Search Results - "KANAI, AKINORI"

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation by Nagase, Reina, Inoue, Daichi, Pastore, Alessandro, Fujino, Takeshi, Hou, Hsin-An, Yamasaki, Norimasa, Goyama, Susumu, Saika, Makoto, Kanai, Akinori, Sera, Yasuyuki, Horikawa, Sayuri, Ota, Yasunori, Asada, Shuhei, Hayashi, Yasutaka, Kawabata, Kimihito Cojin, Takeda, Reina, Tien, Hwei-Fang, Honda, Hiroaki, Abdel-Wahab, Omar, Kitamura, Toshio

“…( ) is frequently mutated in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP). Although loss of ASXL1 promotes hematopoietic…”
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Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA by Misawa, Kiyoshi, Imai, Atsushi, Matsui, Hirotaka, Kanai, Akinori, Misawa, Yuki, Mochizuki, Daiki, Mima, Masato, Yamada, Satoshi, Kurokawa, Tomoya, Nakagawa, Takuya, Mineta, Hiroyuki

“…Human papilloma virus (HPV)-associated oropharyngeal cancer (OPC) is an independent tumour type with regard to cellular, biological, and clinical features. The…”
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Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction by Suzuki, Nanoka, Kanai, Akinori, Suzuki, Yutaka, Ogino, Hajime, Ochi, Haruki

“…Despite the recent discovery of tissue regeneration enhancers in highly regenerative animals, upstream and downstream genetic programs connected by these…”
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MOZ/ENL complex is a recruiting factor of leukemic AF10 fusion proteins by Komata, Yosuke, Kanai, Akinori, Maeda, Takahiro, Inaba, Toshiya, Yokoyama, Akihiko

“…Changes in the transcriptional machinery cause aberrant self-renewal of non-stem hematopoietic progenitors. AF10 fusions, such as CALM-AF10, are generated via…”
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Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation by Bai, Jie, Yokomizo-Nakano, Takako, Kubota, Sho, Sun, Yuqi, Kanai, Akinori, Iimori, Mihoko, Harada, Hironori, Iwama, Atsushi, Sashida, Goro

“…High Mobility Group AT-hook 2 (HMGA2) is a chromatin modifier and its overexpression has been found in patients with myelodysplastic syndrome (MDS) and acute…”
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Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm by Kubota, Sho, Tokunaga, Kenji, Umezu, Tomohiro, Yokomizo-Nakano, Takako, Sun, Yuqi, Oshima, Motohiko, Tan, Kar Tong, Yang, Henry, Kanai, Akinori, Iwanaga, Eisaku, Asou, Norio, Maeda, Takahiro, Nakagata, Naomi, Iwama, Atsushi, Ohyashiki, Kazuma, Osato, Motomi, Sashida, Goro

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute leukemia, the cell of origin of which is considered to be precursors of…”
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Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells by Zhou, Guanyu, Shimura, Tsutomu, Yoneima, Taiki, Nagamachi, Akiko, Kanai, Akinori, Doi, Kazutaka, Sasatani, Megumi

“…Age at exposure is a critical modifier of the risk of radiation-induced cancer. However, the effects of age on radiation-induced carcinogenesis remain poorly…”
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The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition by Sashida, Goro, Wang, Changshan, Tomioka, Takahisa, Oshima, Motohiko, Aoyama, Kazumasa, Kanai, Akinori, Mochizuki-Kashio, Makiko, Harada, Hironori, Shimoda, Kazuya, Iwama, Atsushi

“…EZH2 is a component of polycomb repressive complex 2 (PRC2) and functions as an H3K27 methyltransferase. Loss-of-function mutations in EZH2 are associated with…”
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Ribosome profiling analysis reveals the roles of DDX41 in translational regulation by Tungalag, Saruul, Shinriki, Satoru, Hirayama, Mayumi, Nagamachi, Akiko, Kanai, Akinori, Inaba, Toshiya, Matsui, Hirotaka

“…DDX41 mutation has been observed in myeloid malignancies including myelodysplastic syndromes and acute myeloid leukemia, but the underlying causative…”
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HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways by Miyamoto, Ryo, Kanai, Akinori, Okuda, Hiroshi, Komata, Yosuke, Takahashi, Satoshi, Matsui, Hirotaka, Inaba, Toshiya, Yokoyama, Akihiko

“…HOXA9 is often highly expressed in leukemias. However, its precise roles in leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression…”
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GLIS1, a novel hypoxia-inducible transcription factor, promotes breast cancer cell motility via activation of WNT5A by Shimamoto, Kazumi, Tanimoto, Keiji, Fukazawa, Takahiro, Nakamura, Hideaki, Kanai, Akinori, Bono, Hidemasa, Ono, Hiromasa, Eguchi, Hidetaka, Hirohashi, Nobuyuki

“…Abstract We previously demonstrated that expression of a Krüppel-like zinc finger transcription factor, GLIS1, dramatically increases under hypoxic conditions…”
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Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia by Miyamoto, Ryo, Okuda, Hiroshi, Kanai, Akinori, Takahashi, Satoshi, Kawamura, Takeshi, Matsui, Hirotaka, Kitamura, Toshio, Kitabayashi, Issay, Inaba, Toshiya, Yokoyama, Akihiko

“…Uncontrolled self-renewal of hematopoietic progenitors induces leukemia. To self-renew, leukemia cells must continuously activate genes that were previously…”
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Phasing analysis of lung cancer genomes using a long read sequencer by Sakamoto, Yoshitaka, Miyake, Shuhei, Oka, Miho, Kanai, Akinori, Kawai, Yosuke, Nagasawa, Satoi, Shiraishi, Yuichi, Tokunaga, Katsushi, Kohno, Takashi, Seki, Masahide, Suzuki, Yutaka, Suzuki, Ayako

“…Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20…”
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AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription by Okuda, Hiroshi, Kanai, Akinori, Ito, Shinji, Matsui, Hirotaka, Yokoyama, Akihiko

“…Gene rearrangements generate MLL fusion genes, which can lead to aggressive leukemia. In most cases, MLL fuses with a gene encoding a component of the AEP (AF4…”
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Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells by Nagamachi, Akiko, Kikuchi, Jiro, Kanai, Akinori, Furukawa, Yusuke, Inaba, Toshiya

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Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs by Yokomizo-Nakano, Takako, Hamashima, Ai, Kubota, Sho, Bai, Jie, Sorin, Supannika, Sun, Yuqi, Kikuchi, Kenta, Iimori, Mihoko, Morii, Mariko, Kanai, Akinori, Iwama, Atsushi, Huang, Gang, Kurotaki, Daisuke, Takizawa, Hitoshi, Matsui, Hirotaka, Sashida, Goro

“…Aberrant innate immune signaling in myelodysplastic syndrome (MDS) hematopoietic stem/progenitor cells (HSPCs) has been implicated as a driver of the…”
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Detection of Pretreatment Circulating Tumor DNA Predicts Recurrence after High-Dose Proton Beam Therapy for Early-Stage Non-Small Cell Lung Cancer by Nakamura, Masaki, Kageyama, Shun-Ichiro, Hirata, Hidenari, Tochinai, Taku, Hojo, Hidehiro, Motegi, Atsushi, Kanai, Akinori, Suzuki, Yutaka, Tsuchihara, Katsuya, Akimoto, Tetsuo

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DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells by Shinriki, Satoru, Hirayama, Mayumi, Nagamachi, Akiko, Yokoyama, Akihiko, Kawamura, Takeshi, Kanai, Akinori, Kawai, Hidehiko, Iwakiri, Junichi, Liu, Rin, Maeshiro, Manabu, Tungalag, Saruul, Tasaki, Masayoshi, Ueda, Mitsuharu, Tomizawa, Kazuhito, Kataoka, Naoyuki, Ideue, Takashi, Suzuki, Yutaka, Asai, Kiyoshi, Tani, Tokio, Inaba, Toshiya, Matsui, Hirotaka

“…Myeloid malignancies with DDX41 mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the…”
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Intense Expression of EGFR L858R Characterizes the Micropapillary Component and L858R Is Associated with the Risk of Recurrence in pN0M0 Lung Adenocarcinoma with the Micropapillary Component by Kishi, Naoto, Ito, Masaoki, Miyata, Yoshihiro, Kanai, Akinori, Handa, Yoshinori, Tsutani, Yasuhiro, Kushitani, Kei, Takeshima, Yukio, Okada, Morihito

“…Background Lung adenocarcinoma with the micropapillary (MP) component poses a higher risk of recurrence even when the MP component is not predominant. This…”
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HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis by Takahashi, Satoshi, Kanai, Akinori, Okuda, Hiroshi, Miyamoto, Ryo, Komata, Yosuke, Kawamura, Takeshi, Matsui, Hirotaka, Inaba, Toshiya, Takaori-Kondo, Akifumi, Yokoyama, Akihiko

“…Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the…”
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