Search Results - "KAMEN, Barton A"

The anti-angiogenic basis of metronomic chemotherapy by Kerbel, Robert S, Kamen, Barton A

“…In addition to proliferating cancer cells and various types of normal cells, such as those of the bone marrow, conventional cytotoxic chemotherapeutics affect…”
Get full text

Functional folate receptor alpha is elevated in the blood of ovarian cancer patients by Basal, Eati, Eghbali-Fatourechi, Guiti Z, Kalli, Kimberly R, Hartmann, Lynn C, Goodman, Karin M, Goode, Ellen L, Kamen, Barton A, Low, Philip S, Knutson, Keith L

“…Despite low incidence, ovarian cancer is the fifth leading cause of cancer deaths and it has the highest mortality rate of all gynecologic malignancies among…”
Get full text

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development by Piedrahita, Jorge A, Bennett, Gregory D, Finnell, Richard H, van Waes, Janée, Oetama, Betty, Richardson, James, Lacey, Stephen W, Anderson, Richard G.W, Kamen, Barton A

“…Periconceptional folic acid supplementation reduces the occurrence of several human congenital malformations, including craniofacial, heart and neural tube…”
Get full text

Targeting Ras Signaling through Inhibition of Carboxyl Methylation: An Unexpected Property of Methotrexate by Winter-Vann, Ann M., Kamen, Barton A., Bergo, Martin O., Young, Stephen G., Melnyk, Stepan, James, S. Jill, Casey, Patrick J.

“…The antifolate methotrexate is one of the most successful drugs in cancer chemotherapy. Although its efficacy is widely attributed to a decrease in nucleotide…”
Get full text

Folate Homeostasis in Cerebrospinal Fluid During Therapy for Acute Lymphoblastic Leukemia by Cole, Peter D., MD, Beckwith, Katherine A., BA, MPH, Vijayanathan, Veena, PhD, Roychowdhury, Sudipta, MD, Smith, Angela K, Kamen, Barton A., MD, PhD

“…The neurotoxic effects of therapy for childhood acute lymphoblastic leukemia can result in leukoencephalopathy or measurable deficits in cognitive function…”
Get full text

High-Dose Methotrexate in Acute Lymphoblastic Leukemia: Where Is the Evidence for Its Continued Use? by Mantadakis, Elpis, Cole, Peter D., Kamen, Barton A.

“…High‐dose intravenous methotrexate is an important component of many effective chemotherapeutic regimens for childhood acute lymphoblastic leukemia (ALL). Its…”
Get full text

Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells by Cho, Robert C, Cole, Peter D, Sohn, Kyoung-Jin, Gaisano, Gregory, Croxford, Ruth, Kamen, Barton A, Kim, Young-In

“…Folylpolyglutamyl synthase (FPGS) converts intracellular folates and antifolates to polyglutamates. Polyglutamylated folates and antifolates are retained in…”
Get full text

A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro by Kamen, Barton A, Smith, Angel K

“…Folate receptor alpha (FRα), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as…”
Get full text

Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World? by Klement, Giannoula Lakka, Kamen, Barton A

Get full text

Phase II Trial of Oral Aminopterin for Adults and Children with Refractory Acute Leukemia by Cole, Peter D, Drachtman, Richard A, Smith, Angela K, Cate, Sarah, Larson, Richard A, Hawkins, Douglas S, Holcenberg, John, Kelly, Kara, Kamen, Barton A

“…Purpose: To determine the antileukemic activity of weekly oral aminopterin in patients with refractory acute leukemia; to describe the pharmacodynamic…”
Get full text

Setting priorities by Kamen, Barton A

Get full text

What I did on my summer vacation by Kamen, Barton A

Get full text

Looking at the seemingly contradictory role of vinblastine in anaplastic large-cell lymphoma from a metronomic perspective by André, Nicolas, Pasquier, Eddy, Gentet, Jean Claude, Kamen, Barton A

Get full text

Systemic methotrexate exposure is greater after Intrathecal than after oral administration by BOSTROM, Bruce C, ERDMANN, Gary R, KAMEN, Barton A

“…To compare systemic exposure after intrathecal and oral methotrexate administration. We analyzed red cell methotrexate polyglutamate concentrations with a…”
Get full text

Cancer pain, suffering, and spirituality: a Middle Eastern Cancer Consortium meeting by Kamen, Barton A

Get full text

CALLA and protein kinase CK2 revisited: targetable molecules for treating patients with leukemia? by Kamen, Barton A

Get full text

Clinical aspects of pharmacogenetics of pain and co-morbidities of emotional distress by Kamen, Barton A

“…The majority of patients treated for cancer will have pain at some point in their journey. It will be due to the disease (e.g. bone metastasis, fracture, organ…”
Get more information

Serendipity-methotrexate and 6-mercaptopurine for continuation therapy for patients with acute lymphoblastic leukemia: the leukemic stem cell and beyond? by Kamen, Barton A

Get full text

Felix sit Annus Novus; Akemashite Omedetou Gozaimasu; Godt NytAr; Shana Tova; Gelukkig Nieuwjaar; Ein Glückliches Neues Jahr; Sehe Bokmanee Bateuseyo; Eutychismenos o kainourgios Chronos (and more!) by Kamen, Barton A

Get full text

High-dose methotrexate: insecure rationale: take 2 by Kamen, Barton A

Get full text