Search Results - "KAMBARA, Hirokazu"
-
1
Mobile endovascular therapy for acute treatment of ruptured vertebral artery dissecting aneurysm in multiple hospitals
Published in Acta neurochirurgica (01-02-2022)“…Background The patients with ruptured vertebral artery dissecting aneurysm (rVADA) should be treated as early as possible because VADA carries extremely high…”
Get full text
Journal Article -
2
An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor
Published in Cancer research (Chicago, Ill.) (01-04-2005)“…Oncolytic herpes simplex virus-1 (HSV-1) mutants possessing mutations in the ICP34.5 and ICP6 genes have proven safe through clinical trials. However,…”
Get full text
Journal Article -
3
Volumetric Tomography of Fluorescent Proteins through Small Animals in vivo
Published in Proceedings of the National Academy of Sciences - PNAS (20-12-2005)“…Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in…”
Get full text
Journal Article -
4
Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas
Published in Neuropathology (01-12-2012)“…Accumulating evidence indicates that VEGF and matrix metalloproteinase‐9 (MMP‐9) play a central role in the development of peritumoral brain edema (PTBE)…”
Get full text
Journal Article -
5
Proteomics-based analysis of invasion-related proteins in malignant gliomas
Published in Neuropathology (01-06-2013)“…One of the insidious biological features of gliomas is their potential to extensively invade normal brain tissue, yet molecular mechanisms that dictate this…”
Get full text
Journal Article -
6
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas
Published in Journal of neuro-oncology (01-12-2004)“…We examined the radiological and histological features of, and the influences of the expression of VEGF and its two major receptors, Flt-1 and Flk-1, on the…”
Get full text
Journal Article -
7
Mixed germ cell tumor and hemangioblastoma in the cerebellum: report of a rare coexistence
Published in Brain tumor pathology (01-07-2011)“…We report a case of a cerebellar tumor consisting of a mixed germ cell tumor (GCT) and a hemangioblastoma. A 22-year-old man presented with myoclonus and…”
Get full text
Journal Article -
8
Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes
Published in Cancer gene therapy (01-10-2002)“…Radiation therapy is an established modality for the treatment of malignant gliomas. Several reports have shown the advantage of additional radiation in…”
Get full text
Journal Article -
9
Novel Animal Glioma Models that Separately Exhibit Two Different Invasive and Angiogenic Phenotypes of Human Glioblastomas
Published in World neurosurgery (01-12-2012)“…Objective Invasive behaviors of malignant gliomas are fundamental traits and major reasons for treatment failure. Delineation of invasive growth is important…”
Get full text
Journal Article -
10
Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus
Published in Cancer research (Chicago, Ill.) (15-12-2005)“…The success of cancer virotherapy depends on its efficacy versus toxicity profile in human clinical trials. Progress towards clinical trials can be hampered by…”
Get full text
Journal Article -
11
Efficacy and Safety of the Oncolytic Herpes Simplex Virus rRp450 Alone and Combined With Cyclophosphamide
Published in Molecular therapy (01-05-2008)“…Oncolytic herpes simplex virus (oHSV) mutants are under development as anticancer therapeutics. One such vector, rRp450, is ICP6-deleted and expresses a…”
Get full text
Journal Article -
12
Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus
Published in Journal of neuro-oncology (2004)“…Previously, we evaluated the therapeutic efficacy of the adenovirus-mediated transduction of the cytosine deaminase (CD) gene and 5-fluorocytosine (5-FC) for…”
Get full text
Journal Article -
13
624. Effect of an Oncolytic HSV Mutant Expressing ICP34.5 under Control of a Nestin Promoter for Brain Tumor Therapy
Published in Molecular therapy (01-05-2004)“…HSV mutants (e.g. G207 and MGH1), possessing deletions in both copies of the ICP34.5 gene and an insertional mutation in the ICP6 gene (ribonucleotide…”
Get full text
Journal Article -
14
657. Combination Therapy with Cyclophosphamide and the Oncolytic Herpes Virus Mutant rRp450, Expressing a Cyclophosphamide Prodrug, Is Clinically Safe by Intratumoral, Intravenous, and Intracerebral Administration in an HSV-1 Susceptible Mouse Model
Published in Molecular therapy (01-05-2006)“…PURPOSE: Attenuated Herpes simplex virus (HSV) mutants are being actively pursued for cancer therapy. rRp450 is derived from the HSV-1 strain KOS, but is…”
Get full text
Journal Article -
15
Prognostic value of loss of heterozygosity around three candidate tumor suppressor genes on chromosome 10q in astrocytomas
Published in Journal of neuro-oncology (01-06-2002)“…We thoroughly examined loss of heterozygosity (LOH) around three candidate tumor suppressor genes on chromosome 10q to determine whether LOH of each tumor…”
Get full text
Journal Article