Search Results - "KAMPS, G"
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Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease
Published in ChemMedChem (04-05-2022)“…The two SARS‐CoV‐2 proteases, i. e. the main protease (Mpro) and the papain‐like protease (PLpro), which hydrolyze the viral polypeptide chain giving…”
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Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Published in Natural product reports (15-08-2018)“…Covering: up to 2017 2-Oxoglutarate (2OG) dependent oxygenases and the homologous oxidase isopenicillin N synthase (IPNS) play crucial roles in the…”
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Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation
Published in Angewandte Chemie International Edition (09-12-2019)“…Epigenetics is currently the focus of intense research interest across a broad range of disciplines due to its importance in a multitude of biological…”
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Ray‐tracing analytical absorption correction for X‐ray crystallography based on tomographic reconstructions
Published in Journal of applied crystallography (01-06-2024)“…Processing of single‐crystal X‐ray diffraction data from area detectors can be separated into two steps. First, raw intensities are obtained by integration of…”
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Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Published in Angewandte Chemie International Edition (11-02-2019)“…Enzymes often use nucleophilic serine, threonine, and cysteine residues to achieve the same type of reaction; the underlying reasons for this are not…”
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Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins
Published in Communications chemistry (01-12-2022)“…N ε -Methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription. The ‘highest’ methylation mark, N ε…”
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A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer
Published in Gene therapy (01-12-2007)“…Currently, various therapeutic strategies are being explored as a potential means to immunize against metastatic malignant cells or even primary tumours. Using…”
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Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Published in Journal of medicinal chemistry (26-09-2019)“…The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits…”
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Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation
Published in Bioconjugate chemistry (20-03-2019)“…Site-specific incorporation of post-translationally modified amino acids into proteins, including histones, has been a subject of great interest for chemical…”
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Adherence to the guidelines of a regional formulary
Published in Family practice (01-06-2000)“…Background. Pharmacotherapeutical guidelines, called formularies, have been developed to facilitate effective, efficient and cost-conscious prescribing…”
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Non‐Hydrolytic β‐Lactam Antibiotic Fragmentation by l,d‐Transpeptidases and Serine β‐Lactamase Cysteine Variants
Published in Angewandte Chemie (11-02-2019)“…Enzymes often use nucleophilic serine, threonine, and cysteine residues to achieve the same type of reaction; the underlying reasons for this are not…”
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Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger
Published in Communications chemistry (01-06-2020)“…The understanding of biomolecular recognition of posttranslationally modified histone proteins is centrally important to the histone code hypothesis. Despite…”
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The adaptability of the ion-binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF
Published in The Journal of biological chemistry (01-11-2023)“…The periplasmic chaperone SilF has been identified as part of an Ag(I) detoxification system in Gram-negative bacteria. Sil proteins also bind Cu(I) but with…”
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The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors
Published in The Journal of biological chemistry (27-07-2018)“…Group VII ethylene response factors (ERF-VIIs) regulate transcriptional adaptation to flooding-induced hypoxia in plants. ERF-VII stability is controlled in an…”
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How formaldehyde reacts with amino acids
Published in Communications chemistry (07-11-2019)“…Formaldehyde is a biological electrophile produced via processes including enzymatic demethylation. Despite its apparent simplicity, the reactions of…”
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Chemische Epigenetik: der Einfluss chemischer und chemo‐biologischer Techniken auf die Zielstruktur‐Validierung von Bromodomänen
Published in Angewandte Chemie (01-12-2019)“…Viele Disziplinen befassen sich gegenwärtig mit Epigenetik, da diese von Bedeutung für viele biologische Vorgänge und pathologische Zustände ist. Auf…”
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Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins
Published in Nature communications (18-11-2015)“…A large number of structurally diverse epigenetic reader proteins specifically recognize methylated lysine residues on histone proteins. Here we describe…”
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19 F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode
Published in Chemical communications (Cambridge, England) (05-12-2019)“…The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine…”
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Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
Published in Bioorganic & medicinal chemistry (15-07-2018)“…[Display omitted] Metallo-β-lactamases (MBLs) enable bacterial resistance to almost all classes of β-lactam antibiotics. We report studies on enethiol…”
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