Search Results - "KAMPS, G"

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  1. 1

    Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease by Brewitz, Lennart, Kamps, Jos J. A. G., Lukacik, Petra, Strain‐Damerell, Claire, Zhao, Yilin, Tumber, Anthony, Malla, Tika R., Orville, Allen M., Walsh, Martin A., Schofield, Christopher J.

    Published in ChemMedChem (04-05-2022)
    “…The two SARS‐CoV‐2 proteases, i. e. the main protease (Mpro) and the papain‐like protease (PLpro), which hydrolyze the viral polypeptide chain giving…”
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  2. 2

    Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis by Rabe, Patrick, Kamps, Jos J A G, Schofield, Christopher J, Lohans, Christopher T

    Published in Natural product reports (15-08-2018)
    “…Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the…”
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    Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation by Schiedel, Matthias, Moroglu, Mustafa, Ascough, David M. H., Chamberlain, Anna E. R., Kamps, Jos J. A. G., Sekirnik, Angelina R., Conway, Stuart J.

    Published in Angewandte Chemie International Edition (09-12-2019)
    “…Epigenetics is currently the focus of intense research interest across a broad range of disciplines due to its importance in a multitude of biological…”
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    Ray‐tracing analytical absorption correction for X‐ray crystallography based on tomographic reconstructions by Lu, Yishun, Duman, Ramona, Beilsten-Edmands, James, Winter, Graeme, Basham, Mark, Evans, Gwyndaf, Kamps, Jos J. A. G., Orville, Allen M., Kwong, Hok-Sau, Beis, Konstantinos, Armour, Wesley, Wagner, Armin

    Published in Journal of applied crystallography (01-06-2024)
    “…Processing of single‐crystal X‐ray diffraction data from area detectors can be separated into two steps. First, raw intensities are obtained by integration of…”
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    Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins by Belle, Roman, Kamps, Jos J. A. G., Poater, Jordi, Kumar, Kiran, Pieters, Bas J. G. E., Salah, Eidarus, Claridge, Timothy D. W., Paton, Robert S., Bickelhaupt, F. Matthias, Kawamura, Akane, Schofield, Christopher J., Mecinović, Jasmin

    Published in Communications chemistry (01-12-2022)
    “…N ε -Methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription. The ‘highest’ methylation mark, N ε…”
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  7. 7

    A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer by RIEZEBOS-BRILMAN, A, WALCZAK, M, REGTS, J, ROTS, M. G, KAMPS, G, DONTJE, B, HAISMA, H. Y, WILSCHUT, J, DAEMEN, T

    Published in Gene therapy (01-12-2007)
    “…Currently, various therapeutic strategies are being explored as a potential means to immunize against metastatic malignant cells or even primary tumours. Using…”
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  8. 8

    Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases by Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D, Lang, Pauline A, Kamps, Jos J. A. G, Tyrrell, Jonathan M, Widlake, Emma, Saward, Benjamin G, Walsh, Timothy R, Spencer, James, Schofield, Christopher J

    Published in Journal of medicinal chemistry (26-09-2019)
    “…The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits…”
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    Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation by Pieters, Bas J. G. E, Hintzen, Jordi C. J, Grobben, Yvonne, Al Temimi, Abbas H. K, Kamps, Jos J. A. G, Mecinović, Jasmin

    Published in Bioconjugate chemistry (20-03-2019)
    “…Site-specific incorporation of post-translationally modified amino acids into proteins, including histones, has been a subject of great interest for chemical…”
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  11. 11

    Adherence to the guidelines of a regional formulary by Kamps, GB, Stewart, RE, van der Werf, GTh, Schuling, J, Jong, B Meyboom-de

    Published in Family practice (01-06-2000)
    “…Background. Pharmacotherapeutical guidelines, called formularies, have been developed to facilitate effective, efficient and cost-conscious prescribing…”
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    Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger by Pieters, Bas J. G. E., Wuts, Maud H. M., Poater, Jordi, Kumar, Kiran, White, Paul B., Kamps, Jos J. A. G., Sherman, Woody, Pruijn, Ger J. M., Paton, Robert S., Beuming, Thijs, Bickelhaupt, F. Matthias, Mecinović, Jasmin

    Published in Communications chemistry (01-06-2020)
    “…The understanding of biomolecular recognition of posttranslationally modified histone proteins is centrally important to the histone code hypothesis. Despite…”
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    The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors by White, Mark D., Kamps, Jos J. A.G., East, Samuel, Taylor Kearney, Leah J., Flashman, Emily

    Published in The Journal of biological chemistry (27-07-2018)
    “…Group VII ethylene response factors (ERF-VIIs) regulate transcriptional adaptation to flooding-induced hypoxia in plants. ERF-VII stability is controlled in an…”
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  16. 16

    How formaldehyde reacts with amino acids by Kamps, Jos J. A. G., Hopkinson, Richard J., Schofield, Christopher J., Claridge, Timothy D. W.

    Published in Communications chemistry (07-11-2019)
    “…Formaldehyde is a biological electrophile produced via processes including enzymatic demethylation. Despite its apparent simplicity, the reactions of…”
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  17. 17

    Chemische Epigenetik: der Einfluss chemischer und chemo‐biologischer Techniken auf die Zielstruktur‐Validierung von Bromodomänen by Schiedel, Matthias, Moroglu, Mustafa, Ascough, David M H, Chamberlain, Anna E R, Jos J A G Kamps, Sekirnik, Angelina R, Conway, Stuart J

    Published in Angewandte Chemie (01-12-2019)
    “…Viele Disziplinen befassen sich gegenwärtig mit Epigenetik, da diese von Bedeutung für viele biologische Vorgänge und pathologische Zustände ist. Auf…”
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    Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins by Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin

    Published in Nature communications (18-11-2015)
    “…A large number of structurally diverse epigenetic reader proteins specifically recognize methylated lysine residues on histone proteins. Here we describe…”
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    19 F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode by Leśniak, Robert K, Rydzik, Anna M, Kamps, Jos J A G, Kahn, Amjad, Claridge, Timothy D W, Schofield, Christopher J

    “…The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine…”
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