Search Results - "KAMINUMA, Osamu"

Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development by Kitamura, Noriko, Kaminuma, Osamu

“…Nuclear factor of activated T cells (NFAT), which is the pharmacological target of immunosuppressants cyclosporine and tacrolimus, has been shown to play an…”
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From the genesis to the present: The evolution of sublingual immunotherapy for cedar pollinosis by Gotoh, Minoru, Kaminuma, Osamu, Okubo, Kimihiro

“…In 2004, we started the initial attempt to evaluate the efficacy of SLIT for Japanese cedar pollinosis (JCP) using Japanese cedar (JC) pollen extract solution…”
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Role of CD4 + T Cells in Allergic Airway Diseases: Learning from Murine Models by Miura, Kento, Inoue, Kimiko, Ogura, Atsuo, Kaminuma, Osamu

“…The essential contribution of CD4 T cells in allergic airway diseases has been demonstrated, especially by using various murine models of antigen-induced…”
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Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates by Gamboa, Maribet, Kitamura, Noriko, Miura, Kento, Noda, Satoko, Kaminuma, Osamu

“…The mechanisms of immunity linked to biological evolution are crucial for understanding animal morphogenesis, organogenesis, and biodiversity. The nuclear…”
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BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress‐related tumorigenicity by Takemoto, Kenshiro, Kobatake, Kohei, Miura, Kento, Fukushima, Takafumi, Babasaki, Takashi, Miyamoto, Shunsuke, Sekino, Yohei, Kitano, Hiroyuki, Goto, Keisuke, Ikeda, Kenichiro, Hieda, Keisuke, Hayashi, Tetsutaro, Hinata, Nobuyuki, Kaminuma, Osamu

“…The carcinogenesis and progression of renal cell carcinoma (RCC), a heterogeneous cancer derived from renal tubular epithelial cells, is closely related to…”
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Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells by Nakata, Yuichiro, Miura, Kento, Yamasaki, Norimasa, Ogata, Sawako, Miura, Shuka, Hosomi, Naohisa, Kaminuma, Osamu

“…A contribution of the cholinergic system to immune cell function has been suggested, though the role of nicotine and its receptors in T cells, especially…”
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Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1 by Hayashi, Keitaro, Kaminuma, Osamu

“…Bronchial asthma is a chronic disease characterized by airway inflammation, obstruction, and hyperresponsiveness. CD4 T cells, particularly T helper (Th) 2…”
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Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner by Watanabe, Nobumasa, Kaminuma, Osamu, Kitamura, Noriko, Hiroi, Takachika

“…Th17 cells and Foxp3+ regulatory T cells (Tregs) are thought to promote and suppress inflammatory responses, respectively. However, whether they counteract…”
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Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA by Shibata, Akitaka, M.D., Ph.D, Sugiura, Kazumitsu, M.D., Ph.D, Furuta, Yasuhide, Ph.D, Mukumoto, Yoshiko, Kaminuma, Osamu, D.V.M., Ph.D, Akiyama, Masashi, M.D., Ph.D

“…Abstract Background IL36RN encodes the IL-36 receptor antagonist (IL-36Ra), and loss-of-function mutations in IL36RN define a recessively inherited…”
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T Cell-Mediated Nasal Hyperresponsiveness in Allergic Rhinitis by Kaminuma, Osamu, Nishimura, Tomoe, Saeki, Mayumi, Mori, Akio, Hiroi, Takachika

“…Allergic rhinitis patients suffer various symptoms such as sneezing, runny nose, and nasal congestion. As disease severity and chronicity progress, nasal…”
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Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness by Uda, Naoto, Ogata, Sawako, Yamasaki, Norimasa, Miura, Shuka, Hosomi, Naohisa, Mori, Akio, Gotoh, Minoru, Miura, Kento, Kaminuma, Osamu

“…T cells play an essential role in the development of allergen-induced nasal hyperresponsiveness (NHR), a pathophysiological response in allergic rhinitis. The…”
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L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness by Kaminuma, Osamu, Nishimura, Tomoe, Saeki, Mayumi, Yamasaki, Norimasa, Ogata, Sawako, Fujita, Tomoe, Endou, Hitoshi, Hayashi, Keitaro

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PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1 by Nakata, Yuichiro, Nagasawa, Shion, Sera, Yasuyuki, Yamasaki, Norimasa, Kanai, Akinori, Kobatake, Kohei, Ueda, Takeshi, Koizumi, Miho, Manabe, Ichiro, Kaminuma, Osamu, Honda, Hiroaki

“…The genome is constantly exposed to DNA damage from endogenous and exogenous sources. Fine modulation of DNA repair, chromatin remodeling, and transcription…”
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Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action by Gotoh, Minoru, Kaminuma, Osamu

“…Owing to the successful application of sublingual immunotherapy (SLIT), allergen immunotherapy (AIT) has become one of the leading treatments for allergic…”
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Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells by Kaminuma, Osamu, Kitamura, Noriko, Nishito, Yasumasa, Nemoto, Soichi, Tatsumi, Hideki, Mori, Akio, Hiroi, Takachika

“…The NFAT family transcription factors play crucial roles in immunological and other biological activities. NFAT3 is rarely expressed in T cells, and the…”
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Potential Mechanisms of T Cell-Mediated and Eosinophil-Independent Bronchial Hyperresponsiveness by Saeki, Mayumi, Nishimura, Tomoe, Kitamura, Noriko, Hiroi, Takachika, Mori, Akio, Kaminuma, Osamu

“…Bronchial asthma is a chronic disease characterized by reversible airway obstruction, mucus production, and bronchial hyperresponsiveness (BHR). Although Th2…”
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Progress of genome editing technology and developmental biology useful for radiation research by Miura, Kento, Ogura, Atsuo, Kobatake, Kohei, Honda, Hiroaki, Kaminuma, Osamu

“…Following the development of genome editing technology, it has become more feasible to create genetically modified animals such as knockout (KO), knock-in, and…”
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Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis by Gotoh, Minoru, Kaminuma, Osamu, Nakaya, Akihiro, Katayama, Kazufumi, Motoi, Yuji, Watanabe, Nobumasa, Saeki, Mayumi, Nishimura, Tomoe, Kitamura, Noriko, Yamaoka, Kazuko, Okubo, Kimihiro, Hiroi, Takachika

“…Sublingual immunotherapy (SLIT) is effective against allergic rhinitis, although a substantial proportion of individuals is refractory. Herein, we describe a…”
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Epicutaneous allergen administration without antigen delivery device induces local T cell response and alleviates food allergic enteropathy by Morinaga, Mamiko, Nakajima-Adachi, Haruyo, Hiraide, Erika, Kitamura, Noriko, Kaminuma, Osamu, Hiroi, Takachika, Ohashi-Doi, Katsuyo, Hachimura, Satoshi

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Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice by Saeki, Mayumi, Kaminuma, Osamu, Nishimura, Tomoe, Kitamura, Noriko, Mori, Akio, Hiroi, Takachika

“…Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate…”
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