Search Results - "KANAAN, M"

Liquid-liquid phase separation induces pathogenic tau conformations in vitro by Kanaan, Nicholas M., Hamel, Chelsey, Grabinski, Tessa, Combs, Benjamin

“…Formation of membrane-less organelles via liquid-liquid phase separation is one way cells meet the biological requirement for spatiotemporal regulation of…”
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Aging and Parkinson's disease: Different sides of the same coin? by Collier, Timothy J., Kanaan, Nicholas M., Kordower, Jeffrey H.

“…ABSTRACT Despite abundant epidemiological evidence in support of aging as the primary risk factor for PD, biological correlates of a connection have been…”
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Pathological conformations involving the amino terminus of tau occur early in Alzheimer’s disease and are differentially detected by monoclonal antibodies by Combs, Benjamin, Hamel, Chelsey, Kanaan, Nicholas M

“…Abstract Conformational changes involving the amino-terminus of the tau protein are among the earliest alterations associated with tau pathology in Alzheimer’s…”
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Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey by Kanaan, Nicholas M, Grabinski, Tessa

“…Tau is a microtubule-associated protein for which the physiological functions remain a topic of vigorous investigation. Additionally, tau is a central player…”
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Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo by Apicco, Daniel J., Ash, Peter E. A., Maziuk, Brandon, LeBlang, Chelsey, Medalla, Maria, Al Abdullatif, Ali, Ferragud, Antonio, Botelho, Emily, Ballance, Heather I., Dhawan, Uma, Boudeau, Samantha, Cruz, Anna Lourdes, Kashy, Daniel, Wong, Aria, Goldberg, Lisa R., Yazdani, Neema, Zhang, Cheng, Ung, Choong Y., Tripodis, Yorghos, Kanaan, Nicholas M., Ikezu, Tsuneya, Cottone, Pietro, Leszyk, John, Li, Hu, Luebke, Jennifer, Bryant, Camron D., Wolozin, Benjamin

“…Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular…”
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Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms by Kneynsberg, Andrew, Combs, Benjamin, Christensen, Kyle, Morfini, Gerardo, Kanaan, Nicholas M

“…Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with…”
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A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures by Grabinski, Tessa M, Kneynsberg, Andrew, Manfredsson, Fredric P, Kanaan, Nicholas M

“…In situ hybridization (ISH) is an extremely useful tool for localizing gene expression and changes in expression to specific cell populations in tissue samples…”
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Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases by Kanaan, Nicholas M, Morfini, Gerardo A, LaPointe, Nichole E, Pigino, Gustavo F, Patterson, Kristina R, Song, Yuyu, Andreadis, Athena, Fu, Yifan, Brady, Scott T, Binder, Lester I

“…Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer's disease (AD) and…”
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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration by Paumier, Katrina L, Luk, Kelvin C, Manfredsson, Fredric P, Kanaan, Nicholas M, Lipton, Jack W, Collier, Timothy J, Steece-Collier, Kathy, Kemp, Christopher J, Celano, Stephanie, Schulz, Emily, Sandoval, Ivette M, Fleming, Sheila, Dirr, Elliott, Polinski, Nicole K, Trojanowski, John Q, Lee, Virginia M, Sortwell, Caryl E

“…Abstract Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn) into mice induce Parkinson's disease (PD)-like Lewy…”
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Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease by Patterson, Kristina R., Remmers, Christine, Fu, Yifan, Brooker, Sarah, Kanaan, Nicholas M., Vana, Laurel, Ward, Sarah, Reyes, Juan F., Philibert, Keith, Glucksman, Marc J., Binder, Lester I.

“…Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and…”
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Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy by Ono, Maiko, Komatsu, Masaaki, Ji, Bin, Takado, Yuhei, Shimojo, Masafumi, Minamihisamatsu, Takeharu, Warabi, Eiji, Yanagawa, Toru, Matsumoto, Gen, Aoki, Ichio, Kanaan, Nicholas M., Suhara, Tetsuya, Sahara, Naruhiko, Higuchi, Makoto

“…Intracellular accumulation of filamentous tau aggregates with progressive neuronal loss is a common characteristic of tauopathies. Although the…”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E

“…Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a platform to…”
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Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory by Fá, M., Puzzo, D., Piacentini, R., Staniszewski, A., Zhang, H., Baltrons, M. A., Li Puma, D. D., Chatterjee, I., Li, J., Saeed, F., Berman, H. L., Ripoli, C., Gulisano, W., Gonzalez, J., Tian, H., Costa, J. A., Lopez, P., Davidowitz, E., Yu, W. H., Haroutunian, V., Brown, L. M., Palmeri, A., Sigurdsson, E. M., Duff, K. E., Teich, A. F., Honig, L. S., Sierks, M., Moe, J. G., D’Adamio, L., Grassi, C., Kanaan, N. M., Fraser, P. E., Arancio, O.

“…Non-fibrillar soluble oligomeric forms of amyloid-β peptide (oAβ) and tau proteins are likely to play a major role in Alzheimer’s disease (AD). The prevailing…”
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils by Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.

“…Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration of the nigrostriatal system…”
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Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy by Kanaan, Nicholas M., Cox, Kristine, Alvarez, Victor E., Stein, Thor D., Poncil, Sharra, McKee, Ann C.

“…Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that develops after repetitive head injury. Several lines of evidence in other…”
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Acupuncture in practice: mapping the providers, the patients and the settings in a national cross-sectional survey by Hopton, A K, Curnoe, S, Kanaan, M, MacPherson, H

“…BackgroundThere is relatively limited knowledge about the practitioners who provide acupuncture treatment within the UK, what conditions patients consult for…”
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Axonal Transport Defects in Neurodegenerative Diseases by Morfini, Gerardo A, Burns, Matthew, Binder, Lester I, Kanaan, Nicholas M, LaPointe, Nichole, Bosco, Daryl A, Brown, Robert H., Jr, Brown, Hannah, Tiwari, Ashutosh, Hayward, Lawrence, Edgar, Julia, Nave, Klaus-Armin, Garberrn, James, Atagi, Yuka, Song, Yuyu, Pigino, Gustavo, Brady, Scott T

“…Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of neurological disorders characterized by a progressive, age-dependent decline…”
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EFhd2 Affects Tau Liquid-Liquid Phase Separation by Vega, Irving E, Umstead, Andrew, Kanaan, Nicholas M

“…The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer's disease and related…”
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Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition by Cox, Kristine, Combs, Benjamin, Abdelmesih, Brenda, Morfini, Gerardo, Brady, Scott T, Kanaan, Nicholas M

“…Abstract Misfolded tau proteins are characteristic of tauopathies, but the isoform composition of tau inclusions varies by tauopathy. Using aggregates of the…”
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Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization by Shirafuji, Norimichi, Hamano, Tadanori, Yen, Shu-Hui, Kanaan, Nicholas M, Yoshida, Hirotaka, Hayashi, Kouji, Ikawa, Masamichi, Yamamura, Osamu, Kuriyama, Masaru, Nakamoto, Yasunari

“…Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason…”
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