Search Results - "KANAMARU, R"

Functional Evaluation of p53 and PTEN Gene Mutations in Gliomas by KATO, Hideaki, KATO, Shunsuke, ISHIOKA, Chikashi, KUMABE, Toshihiro, SONODA, Yukihiko, YOSHIMOTO, Takashi, KATO, Satoshi, HAN, Shuang-Yin, SUZUKI, Takao, SHIBATA, Hiroyuki, KANAMARU, Ryunosuke

“…We screened mutations of two major tumor suppressor genes, p53 and PTEN , in 66 human brain tumors using a yeast-based functional assay and cDNA-based direct…”
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Cancer diagnosis using microarray technologies by Kanamaru, R

“…Recently, functional genomics has developed through the use of using microarray technologies. These microarray technologies enable us to analyze the expression…”
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Advances in cancer research. Cancer research and clinical oncology in the 21st century by Kanamaru, R

“…It is my great pleasure to congradulate the Japanese Journal of Cancer and Chemotherapy on its 25 th anniversary. During this period, great progress has been…”
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Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer by Sakayori, M., Kawahara, M., Shiraishi, K., Nomizu, T., Shimada, A., Kudo, T., Abe, R., Ohuchi, N., Takenoshita, S., Kanamaru, R., Ishioka, C.

“…Screening for protein-truncating mutations of the BRCA1 and BRCA2 genes is useful in genetic testing for familial breast cancer because, first, the methods are…”
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Late phase II clinical study of RP56976 (docetaxel) in patients with advanced/recurrent gastric cancer: a Japanese Cooperative Study Group trial (group A) by Taguchi, T, Sakata, Y, Kanamaru, R, Kurihara, M, Suminaga, M, Ota, J, Hirabayashi, N

“…A late phase II clinical study of RP56976 (docetaxel) was conducted in patients with advanced/recurrent gastric cancer as a multicenter cooperative trial…”
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A late phase II clinical study of RP56976 (docetaxel) in patients with advanced or recurrent gastric cancer: a cooperative study group trial (group B) by Mai, M, Sakata, Y, Kanamaru, R, Kurihara, M, Suminaga, M, Ota, J, Hirabayashi, N, Taguchi, T, Furue, H

“…A late phase II clinical study of RP56976 (docetaxel) in patients with advanced or recurrent gastric cancer was performed to evaluate the anti-tumor activity…”
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Understanding the Function-Structure and Function-Mutation Relationships of p53 Tumor Suppressor Protein by High-Resolution Missense Mutation Analysis by Kato, Shunsuke, Han, Shuang-Yin, Liu, Wen, Otsuka, Kazunori, Shibata, Hiroyuki, Kanamaru, Ryunosuke, Ishioka, Chikashi

“…Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic alteration in human cancers. The common missense mutations in the…”
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Genetic background in carcinogenesis by Suzuki, T, Kanamaru, R

“…Carcinogenesis comprises both genetic and environmental factors. The genetic factor for cancer is most closely associated with familial cancer. Familial cancer…”
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Enhancement of chemotherapeutic effects with focused shock waves: extracorporeal shock wave chemotherapy (ESWC) by Kambe, M, Ioritani, N, Kanamaru, R

“…The effects of shock waves in combination with various anti-cancer agents i.e. Bleomycin(BLM), Cis-platinum (CDDP) and 5-fluorouracil(5-FU) on various human…”
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Phase I studies of nogitecan hydrochloride for Japanese by Kobayashi, Kunihiko, Hino, Mitsunori, Fukuoka, Masahiro, Takeuchi, Kunio, Furuse, Kiyoyuki, Yoneda, Shuichi, Hasegawa, Koichi, Noda, Kiichiro, Kinoshita, Hiroaki, Kimura, Ikuro, Taguchi, Tetsuo, Kanamaru, Ryunosuke, Horikoshi, Noboru, Niitani, Hisanobu

“…SmithKline Beecham synthesized camptothecin analogs and identified nogitecan hydrochloride (topotecan) with a broad spectrum of antitumor activity and less…”
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Phase I clinical trial of RP 56976 (docetaxel) a new anticancer drug by Taguchi, T, Furue, H, Niitani, H, Ishitani, K, Kanamaru, R, Hasegawa, K, Ariyoshi, Y, Noda, K, Furuse, K, Fukuoka, M

“…A multicenter phase I clinical trial of RP 56976 (docetaxel), a new anticancer drug, was performed with single and repeated doses. Based on the results of…”
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Accumulation of 2-Deoxy-2[18F]Fluoro-D-Glucose in Human Cancers Heterotransplanted in Nude Mice: Comparison Between Histology and Glycolytic Status by Yoshioka, Takashi, Takahashi, Hiromu, Oikawa, Hirosuke, Maeda, Syunichi, Wakui, Akira, Watanabe, Tadashi, Tezuka, Fumiaki, Takahashi, Tohru, Ido, Tatuo, Kanamaru, Ryunosuke

“…The success of tumor imaging with PET and 2-deoxy-2-fluoro[18F]-D-glucose (18FDG) is based on preferential accumulation of 18FDG in tumors. Fluorine-18-FDG…”
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Astrocytoma and B-cell lymphoma development in a man with a p53 germline mutation by Murakawa, Y, Yokoyama, A, Kato, S, Yoshioka, T, Ichinohasama, R, Kumabe, T, Yoshimoto, T, Ishioka, C, Kanamaru, R

“…We report a case with a germline mutation of the p53 gene develpoing both a non-Hodgkin's lymphoma and an astrocytoma. The astrocytoma could be cured by two…”
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Enhancement of chemotherapeutic effects with focused shock waves: extracorporeal shock wave chemotherapy (ESWC) by Kambe, M, Ioritani, N, Shirai, S, Kambe, K, Kuwahara, M, Arita, D, Funato, T, Shimodaira, H, Gamo, M, Orikasa, S, Kanamaru, R

“…The effects of shock waves in combination with various anti-cancer agents i.e. Bleomycin (BLM), Cisplatin (CDDP) and 5-fluorouracil (5-FU) on tumor cells…”
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Cloning and functional analysis of human p51 , which structurally and functionally resembles p53 by Osada, Motonobu, Ohba, Mai, Kawahara, Chikashi, Ishioka, Chikashi, Kanamaru, Ryunosuke, Katoh, Iyoko, Ikawa, Yoji, Nimura, Yoshinori, Nakagawara, Akira, Obinata, Masuo, Ikawa, Shuntaro

“…The p53 tumor suppressor gene, which is induced by DNA damage and/or stress stimuli, causes cells to undergo G1-arrest or apoptotic death; thus it plays an…”
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p53 as a molecular target for cancer therapy by Ishioka, C, Osada, M, Gamo, M, Kanamaru, R

“…Development of novel strategies is required for cancer treatment because most human tumors are refractory to current conventional therapy. During the past…”
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Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene by Shibata, Hiroyuki, Toyama, Kaoru, Shioya, Hisashi, Ito, Masaki, Hirota, Morihisa, Hasegawa, Sumitaka, Matsumoto, Hiroshi, Takano, Hiroshi, Akiyama, Tetsu, Toyoshima, Kumao, Kanamaru, Ryunosuke, Kanegae, Yumi, Saito, Izumu, Nakamura, Yusuke, Shiba, Kiyotaka, Noda, Tetsuo

“…Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry…”
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Modification of gene targeting method for functional analysis of the target gene in vivo by Shibata, H, Kanamaru, R, Noda, T

“…Gene targeting in ES cells is a powerful tool to generate mice bearing predesigned mutations in the germ line. However, these mice carrying such constitutional…”
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Effect of a new anticancer drug, docetaxel (RP56976), on human leukemia cell lines by Murata, K, Sato, T, Kanamaru, R

“…The antitumor effect of a new derivative of taxol, docetaxel (RP56976), was examined in K562 human tumor system in vitro. K562 cells presenting a multidrug…”
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A lipophilic derivative of neocarzinostatin. A polymer conjugation of an antitumor protein antibiotic by Maeda, H, Takeshita, J, Kanamaru, R

“…A lipophilic derivative of neocarzinostatin (NCS), an antitumor antibiotic, was prepared by reaction with a synthetic water-soluble polymer, [(styrene)1…”
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