Search Results - "KAMADA, Haruhiko"

Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation by Takahashi, Yu, Shinoda, Akihiro, Kamada, Haruhiko, Shimizu, Makoto, Inoue, Jun, Sato, Ryuichiro

“…Perilipin2 (Plin2), also known as adipose differentiation-related protein (ADRP), or adipophilin, is a member of the PAT family involved in lipid droplet (LD)…”
Get full text

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab by Kato, Daiki, Yaguchi, Tomonori, Iwata, Takashi, Katoh, Yuki, Morii, Kenji, Tsubota, Kinya, Takise, Yoshiaki, Tamiya, Masaki, Kamada, Haruhiko, Akiba, Hiroki, Tsumoto, Kouhei, Serada, Satoshi, Naka, Tetsuji, Nishimura, Ryohei, Nakagawa, Takayuki, Kawakami, Yutaka

“…Current xenogeneic mouse models cannot evaluate on-target off-tumor adverse effect, hindering the development of chimeric antigen receptor (CAR) T cell…”
Get full text

Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities by Tanaka, Yuya, Tanioku, Yurika, Nakayama, Taisuke, Aso, Kotomi, Yamaguchi, Takao, Kamada, Haruhiko, Obika, Satoshi

“…[Display omitted] Herein, we describe the design and synthesis of multi-conjugatable fatty acid monomer phosphoramidites and their conjugation to antisense…”
Get full text

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing by Akiba, Hiroki, Ise, Tomoko, Nagata, Satoshi, Kamada, Haruhiko, Ohno, Hiroaki, Tsumoto, Kouhei

“…A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of…”
Get full text

COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions by Urano, Emiko, Okamura, Tomotaka, Ono, Chikako, Ueno, Shiori, Nagata, Satoshi, Kamada, Haruhiko, Higuchi, Mahoko, Furukawa, Mugi, Kamitani, Wataru, Matsuura, Yoshiharu, Kawaoka, Yoshihiro, Yasutomi, Yasuhiro

“…The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health and life. A useful pathological animal model…”
Get full text

Development of a detection method for antisense oligonucleotides in mouse kidneys by matrix‐assisted laser desorption/ionization imaging mass spectrometry by Yokoi, Hiroyuki, Kasahara, Yuya, Obika, Satoshi, Doi, Takefumi, Kamada, Haruhiko

“…Rationale Oligonucleotide therapeutics have recently gained much attention, but its pharmacokinetic evaluation methods are still not sufficient, and, in…”
Get full text

ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury by Yamaguchi, Tomokazu, Hoshizaki, Midori, Minato, Takafumi, Nirasawa, Satoru, Asaka, Masamitsu N., Niiyama, Mayumi, Imai, Masaki, Uda, Akihiko, Chan, Jasper Fuk-Woo, Takahashi, Saori, An, Jianbo, Saku, Akari, Nukiwa, Ryota, Utsumi, Daichi, Kiso, Maki, Yasuhara, Atsuhiro, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Fujino, Yuji, Motoyama, Satoru, Nagata, Satoshi, Penninger, Josef M., Kamada, Haruhiko, Yuen, Kwok-Yung, Kamitani, Wataru, Maeda, Ken, Kawaoka, Yoshihiro, Yasutomi, Yasuhiro, Imai, Yumiko, Kuba, Keiji

“…Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a…”
Get full text

Development of a Drug Discovery Method Targeted to Stromal Tissue by Kamada, Haruhiko

“…Several diseases are characterized by alterations in the molecular distribution of vascular structures, presenting the opportunity to use monoclonal antibodies…”
Get full text

Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells by Inoue, Masaki, Tsuji, Yuta, Ueno, Reira, Miyamoto, Daisuke, Tanaka, Keisuke, Moriyasu, Yuka, Shibata, Saya, Okuda, Mei, Ando, Daisuke, Abe, Yasuhiro, Kamada, Haruhiko, Tsunoda, Shin-ichi

“…Recently, TNF receptor type 2 (TNFR2) signaling was found to be involved in the proliferation and activation of regulatory T cells (Tregs), a subpopulation of…”
Get full text

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy by Taki, Shintaro, Kamada, Haruhiko, Inoue, Masaki, Nagano, Kazuya, Mukai, Yohei, Higashisaka, Kazuma, Yoshioka, Yasuo, Tsutsumi, Yasuo, Tsunoda, Shin-ichi

“…Ephrin receptor A10 (EphA10), a transmembrane receptor that binds to ephrin, is a newly identified breast cancer marker protein that has also been detected in…”
Get full text

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes by Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Itoh, Norio, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

“…Clarifying the physicochemical properties of nanomaterials is crucial for hazard assessment and the safe application of these substances. With this in mind, we…”
Get full text

Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice by Hirai, Toshiro, Yoshioka, Yasuo, Izumi, Natsumi, Ichihashi, Ko-ichi, Handa, Takayuki, Nishijima, Nobuo, Uemura, Eiichiro, Sagami, Ko-ichi, Takahashi, Hideki, Yamaguchi, Manami, Nagano, Kazuya, Mukai, Yohei, Kamada, Haruhiko, Tsunoda, Shin-ichi, Ishii, Ken J., Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Many people suffer from metal allergy, and the recently demonstrated presence of naturally occurring metal nanoparticles in our environment could present a new…”
Get full text

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application by Nabeshi, Hiromi, Yoshikawa, Tomoaki, Matsuyama, Keigo, Nakazato, Yasutaro, Matsuo, Kazuhiko, Arimori, Akihiro, Isobe, Masaaki, Tochigi, Saeko, Kondoh, Sayuri, Hirai, Toshiro, Akase, Takanori, Yamashita, Takuya, Yamashita, Kohei, Yoshida, Tokuyuki, Nagano, Kazuya, Abe, Yasuhiro, Yoshioka, Yasuo, Kamada, Haruhiko, Imazawa, Takayoshi, Itoh, Norio, Nakagawa, Shinsaku, Mayumi, Tadanori, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

“…Abstract Currently, nanomaterials (NMs) with particle sizes below 100 nm have been successfully employed in various industrial applications in medicine,…”
Get full text

Protein corona changes mediated by surface modification of amorphous silica nanoparticles suppress acute toxicity and activation of intrinsic coagulation cascade in mice by Yoshida, Tokuyuki, Yoshioka, Yasuo, Morishita, Yuki, Aoyama, Michihiko, Tochigi, Saeko, Hirai, Toshiro, Tanaka, Kota, Nagano, Kazuya, Kamada, Haruhiko, Tsunoda, Shin-ichi, Nabeshi, Hiromi, Yoshikawa, Tomoaki, Higashisaka, Kazuma, Tsutsumi, Yasuo

“…Recently, nanomaterial-mediated biological effects have been shown to be governed by the interaction of nanomaterials with some kinds of proteins in biological…”
Get more information

Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors by NAGANO, KAZUYA, IMAI, SUNAO, ZHAO, XILULI, YAMASHITA, TAKUYA, YOSHIOKA, YASUO, ABE, YASUHIRO, MUKAI, YOHEI, KAMADA, HARUHIKO, NAKAGAWA, SHINSAKU, TSUTSUMI, YASUO, TSUNODA, SHIN-ICHI

“…Metastasis is an important prognosis factor in lung cancer, therefore, it is imperative to identify target molecules and elucidate molecular mechanism of…”
Get full text

Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2-transgenic mice by Asaka, Masamitsu N, Utsumi, Daichi, Kamada, Haruhiko, Nagata, Satoshi, Nakachi, Yutaka, Yamaguchi, Tomokazu, Kawaoka, Yoshihiro, Kuba, Keiji, Yasutomi, Yasuhiro

“…COVID-19, caused by SARS-CoV-2, has spread worldwide with dire consequences. To urgently investigate the pathogenicity of COVID-19 and develop vaccines and…”
Get full text

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers by Nagano, Kazuya, Maeda, Yuka, Kanasaki, So-Ichiro, Watanabe, Takanobu, Yamashita, Takuya, Inoue, Masaki, Higashisaka, Kazuma, Yoshioka, Yasuo, Abe, Yasuhiro, Mukai, Yohei, Kamada, Haruhiko, Tsutsumi, Yasuo, Tsunoda, Shin-ichi

“…Ephrin receptor A10 (EphA10) is a relatively uncharacterized protein which is expressed in many breast cancers but not expressed in normal breast tissues…”
Get full text

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration by Tomita, Kyoko, Sakurai, Fuminori, Iizuka, Shunsuke, Hemmi, Masahisa, Wakabayashi, Keisaku, Machitani, Mitsuhiro, Tachibana, Masashi, Katayama, Kazufumi, Kamada, Haruhiko, Mizuguchi, Hiroyuki

“…Pre-existing anti-adenovirus (Ad) neutralizing antibodies (AdNAbs) are a major barrier in clinical gene therapy using Ad vectors and oncolytic Ads; however, it…”
Get full text

Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus by Kayamuro, Hiroyuki, Yoshioka, Yasuo, Abe, Yasuhiro, Arita, Shuhei, Katayama, Kazufumi, Nomura, Tetsuya, Yoshikawa, Tomoaki, Kubota-Koketsu, Ritsuko, Ikuta, Kazuyoshi, Okamoto, Shigefumi, Mori, Yasuko, Kunisawa, Jun, Kiyono, Hiroshi, Itoh, Norio, Nagano, Kazuya, Kamada, Haruhiko, Tsutsumi, Yasuo, Tsunoda, Shin-ichi

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection by Hirai, Toshiro, Yoshikawa, Tomoaki, Nabeshi, Hiromi, Yoshida, Tokuyuki, Tochigi, Saeko, Ichihashi, Ko-ichi, Uji, Miyuki, Akase, Takanori, Nagano, Kazuya, Abe, Yasuhiro, Kamada, Haruhiko, Itoh, Norio, Tsunoda, Shin-ichi, Yoshioka, Yasuo, Tsutsumi, Yasuo

“…Due to the rising use of nanomaterials (NMs), there is concern that NMs induce undesirable biological effects because of their unique physicochemical…”
Get full text