O-galloyl flavonoids from Geranium pyrenaicum and their in vitro antileishmanial activity

From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-$\beta$-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-$\beta$-D-glucopyranoside (1), quercetin 3-O-$\beta$-D-glucopyranoside (2), que...

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Bibliographic Details
Published in:	Turkish journal of chemistry Vol. 29; no. 4; pp. 437 - 443
Main Authors:	KIDERLER, Albrecht, F, RADTKE, Oliver, A, KALOGA, Maeki, ERCİL, Dilek, SAKAR, M. Koray, KOLODZIEJ, Herbert
Format:	Journal Article
Language:	English
Published:	TÜBİTAK 2005
Online Access:	Get full text
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Summary:	From the aerial parts of Geranium pyrenaicum Burm., a new flavonol glycoside, kaempferol 3-O-(2'',3''-di-O-galloyl)-$\beta$-D-glucopyranoside (7), along with 6 known related glycosides [kaempferol 3-O-$\beta$-D-glucopyranoside (1), quercetin 3-O-$\beta$-D-glucopyranoside (2), quercetin 3-O-$\beta$-D-galactopyranoside (3), kaempferol 3-O-(2''-O-galloyl)-$\beta$-D-glucopyranoside (4), quercetin 3-O-(2''-O-galloyl)-$\beta$-D-glucopyranoside (5) and quercetin 3-O-(2'',3''-di-O-galloyl)-$\beta$-D-glucopyranoside (6)] and the ellagitannins corilagin (8) and tellimagrandin I (9) were isolated. Their structures were established from spectroscopic studies (UV, FAB-MS, $^1H$ and $^{13}C$-NMR, $^1H-^1H$ COSY, HETCOR, HMBC). Compounds 1-7 were evaluated for antileishmanial activity against a panel of Leishmania species (L. major, L. donovani and L. amazonensis), indicating appreciable in vitro activities ($IC_{50}$ 4-27 nM) when compared with Pentostam ($IC_{50}$ 10-11 nM).
Bibliography:	TMUH
ISSN:	1300-0527 1303-6130