Search Results - "KAMINSKI, Rafal"

Molecular Biology of Meniscal Healing: A Narrative Review by Tramś, Ewa, Kamiński, Rafał

“…This review provides insights at the molecular level into the current and old methods for treating meniscal injuries. Meniscal injuries have been found to have…”
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Genetic variability of the endangered fish lake minnow (Eupallasella percnurus) in populations newly established by translocation and those existing long term in Poland by Wolnicki, Jacek, Kaczmarczyk, Dariusz, Sikorska, Justyna, Kamiński, Rafał, Osińska, Adriana, Zawrotna, Natalia

“…The lake minnow Eupallasella percnurus is a small leuciscid fish. In Poland, this species has been in a continuous decline since the mid-20th century and is…”
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New epilepsy therapies in development by Klein, Pavel, Kaminski, Rafal M., Koepp, Matthias, Löscher, Wolfgang

“…Epilepsy is a common brain disorder, characterized by spontaneous recurrent seizures, with associated neuropsychiatric and cognitive comorbidities and…”
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Commonalities in epileptogenic processes from different acute brain insults: Do they translate? by Klein, Pavel, Dingledine, Raymond, Aronica, Eleonora, Bernard, Christophe, Blümcke, Ingmar, Boison, Detlev, Brodie, Martin J., Brooks‐Kayal, Amy R., Engel, Jerome, Forcelli, Patrick A., Hirsch, Lawrence J., Kaminski, Rafal M., Klitgaard, Henrik, Kobow, Katja, Lowenstein, Daniel H., Pearl, Phillip L., Pitkänen, Asla, Puhakka, Noora, Rogawski, Michael A., Schmidt, Dieter, Sillanpää, Matti, Sloviter, Robert S., Steinhäuser, Christian, Vezzani, Annamaria, Walker, Matthew C., Löscher, Wolfgang

“…Summary The most common forms of acquired epilepsies arise following acute brain insults such as traumatic brain injury, stroke, or central nervous system…”
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Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models by Leclercq, Karine, Matagne, Alain, Provins, Laurent, Klitgaard, Henrik, Kaminski, Rafal M.

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Genetic background of mice strongly influences treatment resistance in the 6 Hz seizure model by Leclercq, Karine, Kaminski, Rafal M.

“…Summary Objective The 6 Hz model of focal seizures has been increasingly used to identify anticonvulsant compounds with potential activity against…”
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The effectiveness of quadrupled semitendinosus graft technique in anterior cruciate ligament reconstruction: A network meta-analysis assessing various graft preparation techniques by Malesa, Kamila, Tramś, Ewa, Kuliński, Krzysztof, Kamiński, Rafał

“…This study aims to perform a network meta-analysis of hamstring graft preparation techniques to enhance anterior cruciate ligament (ACL) reconstruction…”
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RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection by Hu, Wenhui, Kaminski, Rafal, Yang, Fan, Zhang, Yonggang, Cosentino, Laura, Li, Fang, Luo, Biao, Alvarez-Carbonell, David, Garcia-Mesa, Yoelvis, Karn, Jonathan, Mo, Xianming, Khalili, Kamel

“…AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even after antiretroviral therapy…”
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A systems-level framework for anti-epilepsy drug discovery by Johnson, Michael R., Kaminski, Rafal M.

“…Modern anti-seizure drug development yielded benefits in terms of improved pharmacokinetics, safety and tolerability profiles, but offered no advances in…”
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Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond by Löscher, Wolfgang, Gillard, Michel, Sands, Zara A., Kaminski, Rafal M., Klitgaard, Henrik

“…The synaptic vesicle glycoprotein SV2A belongs to the major facilitator superfamily (MFS) of transporters and is an integral constituent of synaptic vesicle…”
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Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy? by Klein, Pavel, Friedman, Alon, Hameed, Mustafa Q., Kaminski, Rafal M., Bar‐Klein, Guy, Klitgaard, Henrik, Koepp, Mathias, Jozwiak, Sergiusz, Prince, David A., Rotenberg, Alexander, Twyman, Roy, Vezzani, Annamaria, Wong, Michael, Löscher, Wolfgang

“…Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults such as traumatic brain injury (TBI), cerebrovascular accidents (CVA),…”
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Discovery of (R)‑N‑Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS‑1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo by Abram, Michał, Jakubiec, Marcin, Reeb, Katelyn, Cheng, Mary Hongying, Gedschold, Robin, Rapacz, Anna, Mogilski, Szczepan, Socała, Katarzyna, Nieoczym, Dorota, Szafarz, Małgorzata, Latacz, Gniewomir, Szulczyk, Bartłomiej, Kalinowska-Tłuścik, Justyna, Gawel, Kinga, Esguerra, Camila V., Wyska, Elżbieta, Müller, Christa E., Bahar, Ivet, Fontana, Andréia C. K., Wlaź, Piotr, Kamiński, Rafał M., Kamiński, Krzysztof

“…( R )-7 [( R )-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute…”
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Neuroinflammatory targets and treatments for epilepsy validated in experimental models by Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaufer, Daniela, Koh, Sookyong, Löscher, Wolfgang, Louboutin, Jean‐Pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria, Kaminski, Rafal M.

“…Summary A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy…”
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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment by Klitgaard, Henrik, Matagne, Alain, Nicolas, Jean‐Marie, Gillard, Michel, Lamberty, Yves, De Ryck, Marc, Kaminski, Rafal M., Leclercq, Karine, Niespodziany, Isabelle, Wolff, Christian, Wood, Martyn, Hannestad, Jonas, Kervyn, Sophie, Kenda, Benoit

“…Summary Despite availability of effective antiepileptic drugs (AEDs), many patients with epilepsy continue to experience refractory seizures and adverse…”
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TRPV1 channel in the pathophysiology of epilepsy and its potential as a molecular target for the development of new antiseizure drug candidates by Socała, Katarzyna, Jakubiec, Marcin, Abram, Michał, Mlost, Jakub, Starowicz, Katarzyna, Kamiński, Rafał M., Ciepiela, Katarzyna, Andres-Mach, Marta, Zagaja, Mirosław, Metcalf, Cameron S., Zawadzki, Przemysław, Wlaź, Piotr, Kamiński, Krzysztof

“…Identification of transient receptor potential cation channel, subfamily V member 1 (TRPV1), also known as capsaicin receptor, in 1997 was a milestone…”
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KA‐104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models by Kamiński, Krzysztof, Mogilski, Szczepan, Abram, Michał, Rapacz, Anna, Latacz, Gniewomir, Szulczyk, Bartłomiej, Walczak, Maria, Kuś, Kamil, Matyjaszczyk, Karolina, Kamiński, Rafał M.

“…Objective The main objective of the present work was to assess the utility of KA‐104 as potential therapy for drug‐resistant seizures and neuropathic pain, and…”
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Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice by Dash, Prasanta K., Kaminski, Rafal, Bella, Ramona, Su, Hang, Mathews, Saumi, Ahooyi, Taha M., Chen, Chen, Mancuso, Pietro, Sariyer, Rahsan, Ferrante, Pasquale, Donadoni, Martina, Robinson, Jake A., Sillman, Brady, Lin, Zhiyi, Hilaire, James R., Banoub, Mary, Elango, Monalisha, Gautam, Nagsen, Mosley, R. Lee, Poluektova, Larisa Y., McMillan, JoEllyn, Bade, Aditya N., Gorantla, Santhi, Sariyer, Ilker K., Burdo, Tricia H., Young, Won-Bin, Amini, Shohreh, Gordon, Jennifer, Jacobson, Jeffrey M., Edagwa, Benson, Khalili, Kamel, Gendelman, Howard E.

“…Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective…”
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Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy by Mazzuferi, Manuela, Kumar, Gaurav, van Eyll, Jonathan, Danis, Benedicte, Foerch, Patrik, Kaminski, Rafal M.

“…Objective Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for…”
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The Potential of Antiseizure Drugs and Agents that Act on Novel Molecular Targets as Antiepileptogenic Treatments by Kaminski, Rafal M., Rogawski, Michael A., Klitgaard, Henrik

“…A major goal of contemporary epilepsy research is the identification of therapies to prevent the development of recurrent seizures in individuals at risk,…”
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Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization by Mazzuferi, Manuela, Kumar, Gaurav, Rospo, Chiara, Kaminski, Rafal M.

“…Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy and several rodent models allow studying the pathophysiology of this disorder…”
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