Search Results - "KAMBARA, Hirokazu"

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  1. 1

    Mobile endovascular therapy for acute treatment of ruptured vertebral artery dissecting aneurysm in multiple hospitals by Kidani, Naoya, Sugiu, Kenji, Terasaka, Kaoru, Nakashima, Hiroyuki, Tokunaga, Koji, Kobayashi, Kazuki, Kambara, Hirokazu, Hishikawa, Tomohito, Hiramatsu, Masafumi, Date, Isao

    Published in Acta neurochirurgica (01-02-2022)
    “…Background The patients with ruptured vertebral artery dissecting aneurysm (rVADA) should be treated as early as possible because VADA carries extremely high…”
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  2. 2

    An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor by KAMBARA, Hirokazu, OKANO, Hideyuki, CHIOCCA, E. Antonio, SAEKI, Yoshinaga

    Published in Cancer research (Chicago, Ill.) (01-04-2005)
    “…Oncolytic herpes simplex virus-1 (HSV-1) mutants possessing mutations in the ICP34.5 and ICP6 genes have proven safe through clinical trials. However,…”
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  3. 3

    Volumetric Tomography of Fluorescent Proteins through Small Animals in vivo by Giannis Zacharakis, Hirokazu Kambara, Helen Shih, Ripoll, Jorge, Grimm, Jan, Saeki, Yoshinaga, Weissleder, Ralph, Ntziachristos, Vasilis, Chance, Britton

    “…Volumetric detection and accurate quantification of fluorescent proteins in entire animals would greatly enhance our ability to monitor biological processes in…”
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  4. 4

    Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas by Iwado, Eiji, Ichikawa, Tomotsugu, Kosaka, Hiroshi, Otsuka, Shinji, Kambara, Hirokazu, Tamiya, Takashi, Kondo, Seiji, Date, Isao

    Published in Neuropathology (01-12-2012)
    “…Accumulating evidence indicates that VEGF and matrix metalloproteinase‐9 (MMP‐9) play a central role in the development of peritumoral brain edema (PTBE)…”
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  5. 5

    Proteomics-based analysis of invasion-related proteins in malignant gliomas by Maruo, Tomoko, Ichikawa, Tomotsugu, Kanzaki, Hirotaka, Inoue, Satoshi, Kurozumi, Kazuhiko, Onishi, Manabu, Yoshida, Koichi, Kambara, Hirokazu, Ouchida, Mamoru, Shimizu, Kenji, Tamaru, Seiji, Chiocca, E. Antonio, Date, Isao

    Published in Neuropathology (01-06-2013)
    “…One of the insidious biological features of gliomas is their potential to extensively invade normal brain tissue, yet molecular mechanisms that dictate this…”
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  6. 6

    The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas by OTSUKA, Shinji, TAMIYA, Takashi, ONO, Yasuhiro, MICHIUE, Hiroyuki, KUROZUMI, Kazuhiko, DAIDO, Shigeru, KAMBARA, Hirokazu, DATE, Isao, OHMOTO, Takashi

    Published in Journal of neuro-oncology (01-12-2004)
    “…We examined the radiological and histological features of, and the influences of the expression of VEGF and its two major receptors, Flt-1 and Flk-1, on the…”
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  7. 7

    Mixed germ cell tumor and hemangioblastoma in the cerebellum: report of a rare coexistence by Ichikawa, Tomotsugu, Hamazaki, Shuji, Sakai, Naoto, Otsuki, Yoshiro, Wataya, Takafumi, Kambara, Hirokazu, Shuin, Taro, Date, Isao

    Published in Brain tumor pathology (01-07-2011)
    “…We report a case of a cerebellar tumor consisting of a mixed germ cell tumor (GCT) and a hemangioblastoma. A 22-year-old man presented with myoclonus and…”
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  8. 8

    Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes by Kambara, Hirokazu, Tamiya, Takashi, Ono, Yasuhiro, Ohtsuka, Shinji, Terada, Kinya, Adachi, Yoshiaki, Ichikawa, Tomotsugu, Hamada, Hirofumi, Ohmoto, Takashi

    Published in Cancer gene therapy (01-10-2002)
    “…Radiation therapy is an established modality for the treatment of malignant gliomas. Several reports have shown the advantage of additional radiation in…”
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  9. 9

    Novel Animal Glioma Models that Separately Exhibit Two Different Invasive and Angiogenic Phenotypes of Human Glioblastomas by Inoue, Satoshi, Ichikawa, Tomotsugu, Kurozumi, Kazuhiko, Maruo, Tomoko, Onishi, Manabu, Yoshida, Koichi, Fujii, Kentaro, Kambara, Hirokazu, Chiocca, E. Antonio, Date, Isao

    Published in World neurosurgery (01-12-2012)
    “…Objective Invasive behaviors of malignant gliomas are fundamental traits and major reasons for treatment failure. Delineation of invasive growth is important…”
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  10. 10

    Cyclophosphamide allows for in vivo dose reduction of a potent oncolytic virus by KAMBARA, Hirokazu, SAEKI, Yoshinaga, CHIOCCA, E. Antonio

    Published in Cancer research (Chicago, Ill.) (15-12-2005)
    “…The success of cancer virotherapy depends on its efficacy versus toxicity profile in human clinical trials. Progress towards clinical trials can be hampered by…”
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  11. 11

    Efficacy and Safety of the Oncolytic Herpes Simplex Virus rRp450 Alone and Combined With Cyclophosphamide by Currier, Mark A, Gillespie, Rebecca A, Sawtell, Nancy M, Mahller, Yonatan Y, Stroup, Greg, Collins, Margaret H, Kambara, Hirokazu, Chiocca, E Antonio, Cripe, Timothy P

    Published in Molecular therapy (01-05-2008)
    “…Oncolytic herpes simplex virus (oHSV) mutants are under development as anticancer therapeutics. One such vector, rRp450, is ICP6-deleted and expresses a…”
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  12. 12

    Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus by KUROZUMI, Kazuhiko, TAMIYA, Takashi, ONO, Yasuhiro, OTSUKA, Shinji, KAMBARA, Hirokazu, ADACHI, Yoshiaki, ICHIKAWA, Tomotsugu, HAMADA, Hirofumi, OHMOTO, Takashi

    Published in Journal of neuro-oncology (2004)
    “…Previously, we evaluated the therapeutic efficacy of the adenovirus-mediated transduction of the cytosine deaminase (CD) gene and 5-fluorocytosine (5-FC) for…”
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  13. 13

    624. Effect of an Oncolytic HSV Mutant Expressing ICP34.5 under Control of a Nestin Promoter for Brain Tumor Therapy by Kambara, Hirokazu, Okano, Hideyuki, Chiocca, E Antonio, Saeki, Yoshinaga

    Published in Molecular therapy (01-05-2004)
    “…HSV mutants (e.g. G207 and MGH1), possessing deletions in both copies of the ICP34.5 gene and an insertional mutation in the ICP6 gene (ribonucleotide…”
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  14. 14
  15. 15

    Prognostic value of loss of heterozygosity around three candidate tumor suppressor genes on chromosome 10q in astrocytomas by TERADA, Kinya, TAMIYA, Takashi, SHIMIZU, Kenji, DAIDO, Shigeru, KAMBARA, Hirokazu, TANAKA, Hiroaki, ONO, Yasuhiro, MATSUMOTO, Kengo, ITO, Sachio, OUCHIDA, Mamoru, OHMOTO, Takashi

    Published in Journal of neuro-oncology (01-06-2002)
    “…We thoroughly examined loss of heterozygosity (LOH) around three candidate tumor suppressor genes on chromosome 10q to determine whether LOH of each tumor…”
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