Search Results - "KAMRADT, Thomas"

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction by Wehmeyer, Corinna, Frank, Svetlana, Beckmann, Denise, Böttcher, Martin, Cromme, Christoph, König, Ulrich, Fennen, Michelle, Held, Annelena, Paruzel, Peter, Hartmann, Christine, Stratis, Athanasios, Korb-Pap, Adelheid, Kamradt, Thomas, Kramer, Ina, van den Berg, Wim, Kneissel, Michaela, Pap, Thomas, Dankbar, Berno

“…Sclerostin, an inhibitor of the Wnt/β-catenin pathway, has anti-anabolic effects on bone formation by negatively regulating osteoblast differentiation…”
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The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 by Brustle, Anne, Heink, Sylvia, Huber, Magdalena, Rosenplanter, Christine, Stadelmann, Christine, Yu, Philipp, Arpaia, Enrico, Mak, Tak W, Kamradt, Thomas, Lohoff, Michael

“…Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of…”
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IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells by Kulkarni, Upasana, Herrmenau, Christoph, Win, Stephanie J, Bauer, Michael, Kamradt, Thomas

“…Immunological dysregulation in sepsis is associated with often lethal secondary infections. Loss of effector cells and an expansion of immunoregulatory cell…”
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Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort by Andreas, Nico, Geißler, Katharina, Priese, Juliane, Guntinas-Lichius, Orlando, Kamradt, Thomas

“…Although tonsillectomy is performed frequently, the role of palatine tonsils in life long immune protection or tolerance is still debated and the consequences…”
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ATP/IL‐33‐triggered hyperactivation of mast cells results in an amplified production of pro‐inflammatory cytokines and eicosanoids by Jordan, Paul M., Andreas, Nico, Groth, Marco, Wegner, Philine, Weber, Franziska, Jäger, Ute, Küchler, Claudia, Werz, Oliver, Serfling, Edgar, Kamradt, Thomas, Dudeck, Anne, Drube, Sebastian

“…IL‐33 and ATP are alarmins, which are released upon damage of cellular barriers or are actively secreted upon cell stress. Due to high‐density expression of…”
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Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma by Boehne, Carolin, Behrendt, Ann-Kathrin, Meyer-Bahlburg, Almut, Boettcher, Martin, Drube, Sebastian, Kamradt, Thomas, Hansen, Gesine

“…T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) has been described as a transmembrane protein, expressed on the surface of various T cells…”
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Vacuolar (H + )-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation by Rao, Zhigang, Pace, Simona, Jordan, Paul M, Bilancia, Rossella, Troisi, Fabiana, Börner, Friedemann, Andreas, Nico, Kamradt, Thomas, Menche, Dirk, Rossi, Antonietta, Serhan, Charles N, Gerstmeier, Jana, Werz, Oliver

“…Alternative (M2)-polarized macrophages possess high capacities to produce specialized proresolving mediators (SPM; i.e., resolvins, protectins, and maresins)…”
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What Are the Peripheral Blood Determinants for Increased Osteoclast Formation in the Various Inflammatory Diseases Associated With Bone Loss? by de Vries, Teun J, El Bakkali, Ismail, Kamradt, Thomas, Schett, Georg, Jansen, Ineke D C, D'Amelio, Patrizia

“…Local priming of osteoclast precursors (OCp) has long been considered the main and obvious pathway that takes place in the human body, where local bone lining…”
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Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity by Kim, Kyung Mok, Mura-Meszaros, Anna, Tollot, Marie, Krishnan, Murali Shyam, Gründl, Marco, Neubert, Laura, Groth, Marco, Rodriguez-Fraticelli, Alejo, Svendsen, Arthur Flohr, Campaner, Stefano, Andreas, Nico, Kamradt, Thomas, Hoffmann, Steve, Camargo, Fernando D., Heidel, Florian H., Bystrykh, Leonid V., de Haan, Gerald, von Eyss, Björn

“…Specific functions of the immune system are essential to protect us from infections caused by pathogens such as viruses and bacteria. However, as we age, the…”
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Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations by Ammer-Herrmenau, Christoph, Kulkarni, Upasana, Andreas, Nico, Ungelenk, Martin, Ravens, Sarina, Hübner, Christian, Kather, Angela, Kurth, Ingo, Bauer, Michael, Kamradt, Thomas

“…Massive apoptosis of lymphocytes is a hallmark of sepsis. The resulting immunosuppression is associated with secondary infections, which are often lethal…”
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Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes by Eitner, Annett, Müller, Sylvia, König, Christian, Wilharm, Arne, Raab, Rebecca, Hofmann, Gunther O, Kamradt, Thomas, Schaible, Hans-Georg

“…Interleukin (IL)-1β is an important pro-inflammatory cytokine in the progression of osteoarthritis (OA), which impairs mitochondrial function and induces the…”
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Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice by Omata, Yasunori, Frech, Michael, Primbs, Tatjana, Lucas, Sébastien, Andreev, Darja, Scholtysek, Carina, Sarter, Kerstin, Kindermann, Markus, Yeremenko, Nataliya, Baeten, Dominique L., Andreas, Nico, Kamradt, Thomas, Bozec, Aline, Ramming, Andreas, Krönke, Gerhard, Wirtz, Stefan, Schett, Georg, Zaiss, Mario M.

“…Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis…”
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Editorial: IL-1 Family Members in Health and Disease by Brint, Elizabeth, Kamradt, Thomas, Doyle, Sarah L

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Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17 by Muñoz, Melba, Heimesaat, Markus M, Danker, Kerstin, Struck, Daniela, Lohmann, Uwe, Plickert, Rita, Bereswill, Stefan, Fischer, André, Dunay, Ildikò Rita, Wolk, Kerstin, Loddenkemper, Christoph, Krell, Hans-Willi, Libert, Claude, Lund, Leif R, Frey, Oliver, Hölscher, Christoph, Iwakura, Yoichiro, Ghilardi, Nico, Ouyang, Wenjun, Kamradt, Thomas, Sabat, Robert, Liesenfeld, Oliver

“…Peroral infection with Toxoplasma gondii leads to the development of small intestinal inflammation dependent on Th1 cytokines. The role of Th17 cells in…”
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The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells by Göpfert, Christiane, Andreas, Nico, Weber, Franziska, Häfner, Norman, Yakovleva, Tatiana, Gaestel, Matthias, Kamradt, Thomas, Drube, Sebastian

“…IL-33 is an IL-1 cytokine superfamily member. Binding of IL-33 to the IL-33R induces activation of the canonical NF-κB signaling and activation of MAPKs. In…”
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Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis by Beckmann, Denise, Römer-Hillmann, Anja, Krause, Annika, Hansen, Uwe, Wehmeyer, Corinna, Intemann, Johanna, de Gorter, David J. J., Dankbar, Berno, Hillen, Jan, Heitzmann, Marianne, Begemann, Isabell, Galic, Milos, Weinhage, Toni, Foell, Dirk, Ai, Rizi, Kremerskothen, Joachim, Kiener, Hans P., Müller, Sylvia, Kamradt, Thomas, Schröder, Christopher, Leitão, Elsa, Horsthemke, Bernhard, Rosenstiel, Philip, Nordström, Karl, Gasparoni, Gilles, Gasparoni, Nina, Walter, Jörn, Li, Na, Yang, Xinyi, Chung, Ho-Ryun, Pavenstädt, Hermann, Lindemann, Nico, Schnittler, Hans J., Wang, Wei, Firestein, Gary S., Pap, Thomas, Korb-Pap, Adelheid

“…The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with…”
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MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation by Drube, Sebastian, Kraft, Florian, Dudeck, Jan, Müller, Anna-Lena, Weber, Franziska, Göpfert, Christiane, Meininger, Isabel, Beyer, Mandy, Irmler, Ingo, Häfner, Norman, Schütz, Dagmar, Stumm, Ralf, Yakovleva, Tatiana, Gaestel, Matthias, Dudeck, Anne, Kamradt, Thomas

“…The IL-1R family member IL-33R mediates Fcε-receptor-I (FcεRI)-independent activation of mast cells leading to NF-κB activation and consequently the production…”
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Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells by Baschant, Ulrike, Frappart, Lucien, Rauchhaus, Una, Bruns, Lisa, Reichardt, Holger M, Kamradt, Thomas, Bräuer, Rolf, Tuckermann, Jan P

“…Despite several side effects, glucocorticoids (GCs) have been widely used for 60 y to treat rheumatoid arthritis on the basis of their antiinflammatory…”
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Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging by Andreas, Nico, Müller, Sylvia, Templin, Nicole, Jordan, Paul M, Schuhwerk, Harald, Müller, Michael, Gerstmeier, Jana, Miek, Laura, Andreas, Saskia, Werz, Oliver, Kamradt, Thomas

“…Abstract Background The incidence of rheumatoid arthritis is correlated with age. In this study, we analyzed the association of the incidence and severity of…”
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Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection—The CoNAN long-term study by Schnizer, Clara, Andreas, Nico, Vivas, Wolfgang, Kamradt, Thomas, Baier, Michael, Kiehntopf, Michael, Glöckner, Stefan, Scherag, André, Löffler, Bettina, Kolanos, Steffi, Guerra, Joel, Pletz, Mathias W., Weis, Sebastian

“…Understanding persistent cellular and humoral immune responses to SARS-CoV-2 will be of major importance to terminate the ongoing pandemic. Here, we assessed…”
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