Search Results - "KALO, Eyal"

p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways by BUGANIM, Yosef, SOLOMON, Hilla, GORDIN, Maya, RIVLIN, Noa, KOGAN, Ira, BROSH, Ran, SEFADIA-ELAD, Galit, GOLDFINGER, Naomi, SIDRANSKY, David, KLOOG, Yoel, ROTTER, Varda, RAIS, Yoach, KISTNER, Daria, NACHMANY, Ido, BRAIT, Mariana, MADAR, Shalom, GOLDSTEIN, Ido, KALO, Eyal, ADAM, Nitzan

“…In this study, we focus on the analysis of a previously identified cancer-related gene signature (CGS) that underlies the cross talk between the p53 tumor…”
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Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type II by Kalo, Eyal, Buganim, Yosef, Shapira, Keren E., Besserglick, Hilla, Goldfinger, Naomi, Weisz, Lilach, Stambolsky, Perry, Henis, Yoav I., Rotter, Varda

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A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype by Buganim, Yosef, Goldstein, Ido, Lipson, Doron, Milyavsky, Michael, Polak-Charcon, Sylvie, Mardoukh, Corine, Solomon, Hilla, Kalo, Eyal, Madar, Shalom, Brosh, Ran, Perelman, Marina, Navon, Roy, Goldfinger, Naomi, Barshack, Iris, Yakhini, Zohar, Rotter, Varda

“…Partial gain of chromosome arm 17q is an abundant aberrancy in various cancer types such as lung and prostate cancer with a prominent occurrence and prognostic…”
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Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect by Milyavsky, Michael, Shats, Igor, Cholostoy, Alina, Brosh, Ran, Buganim, Yosef, Weisz, Lilach, Kogan, Ira, Cohen, Merav, Shatz, Maria, Madar, Shalom, Kalo, Eyal, Goldfinger, Naomi, Yuan, Jun, Ron, Shulamit, MacKenzie, Karen, Eden, Amir, Rotter, Varda

“…Myocardin is known as an important transcriptional regulator in smooth and cardiac muscle development. Here we found that myocardin is frequently repressed…”
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Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 by Stambolsky, Perry, Tabach, Yuval, Fontemaggi, Giulia, Weisz, Lilach, Maor-Aloni, Revital, Sigfried, Zahava, Shiff, Idit, Kogan, Ira, Shay, Moshe, Kalo, Eyal, Blandino, Giovanni, Simon, Itamar, Oren, Moshe, Rotter, Varda

“…The p53 gene is mutated in many human tumors. Cells of such tumors often contain abundant mutant p53 (mutp53) protein, which may contribute actively to tumor…”
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Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature by Solomon, Hilla, Buganim, Yosef, Kogan-Sakin, Ira, Pomeraniec, Leslie, Assia, Yael, Madar, Shalom, Goldstein, Ido, Brosh, Ran, Kalo, Eyal, Beatus, Tsevi, Goldfinger, Naomi, Rotter, Varda

“…Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular transformation, is well documented. However, the mechanisms by which the various…”
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Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression by Buganim, Yosef, Madar, Shalom, Rais, Yoach, Pomeraniec, Leslie, Harel, Einav, Solomon, Hilla, Kalo, Eyal, Goldstein, Ido, Brosh, Ran, Haimov, Ora, Avivi, Camila, Polak-Charcon, Sylvie, Goldfinger, Naomi, Barshack, Iris, Rotter, Varda

“…Compelling evidences have rendered the tumor microenvironment a crucial determinant in cancer outcome. Activating transcription factor 3 (ATF3), a stress…”
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Various p53 mutant types differently regulate the Ras circuit to induce a cancer-related gene signature by Solomon, Hilla, Buganim, Yosef, Pomeraniec, Leslie, Beatus, Tsevi, Assia, Yael, Kogan-Sakin, Ira, Madar, Shalom, Goldstein, Ido, Brosh, Ran, Kalo, Eyal, Goldfinger, Naomi, Rotter, Varda

“…Concomitant expression of mutant p53 and oncogenic Ras, leading to cellular transformation, is well documented. However, the mechanisms by which the various…”
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Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high ROS levels by Kalo, Eyal, Kogan-Sakin, Ira, Solomon, Hilla, Bar-Nathan, Elad, Shay, Moshe, Shetzer, Yoav, Dekel, Elya, Goldfinger, Naomi, Buganim, Yossi, Stambolsky, Perry, Goldstein, Ido, Madar, Shalom, Rotter, Varda

“…Uncontrolled accumulation of reactive oxygen species (ROS) causes oxidative stress and induces harmful effects. Both high ROS levels and p53 mutations are…”
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Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating transcription factor 3 induction by BUGANIM, Yosef, KALO, Eyal, KALIS, Marina, GOLDFINGER, Naomi, ROTTER, Varda, BROSH, Ran, BESSERGLICK, Hila, NACHMANY, Ido, RAIS, Yoach, STAMBOLSKY, Perry, XIAOHU TANG, MILYAVSKY, Michael, SHATS, Igor

“…Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions,…”
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Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 by Stambolsky, Perry, Tabach, Yuval, Fontemaggi, Giulia, Weisz, Lilach, Maor-Aloni, Revital, Siegfried, Zahava, Shiff, Idit, Kogan, Ira, Shay, Moshe, Kalo, Eyal, Blandino, Giovanni, Simon, Itamar, Oren, Moshe, Rotter, Varda

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Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor {szligbeta}1 (TGF-{szligbeta}1) Signaling Pathway by Repressing the Expression of TGF-{szligbeta} Receptor Type II by Kalo, Eyal, Buganim, Yosef, Shapira, Keren E, Besserglick, Hilla, Goldfinger, Naomi, Weisz, Lilach, Stambolsky, Perry, Henis, Yoav I, Rotter, Varda

“…Both transforming growth factor beta (TGF-{szligbeta}) and p53 have been shown to control normal cell growth. Acquired mutations either in the TGF-{szligbeta}…”
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The Molecular mechanism underlying mutant p53 gain of function in both TGF-β and Nrf2 pathways by Kalo, Eyal

“…More than 50% of human cancer acquires mutation in p53 protein. The acquired mutations may simultaneously lead to both the loss of wild type p53 functions, and…”
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Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species by Kalo, Eyal, Kogan-Sakin, Ira, Solomon, Hilla, Bar-Nathan, Elad, Shay, Moshe, Shetzer, Yoav, Dekel, Elya, Goldfinger, Naomi, Buganim, Yossi, Stambolsky, Perry, Goldstein, Ido, Madar, Shalom, Rotter, Varda

“…Uncontrolled accumulation of reactive oxygen species (ROS) causes oxidative stress and induces harmful effects. Both high ROS levels and p53 mutations are…”
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Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II by Kalo, Eyal, Buganim, Yosef, Shapira, Keren E, Besserglick, Hilla, Goldfinger, Naomi, Weisz, Lilach, Stambolsky, Perry, Henis, Yoav I, Rotter, Varda

“…Both transforming growth factor beta (TGF-beta) and p53 have been shown to control normal cell growth. Acquired mutations either in the TGF-beta signaling…”
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