Search Results - "KAMM, Walter"

Microwell Plate-Based Dynamic Light Scattering as a High-Throughput Characterization Tool in Biopharmaceutical Development by Dauer, Katharina, Pfeiffer-Marek, Stefania, Kamm, Walter, Wagner, Karl G

“…High-throughput light scattering instruments are widely used in screening of biopharmaceutical formulations and can be easily incorporated into processes by…”
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High-Throughput Screening for Colloidal Stability of Peptide Formulations Using Dynamic and Static Light Scattering by Dauer, Katharina, Kamm, Walter, Wagner, Karl Gerhard, Pfeiffer-Marek, Stefania

“…Selection of an appropriate formulation to stabilize therapeutic proteins against aggregation is one of the most challenging tasks in early-stage drug product…”
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Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical Properties Toward Specific Formulation Requirements by Evers, Andreas, Pfeiffer-Marek, Stefania, Bossart, Martin, Heubel, Christoph, Stock, Ursula, Tiwari, Garima, Gebauer, Birgit, Elshorst, Bettina, Pfenninger, Anja, Lukasczyk, Ulrike, Hessler, Gerhard, Kamm, Walter, Wagner, Michael

“…Physicochemical properties of peptides need to be compatible with the manufacturing process and formulation requirements to ensure developability toward the…”
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Biorelevant subcutaneous in vitro test predicts the release of human and fast acting insulin formulations by Schöner, Tim A., Vogel, Verena, Venczel, Marta, Knoth, Katharina, Kamm, Walter, Paehler, Tobias, Louit, Guillaume, Terán, Iria Torres, Mundinger, Patricia, Marker, Alexander, Loos, Petra, Hittinger, Marius, Lehr, Claus-Michael

“…[Display omitted] The administration of insulins by subcutaneous injection is nowadays widely prevalent. The injection site is located below the dermis and…”
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An integrated early formulation strategy – From hit evaluation to preclinical candidate profiling by Maas, Jochen, Kamm, Walter, Hauck, Gerrit

“…The selection of a suitable vehicle for preclinical compound profiling is a very important task during the early developmental phases to ensure the quality of…”
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Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery by Liu, Yun, Hamm, Timo, Eichinger, Thomas Ralf, Kamm, Walter, Wieland, Heike Andrea, Loretz, Brigitta, Hirsch, Anna K H, Lee, Sangeun, Lehr, Claus-Michael

“…Therapeutic proteins and peptides offer great advantages compared to traditional synthetic molecular drugs. However, stable protein loading and precise control…”
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Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin by Behrens, Isabel, Kamm, Walter, Dantzig, Anne H, Kissel, Thomas

“…Caco-2 cell cultures are a widely used in vitro model for the small intestinal drug transport, although large differences have been reported for actively…”
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Tetanus toxoid loaded nanoparticles from sulfobutylated poly(Vinyl Alcohol)-Graft-Poly(Lactide-co-Glycolide): Evaluation of antibody response after oral and nasal application in mice by JUNG, Tobias, KAMM, Walter, BREITENBACH, Armin, HUNGERER, Klaus-Dieter, HUNDT, Erika, KISSEL, Thomas

“…Aim of the study was the evaluation of the potential of novel tetanus toxoid (TT) loaded nanoparticles (NP) for electing an immune response in mice against TT…”
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Loading of tetanus toxoid to biodegradable nanoparticles from branched poly(sulfobutyl-polyvinyl alcohol)-g-(lactide-co-glycolide) nanoparticles by protein adsorption: A mechanistic study by JUNG, Tobias, KAMM, Walter, BREITENBACH, Armin, KLEBE, Gerhard, KISSEL, Thomas

“…Mucosal delivery of vaccine-loaded nanoparticles (NP) is an attractive proposition from an immunologic perspective. Although numerous NP preparation methods…”
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Prodrug Approach for [alpha]^sub IIb^[beta]^sub 3^Peptidomimetic Antagonists to Enhance Their Transport in Monolayers of a Human Intestinal Cell Line (Caco-2): Comparison of In Vitro and In Vivo Data by Kamm, Walter, Raddatz, Peter, Gante, Joachim, Kissel, Thomas

“…Different lipophilic derivatives of a potent alphaIIbbeta3-antagonist with benzamidino-oxazolidinone structure were investigated with respect to transport and…”
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Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure : Permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2) by KAMM, Walter, HAUPTMANN, Jörg, BEHRENS, Isabel, STÜRZEBECHER, Jörg, DULLWEBER, Frank, GOHLKE, Holger, STUBBS, Milton, KLEBE, Gerhard, KISSEL, Thomas

“…Peptidomimetic thrombin inhibitors derived from Nalpha-(2-naphthylsulfonyl)-3-amidino-phenylalanine with different basic and acidic substituents were…”
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Evaluation of absorption enhancement for a potent cyclopeptidic ανβ3-antagonist in a human intestinal cell line (Caco-2) by Kamm, Walter, Jonczyk, Alfred, Jung, Tobias, Luckenbach, Gerd, Raddatz, Peter, Kissel, Thomas

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Evaluation of absorption enhancement for a potent cyclopeptidic α νβ 3-antagonist in a human intestinal cell line (Caco-2) by Kamm, Walter, Jonczyk, Alfred, Jung, Tobias, Luckenbach, Gerd, Raddatz, Peter, Kissel, Thomas

“…Different absorption enhancing principles for a potent cyclopeptidic α νβ 3-antagonist (EMD 121974) were investigated in monolayers of a human intestinal cell…”
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