of cytochrome P450 3A by macrolides in dexamethasone-treated female rats by Kanazu, Takushi, Sato, Norihito, Kadono, Kyoko, Touchi, Akira, Takeda, Yuri, Yamaguchi, Yoshitaka, Baba, Takahiko

“…ABSTRACT The in vitro and in vivo inhibition of cytochrome P450 (CYP) 3A with mechanism‐based inhibition (MBI) by macrolides was investigated using…”
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Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action by Sakamoto, Shingo, Kusuhara, Hiroyuki, Miyata, Kenji, Shimaoka, Hiroyuki, Kanazu, Takushi, Matsuo, Yumiko, Nomura, Kohji, Okamura, Noboru, Hara, Seijiro, Horie, Kazutoshi, Baba, Takahiko, Sugiyama, Yuichi

“…Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) is a novel inhibitor of the ileal apical sodium-dependent…”
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Challenges for human metabolite prediction in preclinical by Kanazu, Takushi

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Improved Predictability of Hepatic Clearance with Optimal pH for Acyl-Glucuronidation in Liver Microsomes by Mizutare, Tohru, Sanoh, Seigo, Kanazu, Takushi, Ohta, Shigeru, Kotake, Yaichiro

“…The purpose of this study was to investigate the optimal pH for acyl-glucuronidation formation with carboxylic acid-containing compounds in human and rat liver…”
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Human mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag by Kawachi, Tomoyuki, Ninomiya, Mizuki, Katsube, Takayuki, Wajima, Toshihiro, Kanazu, Takushi

“…The human mass balance of lusutrombopag, an orally bioavailable thrombopoietin (TPO) receptor agonist, was characterised in seven healthy male subjects after a…”
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Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β‑Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial by Koriyama, Yuji, Hori, Akihiro, Ito, Hisanori, Yonezawa, Shuji, Baba, Yoshiyasu, Tanimoto, Norihiko, Ueno, Tatsuhiko, Yamamoto, Shiho, Yamamoto, Takahiko, Asada, Naoya, Morimoto, Kenji, Einaru, Shunsuke, Sakai, Katsunori, Kanazu, Takushi, Matsuda, Akihiro, Yamaguchi, Yoshitaka, Oguma, Takuya, Timmers, Maarten, Tritsmans, Luc, Kusakabe, Ken-ichi, Kato, Akira, Sakaguchi, Gaku

“…Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer’s disease (AD). The aspartyl protease β-site amyloid precursor…”
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Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended‐release tablets by Inoue, Yuji, Morita, Hirotoshi, Nozawa, Kohei, Kanazu, Takushi

“…Guanfacine is used for the treatment of attention‐deficit/hyperactivity disorder (ADHD). Using liquid chromatography–tandem mass spectrometry (LC–MS/MS),…”
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In vitro inhibition and enhancement of liver microsomal S-777469 metabolism by long-chain fatty acids and serum albumin: insight into in vitro and in vivo discrepancy of metabolite formation in humans by Sekiguchi, Kazutaka, Kanazu, Takushi, Murayama, Norie, Yamazaki, Hiroshi, Yamaguchi, Yoshitaka

“…1. It was previously demonstrated that 10% of S-777469, a cannabinoid receptor 2 selective agonist, is metabolized to its carboxylic acid metabolite (S-777469…”
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Comparison of in Vitro Carnitine and Glycine Conjugation with Branched-Side Chain and Cyclic Side Chain Carboxylic Acids in Rats by KANAZU, T, YAMAGUCHI, T

“…The substrate specificity for carnitine conjugation was examined using rat hepatocytes and kidney slices and compared with glycine conjugation which is a…”
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The metabolism and pharmacokinetics of [14C]-S-777469, a new cannabinoid receptor 2 selective agonist, in healthy human subjects by Sekiguchi, Kazutaka, Fukumura, Kazuya, Hasegawa, Hiroshi, Kanazu, Takushi

“…Abstract 1. The metabolism and pharmacokinetics of S-777469 were investigated after a single oral administration of [14C]-S-777469 to healthy human subjects…”
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Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation by Kobayashi, Masanori, Kodama, Makoto, Noshi, Takeshi, Yoshida, Ryu, Kanazu, Takushi, Nomura, Naoki, Soda, Kosuke, Isoda, Norikazu, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Yamano, Yoshinori, Sato, Akihiko, Kida, Hiroshi

“…High morbidity and mortality associated with human cases of highly pathogenic avian influenza (HPAI) viruses, including H5N1 influenza virus, have been…”
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Non-clinical evaluation of the metabolism, pharmacokinetics and excretion of S-777469, a new cannabinoid receptor 2 selective agonist by Sekiguchi, Kazutaka, Kanazu, Takushi, Takeuchi, Masaharu, Hasegawa, Hiroshi, Yamaguchi, Yoshitaka

“…Abstract 1. The drug metabolism and pharmacokinetics of S-777469 were investigated in in vitro (rat, dog and human) and in in vivo (rats and dogs). 2. S-777469…”
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The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice by Kodama, Makoto, Yoshida, Ryu, Hasegawa, Takahiro, Izawa, Masaaki, Kitano, Mitsutaka, Baba, Kaoru, Noshi, Takeshi, Seki, Takahiro, Okazaki, Kenichi, Tsuji, Masakatsu, Kanazu, Takushi, Kamimori, Hiroshi, Homma, Tomoyuki, Kobayashi, Masanori, Sakoda, Yoshihiro, Kida, Hiroshi, Sato, Akihiko, Yamano, Yoshinori

“…•We investigate the relationship between pharmacokinetic parameters and in vivo antiviral activity of peramivir IV.•Peramivir was administrated to mice in…”
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DISTRIBUTION AND EXCRETION OF BORON AFTER INTRAVENOUS ADMINISTRATION OF DISODIUM MERCAPTOUNDECAHYDRO-CLOSO-DODECABORATE TO RATS by YAMAGUCHI, Toshiro, NAKAJIMA, Yoshitsugu, MIYAMOTO, Hiroyuki, MIZOBUCHI, Minoru, KANAZU, Takushi, KADONO, Kyoko, NAKAMOTO, Kayo, IKEUCHI, Isao

“…Disodium mercaptoundecahydro-closo-dodecaborate (BSH) is an important compound for boron neutron capture therapy. The pharmacokinetics of boron by BSH were…”
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Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats by Kanazu, Takushi, Okamura, Noboru, Yamaguchi, Yoshitaka, Baba, Takahiko, Koike, Masahiro

“…In the current study, to understand the characteristics of dexamethasone (DEX)-treated female rats as an animal model for drug-drug interactions, a…”
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DISTRIBUTION AND EXCRETION OF BORON AFTER INTRAVENOUS ADMINISTRATION OF DISODIUM MERCAPTOUNDECAHYDRO-CLOSO-DODECABORATE TO RATS by YAMAGUCHI, Toshiro, NAKAJIMA, Yoshitsugu, MIYAMOTO, Hiroyuki, MIZOBUCHI, Minoru, KANAZU, Takushi, KADONO, Kyoko, NAKAMOTO, Kayo, IKEUCHI, Isao

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