Search Results - "KAMEI, Kenshi"

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    Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs by Ozaki, Ken-ichi, Yogo, Kenji, Sudo, Hirokazu, Onoma, Mitsu, Kamei, Kenshi, Akima, Michitaka, Koga, Hiroshi, Itoh, Zen, Omura, Satoshi, Takanashi, Hisanori

    Published in Pharmacology (01-01-2007)
    “…The effects of mitemcinal (GM-611) on the gastrointestinal contractile activity were investigated using chronically implanted force transducers in conscious…”
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    ORAL MITEMCINAL (GM-611), AN ERYTHROMYCIN-DERIVED PROKINETIC, ACCELERATES NORMAL AND EXPERIMENTALLY DELAYED GASTRIC EMPTYING IN CONSCIOUS DOGS by Onoma, Mitsu, Yogo, Kenji, Ozaki, Ken-ichi, Kamei, Kenshi, Akima, Michitaka, Koga, Hiroshi, Itoh, Zen, Ōmura, Satoshi, Takanashi, Hisanori

    “…SUMMARY 1 We examined effects of orally administered mitemcinal, an erythromycin‐derived motilin agonist, on gastric emptying and antroduodenal motility in…”
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    Discovery of novel motilin antagonists: Conversion of tetrapeptide leads to orally available peptidomimetics by Taka, Naoki, Matsuoka, Hiroharu, Sato, Tsutomu, Yoshino, Hitoshi, Imaoka, Ikuhiro, Sato, Haruhiko, Kotake, Ken-ichiro, Kumagai, Yoshikazu, Kamei, Kenshi, Ozaki, Ken-ichi, Higashida, Atsuko, Kuroki, Toshio

    Published in Bioorganic & medicinal chemistry letters (01-07-2009)
    “…Peptidomimetic motilin antagonists ( 17c and 17d) were identified. Both compounds dose-dependently suppressed motilin-induced colonic and gastric motility in…”
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    Contractile mechanism of GM-611 on gastrointestinal motility in conscious dogs by Sudo, Hirokazu, Ozaki, Ken-ichi, Onoma, Mitsu, Kamei, Kenshi, Dan, Takashi, Takanashi, Hisanori, Itoh, Zen, Omura, Satoshi

    Published in Japanese Journal of Pharmacology (2000)
    “…GM-611, an acid-resistant erythromycin A derivative, is currently under clinical trials as a gastroprokinetic agent. It has been demonstrated that GM-611…”
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    Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones by Yamaguchi, Masahisa, Kamei, Kenshi, Koga, Takaki, Akima, Michitaka, Kuroki, Toshio, Ohi, Nobuhiro

    Published in Journal of medicinal chemistry (01-12-1993)
    “…A number of 4-substituted 2-[omega-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2…”
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    Effects of KC-515, a new K channel opener, in several hypertensive and hyperlipidemia models of rats by Sugo, Izumi, Yoshida, Shohshin, Satoh, Kimihiko, Kamei, Kenshi, Imagawa, Jun-ichi, Akima, Michitaka, Nabata, Hiroyuki, Hayasaka, Akira, Chiba, Nobuyuki

    Published in Japanese Journal of Pharmacology (1994)
    “…KC-515 is a newly synthesized potent potassium channel opener. We examined antihypertensive effects of KC-515 in several conscious rat models of experimental…”
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    Acceleratory effect of GM-611 on defecation in rabbits by Hirokazu Sudo, Hiroyasu Muramatsu, Tatsuo Yata, Ken-ichi Ozaki, Kenshi Kamei, Zen Itoh, Satoshi Omura

    “…GM-611, a motilin receptor agonist, is currently under clinical trials as a gastroprokinetic agent. It has been demonstrated that GM-611 stimulates the upper…”
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    Hemodynamic and Hormonal Responses to Nicorandil in a Canine Model of Acute Ischemic Heart Failure: A Comparison with Cromakalim and Nitroglycerin by Kamijo, Takeshi, Kamei, Kenshi, Sugo, Izumi, Kamiyama, Toru, Sudo, Hirokazu, Ohba, Yasuhiro

    Published in Journal of cardiovascular pharmacology (01-01-1999)
    “…The pharmacologic profiles of nicorandil in the cardiovascular system have been characterized by K-channel opening and nitrate activities. However, the effects…”
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    Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones by Yamaguchi, Masahisa, Kamei, Kenshi, Koga, Takaki, Akima, Michitaka, Maruyama, Akinori, Kuroki, Toshio, Ohi, Nobuhiro

    Published in Journal of medicinal chemistry (01-12-1993)
    “…A series of novel 4-(3-pyridyl)-1(2H)-phthalazinone derivatives which possess dual activities of thromboxane A2 (TXA2) synthetase inhibition and…”
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    Regional and species differences in glyburide‐sensitive K+ channels in airway smooth muscles as estimated from actions of KC 128 and levcromakalim by Kamei, Kenshi, Yoshida, Shohshin, Imagawa, Jun‐Ichi, Nabata, Hiroyuki, Kuriyama, Hirosi

    Published in British journal of pharmacology (01-11-1994)
    “…1 The purpose of the present experiments was to elucidate the differences in actions of two K+ channel openers, KC 128 and levcromakalim, on the…”
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    Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. V: Thienopyridazinone derivatives by YAMAGUCHI, M, MARUYAMA, N, KOGA, T, KAMEI, K, AKIMA, M, KUROKI, T, HAMANA, M, OHI, N

    “…Synthesis and pharmacological evaluation of novel thienopyridazinones and related compounds are described. A thiophene ring was found to be able to replace the…”
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    Effect of KC399, a newly synthesized K+ channel opener, on acetylcholine‐induced electrical and mechanical activities in rabbit tracheal smooth muscle by Kamei, Kenshi, Nabata, Hiroyuki, Kuriyama, Hirosi, Watanabe, Yoshimasa, Itoh, Takeo

    Published in British journal of pharmacology (01-08-1995)
    “…1 Effects of KC399, an opener of ATP‐sensitive K+ channels were investigated on membrane potential, isometric force and intracellular Ca2+ ([Ca2+]i…”
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    Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. V.Thienopyridazinone Derivatives by YAMAGUCHI, Masahisa, MARUYAMA, Noriaki, KOGA, Takaki, KAMEI, Kenshi, AKIMA, Michitaka, KUROKI, Toshio, HAMANA, Masatomo, OHI, Nobuhiro

    Published in Chemical and Pharmaceutical Bulletin (15-02-1995)
    “…Synthesis and pharmacological evaluation of novel thienopyridazinones and related compounds are described.A thiophene ring was found to be able to replace the…”
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    Novel Antiasthematic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. IV.2-[2-(1-Imidazolyl)ethyl]-4-(3-pyridyl-1(2H)-phthalazinones by YAMAGUCHI, Masahisa, KOGA, Takaki, KAMEI, Kenshi, AKIMA, Michitaka, MARUYAMA, Noriaki, KUROKI, Toshio, HAMANA, Masatomo, OHI, Nobuhiro

    Published in Chemical & pharmaceutical bulletin (15-09-1994)
    “…Synthesis and pharmacological evaluation of several compounds related to 2-[2-(1-imidazolyl)ethyl]-4-(3-pyridyl)-1(2H)-phthalazinones are described. The phenyl…”
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    Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. III. 4-[2-(5-Ethyl-2-thienyl)]-2'-[2-(1-imidazolyl)ethyl]-1(2H)-phthalazinones by YAMAGUCHI, Masahisa, KOGA, Takaki, KAMEI, Kenshi, AKIMA, Michitaka, KUROKI, Toshio, HAMANA, Masatomo, OHI, Nobuhiro

    Published in Chemical & pharmaceutical bulletin (01-08-1994)
    “…Synthesis and pharmacological evaluation of novel 4-[2-(5-ethyl-2-thienyl)]-2-[2-(1-imidazolyl)ethyl]-1(2H)-phthalazinones are described. The phenyl moiety of…”
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    Novel Antiasthmatic Agents with Dual Activities of Thromboxane A2 Synthetase Inhibition and Bronchodilation. VI. Indazole Derivatives by YAMAGUCHI, Masahisa, MARUYAMA, Noriaki, KOGA, Takaki, KAMEI, Kenshi, AKIMA, Michitaka, KUROKI, Toshio, HAMANA, Masatomo, OHI, Nobuhiro

    “…Synthesis and pharmacological evaluation of novel indazole derivatives are described. These compounds were found to exhibit both thromboxane A2 (TXA2)…”
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    Contribution of the tissue angiotensin converting enzyme to the antihypertensive effect of altiopril calcium (MC-838) in spontaneously hypertensive rats by Kamei, K, Shiraki, Y, Koga, T, Sakai, K

    Published in Journal of pharmacy and pharmacology (01-04-1989)
    “…The effect of a new orally active angiotensin converting enzyme (ACE) inhibitor, calcium (-)-N-[(S)-3-[(N-cyclohexylcarbonyl-D-alanyl)thio]-2-methylpropionyl+…”
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