Search Results - "KANASAKI, Megumi"

Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen by KANASAKI, Keizo, SEN SHI, KANASAKI, Megumi, JIANHUA HE, NAGAI, Takako, NAKAMURA, Yuka, ISHIGAKI, Yasuhito, KITADA, Munehiro, SWAYAM PRAKASH SRIVASTAVA, KOYA, Daisuke

“…Kidney fibrosis is the final common pathway of all progressive chronic kidney diseases, of which diabetic nephropathy is the leading cause…”
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Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition by Shi, Sen, Srivastava, Swayam Prakash, Kanasaki, Megumi, He, Jianhua, Kitada, Munehiro, Nagai, Takako, Nitta, Kyoko, Takagi, Susumu, Kanasaki, Keizo, Koya, Daisuke

“…Integrin β1 and dipeptidyl peptidase (DPP)-4 play roles in endothelial cell biology. Vascular endothelial growth factor (VEGF)-A inhibits…”
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Association between subjective walking speed and metabolic diseases in individuals with obesity: a cross-sectional analysis by Yamamoto, Yuiko, Ikeue, Kentaro, Kanasaki, Megumi, Yamakage, Hajime, Oishi, Kan, Mori, Takaaki, Satoh-Asahara, Noriko, Masuda, Izuru, Ishii, Kojiro

“…The association between subjective walking speed and metabolic diseases has received limited attention, particularly in individuals with obesity. We aimed to…”
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Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II by Ueki, Norikazu, Kanasaki, Keizo, Kanasaki, Megumi, Takeda, Satoru, Koya, Daisuke

“…Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension…”
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Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice by Parchem, Jacqueline G, Kanasaki, Keizo, Kanasaki, Megumi, Sugimoto, Hikaru, Xie, Liang, Hamano, Yuki, Lee, Soo Bong, Gattone, Vincent H, Parry, Samuel, Strauss, Jerome F, Garovic, Vesna D, McElrath, Thomas F, Lu, Karen H, Sibai, Baha M, LeBleu, Valerie S, Carmeliet, Peter, Kalluri, Raghu

“…Preeclampsia remains a clinical challenge due to its poorly understood pathogenesis. A prevailing notion is that increased placental production of soluble…”
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Effect of Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related Kidney Fibrosis by Srivastava, Swayam Prakash, Shi, Sen, Kanasaki, Megumi, Nagai, Takako, Kitada, Munehiro, He, Jianhua, Nakamura, Yuka, Ishigaki, Yasuhito, Kanasaki, Keizo, Koya, Daisuke

“…N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous antifibrotic peptide. We found that suppression of AcSDKP and induction of dipeptidyl…”
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N-acetyl-seryl-aspartyl-lysyl-proline Inhibits Diabetes-Associated Kidney Fibrosis and Endothelial-Mesenchymal Transition by Nagai, Takako, Kanasaki, Megumi, Srivastava, Swayam Prakash, Nakamura, Yuka, Ishigaki, Yasuhito, Kitada, Munehiro, Shi, Sen, Kanasaki, Keizo, Koya, Daisuke

“…Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth…”
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Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice by Kanasaki, Megumi, Srivastava, Swayam Prakash, Yang, Fan, Xu, Ling, Kudoh, Sumiyo, Kitada, Munehiro, Ueki, Norikazu, Kim, Hyoh, Li, Jinpeng, Takeda, Satoru, Kanasaki, Keizo, Koya, Daisuke

“…2-methoxyestradiol (2-ME), an estrogen metabolite generated via catechol-o-methyltransferase (COMT), is multifunctional methoxy-catechol. Here, we report that…”
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A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus by Li, Jinpeng, Kanasaki, Megumi, Xu, Ling, Kitada, Munehiro, Nagao, Kenji, Adachi, Yusuke, Jinzu, Hiroko, Noguchi, Yasushi, Kohno, Miyuki, Kanasaki, Keizo, Koya, Daisuke

“…Muscle biology is important topic in diabetes research. We have reported that a diet with ketogenic amino acids rich replacement (KAAR) ameliorated high-fat…”
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Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen by Koya, Daisuke, Kanasaki, Keizo, Srivastava, Swayam Prakash, Kitada, Munehiro, Kanasaki, Megumi, Nagai, Takako, Shi, Sen, Nitta, Kyoko, Haneda, Masakazu

“…Kidney fibrosis is the final common pathway of progressive kidney diseases including diabetic nephropathy. Here, we report that the endogenous antifibrotic…”
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Loss of p53 and Acquisition of Angiogenic MicroRNA Profile Are Insufficient to Facilitate Progression of Bladder Urothelial Carcinoma in Situ to Invasive Carcinoma by Ayala de la Peña, Francisco, Kanasaki, Keizo, Kanasaki, Megumi, Tangirala, Neelima, Maeda, Genta, Kalluri, Raghu

“…Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer. Here we report cloning…”
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Age‐wise examination of the association of obesity based on body mass index and waist circumference with metabolic diseases in comprehensive health checkup participants by Yamamoto, Yuiko, Ikeue, Kentaro, Kanasaki, Megumi, Yamakage, Hajime, Satoh‐Asahara, Noriko, Masuda, Izuru, Ishii, Kojiro

“…Aim Body mass index and waist circumference are used for obesity diagnosis and screening of visceral fat; however, their evidence in older adults is…”
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Loss of β1‐integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype by Kanasaki, Keizo, Yu, Weiqun, Bodungen, Maximilian, Larigakis, John D., Kanasaki, Megumi, Pena, Francisco Ayala, Kalluri, Raghu, Hill, Warren G.

“…Bladder urothelium senses and communicates information about bladder fullness. However, the mechanoreceptors that respond to tissue stretch are poorly defined…”
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The biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis by Nagai, Takako, Nitta, Kyoko, Kanasaki, Megumi, Koya, Daisuke, Kanasaki, Keizo

“…Both angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin II receptor blocker have been recognized as renin–angiotensin system (RAS) inhibitors…”
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STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects by Parchem, Jacqueline G, Kanasaki, Keizo, Lee, Soo Bong, Kanasaki, Megumi, Yang, Joyce L, Xu, Yong, Earl, Kadeshia M, Keuls, Rachel A, Gattone, 2nd, Vincent H, Kalluri, Raghu

“…The pathogenesis of preeclampsia and other hypertensive disorders of pregnancy remains poorly defined despite the substantial burden of maternal and neonatal…”
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Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia by Tsuda, Shin-ichi, Konishi, Kazunori, Otoda, Toshiki, Nagai, Takako, Takeda-Watanabe, Ai, Kanasaki, Megumi, Kitada, Munehiro, Nakagawa, Atsushi, Nishizawa, Makoto, Kanasaki, Keizo, Koya, Daisuke

“…An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The…”
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Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects by Ayala de la Peña, Francisco, Kanasaki, Keizo, Kanasaki, Megumi, Vong, Sylvia, Rovira, Carlota, Kalluri, Raghu

“…K-ras is essential for embryogenesis and its mutations are involved in human developmental syndromes and cancer. To determine the consequences of K-ras…”
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Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors by Kanasaki, Megumi, Nagai, Takako, Kitada, Munehiro, Koya, Daisuke, Kanasaki, Keizo

“…Blockade of the renin-angiotensin system (RAS) is well recognized as an essential therapy in hypertensive, heart, and kidney diseases. There are several…”
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Phase Angle Predicts Mild Cognitive Impairment In Female Health Screening Participants; Elder-safe Study Kyoto: 338 by Ikeue, Kentaro, Yamakage, Hajime, Kato, Sayaka, Kato, Hisashi, Oishi, Kan, Yamamoto, Yuiko, Kanasaki, Megumi, Masuda, Izuru, Ishii, Kojiro, Satoh-Asahara, Noriko

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Association of age with computed tomography airway tree morphology in male and female never smokers without lung disease history by Terada, Satoru, Tanabe, Naoya, Maetani, Tomoki, Shiraishi, Yusuke, Sakamoto, Ryo, Shima, Hiroshi, Oguma, Tsuyoshi, Sato, Atsuyasu, Kanasaki, Megumi, Masuda, Izuru, Sato, Susumu, Hirai, Toyohiro

“…Sex and aging may affect the airway tree structure in patients with airway diseases and even healthy subjects. Using chest computed tomography (CT), this study…”
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