Search Results - "KAMINSKI, Naftali"

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis by Tsukui, Tatsuya, Sun, Kai-Hui, Wetter, Joseph B., Wilson-Kanamori, John R., Hazelwood, Lisa A., Henderson, Neil C., Adams, Taylor S., Schupp, Jonas C., Poli, Sergio D., Rosas, Ivan O., Kaminski, Naftali, Matthay, Michael A., Wolters, Paul J., Sheppard, Dean

“…Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell…”
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Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice by Wong, Christine K, Smith, Candice A, Sakamoto, Koji, Kaminski, Naftali, Koff, Jonathan L, Goldstein, Daniel R

“…Influenza viral infections often lead to increased mortality in older people. However, the mechanisms by which aging impacts immunity to influenza lung…”
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Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype by Camiolo, Matthew, Gauthier, Marc, Kaminski, Naftali, Ray, Anuradha, Wenzel, Sally E.

“…More than 300 million people carry a diagnosis of asthma, with data to suggest that they are at a higher risk for infection or adverse outcomes from severe…”
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Epigenetics in idiopathic pulmonary fibrosis by Tzouvelekis, Argyrios, Kaminski, Naftali

“…Idiopathic pulmonary fibrosis (IPF) is a lethal chronic lung disorder with no effective treatment and a prognosis worse than that of lung cancer. Despite…”
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The Idiopathic Pulmonary Fibrosis Cell Atlas by Neumark, Nir, Cosme, Jr, Carlos, Rose, Kadi-Ann, Kaminski, Naftali

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Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? by Selman, Moisés, Pardo, Annie, Kaminski, Naftali

“…The authors discuss evidence suggesting that embryonic signaling pathways involved in epithelium/mesenchymal communication and epithelial cell plasticity may…”
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Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome by Raredon, Micha Sam Brickman, Yang, Junchen, Garritano, James, Wang, Meng, Kushnir, Dan, Schupp, Jonas Christian, Adams, Taylor S., Greaney, Allison M., Leiby, Katherine L., Kaminski, Naftali, Kluger, Yuval, Levchenko, Andre, Niklason, Laura E.

“…Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the…”
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Biomarkers in idiopathic pulmonary fibrosis by Zhang, Yingze, Kaminski, Naftali

“…PURPOSE OF REVIEWThis review examines the recent literature on molecular biomarkers of idiopathic pulmonary fibrosis (IPF). Specific attention is dedicated to…”
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Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis by Chandran, Rachana R., Xie, Yi, Gallardo-Vara, Eunate, Adams, Taylor, Garcia-Milian, Rolando, Kabir, Inamul, Sheikh, Abdul Q., Kaminski, Naftali, Martin, Kathleen A., Herzog, Erica L., Greif, Daniel M.

“…During lung fibrosis, the epithelium induces signaling to underlying mesenchyme to generate excess myofibroblasts and extracellular matrix; herein, we focus on…”
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Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis by Adams, Taylor S, Schupp, Jonas C, Poli, Sergio, Ayaub, Ehab A, Neumark, Nir, Ahangari, Farida, Chu, Sarah G, Raby, Benjamin A, DeIuliis, Giuseppe, Januszyk, Michael, Duan, Qiaonan, Arnett, Heather A, Siddiqui, Asim, Washko, George R, Homer, Robert, Yan, Xiting, Rosas, Ivan O, Kaminski, Naftali

“…We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells from 32 IPF, 28 smoker and…”
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Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs by Phinney, Donald G., Di Giuseppe, Michelangelo, Njah, Joel, Sala, Ernest, Shiva, Sruti, St Croix, Claudette M., Stolz, Donna B., Watkins, Simon C., Di, Y. Peter, Leikauf, George D., Kolls, Jay, Riches, David W. H., Deiuliis, Giuseppe, Kaminski, Naftali, Boregowda, Siddaraju V., McKenna, David H., Ortiz, Luis A.

“…Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the stem cell niche and function coordinately to regulate haematopoietic stem cell…”
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function by Yu, Guoying, Tzouvelekis, Argyris, Wang, Rong, Herazo-Maya, Jose D, Ibarra, Gabriel H, Srivastava, Anup, de Castro, Joao Pedro Werneck, DeIuliis, Giuseppe, Ahangari, Farida, Woolard, Tony, Aurelien, Nachelle, Arrojo e Drigo, Rafael, Gan, Ye, Graham, Morven, Liu, Xinran, Homer, Robert J, Scanlan, Thomas S, Mannam, Praveen, Lee, Patty J, Herzog, Erica L, Bianco, Antonio C, Kaminski, Naftali

“…Thyroid hormone improves mitochondrial function and dynamics in lung epithelium to reduce pulmonary fibrosis in mice. Thyroid hormone (TH) is critical for the…”
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miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis by Liu, Gang, Friggeri, Arnaud, Yang, Yanping, Milosevic, Jadranka, Ding, Qiang, Thannickal, Victor J, Kaminski, Naftali, Abraham, Edward

“…Uncontrolled extracellular matrix production by fibroblasts in response to tissue injury contributes to fibrotic diseases, such as idiopathic pulmonary…”
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Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells by Sumida, Tomokazu S., Dulberg, Shai, Schupp, Jonas C., Lincoln, Matthew R., Stillwell, Helen A., Axisa, Pierre-Paul, Comi, Michela, Unterman, Avraham, Kaminski, Naftali, Madi, Asaf, Kuchroo, Vijay K., Hafler, David A.

“…Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not…”
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BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis by Prasse, Antje, Binder, Harald, Schupp, Jonas C, Kayser, Gian, Bargagli, Elena, Jaeger, Benedikt, Hess, Moritz, Rittinghausen, Susanne, Vuga, Louis, Lynn, Heather, Violette, Shelia, Jung, Birgit, Quast, Karsten, Vanaudenaerde, Bart, Xu, Yan, Hohlfeld, Jens M, Krug, Norbert, Herazo-Maya, Jose D, Rottoli, Paola, Wuyts, Wim A, Kaminski, Naftali

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable course. To determine whether BAL cell gene expression is predictive of…”
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The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease by Schiller, Herbert B, Montoro, Daniel T, Simon, Lukas M, Rawlins, Emma L, Meyer, Kerstin B, Strunz, Maximilian, Vieira Braga, Felipe A, Timens, Wim, Koppelman, Gerard H, Budinger, G R Scott, Burgess, Janette K, Waghray, Avinash, van den Berge, Maarten, Theis, Fabian J, Regev, Aviv, Kaminski, Naftali, Rajagopal, Jayaraj, Teichmann, Sarah A, Misharin, Alexander V, Nawijn, Martijn C

“…Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing…”
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Impact of Transcriptomics on Our Understanding of Pulmonary Fibrosis by Vukmirovic, Milica, Kaminski, Naftali

“…Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease characterized by aberrant remodeling of the lung parenchyma with extensive changes to the…”
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An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm by Lino Cardenas, Christian L., Kessinger, Chase W., Cheng, Yisha, MacDonald, Carolyn, MacGillivray, Thomas, Ghoshhajra, Brian, Huleihel, Luai, Nuri, Saifar, Yeri, Ashish S., Jaffer, Farouc A., Kaminski, Naftali, Ellinor, Patrick, Weintraub, Neal L., Malhotra, Rajeev, Isselbacher, Eric M., Lindsay, Mark E.

“…Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators of the…”
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A Markov random field model for network-based differential expression analysis of single-cell RNA-seq data by Li, Hongyu, Zhu, Biqing, Xu, Zhichao, Adams, Taylor, Kaminski, Naftali, Zhao, Hongyu

“…Recent development of single cell sequencing technologies has made it possible to identify genes with different expression (DE) levels at the cell type level…”
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Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors by Hurley, Killian, Ding, Jun, Villacorta-Martin, Carlos, Herriges, Michael J., Jacob, Anjali, Vedaie, Marall, Alysandratos, Konstantinos D., Sun, Yuliang L., Lin, Chieh, Werder, Rhiannon B., Huang, Jessie, Wilson, Andrew A., Mithal, Aditya, Mostoslavsky, Gustavo, Oglesby, Irene, Caballero, Ignacio S., Guttentag, Susan H., Ahangari, Farida, Kaminski, Naftali, Rodriguez-Fraticelli, Alejo, Camargo, Fernando, Bar-Joseph, Ziv, Kotton, Darrell N.

“…Alveolar epithelial type 2 cells (AEC2s) are the facultative progenitors responsible for maintaining lung alveoli throughout life but are difficult to isolate…”
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