Search Results - "KALHOR, Neda"

Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint by Hellmann, Matthew D, MD, Chaft, Jamie E, MD, William, William N, MD, Rusch, Valerie, Prof, Pisters, Katherine M W, Prof, Kalhor, Neda, MD, Pataer, Apar, MD, Travis, William D, Prof, Swisher, Stephen G, Prof, Kris, Mark G, Dr Prof

“…Summary Improvements in outcomes for patients with resectable lung cancers have plateaued. Clinical trials of resectable non-small-cell lung cancers with…”
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Validation of Immunohistochemical Assays for Integral Biomarkers in the NCI-MATCH EAY131 Clinical Trial by Khoury, Joseph D, Wang, Wei-Lien, Prieto, Victor G, Medeiros, L Jeffrey, Kalhor, Neda, Hameed, Meera, Broaddus, Russell, Hamilton, Stanley R

“…Biomarkers that guide therapy selection are gaining unprecedented importance as targeted therapy options increase in scope and complexity. In conjunction with…”
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Sequential Tracking of PD-L1 Expression and RAD50 Induction in Circulating Tumor and Stromal Cells of Lung Cancer Patients Undergoing Radiotherapy by Adams, Daniel L, Adams, Diane K, He, Jianzhong, Kalhor, Neda, Zhang, Ming, Xu, Ting, Gao, Hui, Reuben, James M, Qiao, Yawei, Komaki, Ritsuko, Liao, Zhongxing, Edelman, Martin J, Tang, Cha-Mei, Lin, Steven H

“…Evidence suggests that PD-L1 can be induced with radiotherapy and may be an immune escape mechanism in cancer. Monitoring this response is limited, as…”
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Expression of PD-1 and PD-L1 in thymic epithelial neoplasms by Weissferdt, Annikka, Fujimoto, Junya, Kalhor, Neda, Rodriguez, Jaime, Bassett, Roland, Wistuba, Ignacio I, Moran, Cesar A

“…Thymic epithelial neoplasms are rare tumors that are difficult to diagnose and treat. Programmed death 1 (PD-1) receptor and its ligand (PD-L1) are expressed…”
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Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing by Zhang, Jianjun, Fujimoto, Junya, Zhang, Jianhua, Wedge, David C., Song, Xingzhi, Zhang, Jiexin, Seth, Sahil, Chow, Chi-Wan, Cao, Yu, Gumbs, Curtis, Gold, Kathryn A., Kalhor, Neda, Little, Latasha, Mahadeshwar, Harshad, Moran, Cesar, Protopopov, Alexei, Sun, Huandong, Tang, Jiabin, Wu, Xifeng, Ye, Yuanqing, William, William N., Lee, J. Jack, Heymach, John V., Hong, Waun Ki, Swisher, Stephen, Wistuba, Ignacio I., Futreal, P. Andrew

“…Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung…”
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JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer by Shien, Kazuhiko, Papadimitrakopoulou, Vassiliki A, Ruder, Dennis, Behrens, Carmen, Shen, Li, Kalhor, Neda, Song, Juhee, Lee, J Jack, Wang, Jing, Tang, Ximing, Herbst, Roy S, Toyooka, Shinichi, Girard, Luc, Minna, John D, Kurie, Jonathan M, Wistuba, Ignacio I, Izzo, Julie G

“…Molecularly targeted drugs have yielded significant therapeutic advances in oncogene-driven non-small cell lung cancer (NSCLC), but a majority of patients…”
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The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer by Song, Shumei, Honjo, Soichiro, Jin, Jiankang, Chang, Shih-Shin, Scott, Ailing W, Chen, Qiongrong, Kalhor, Neda, Correa, Arlene M, Hofstetter, Wayne L, Albarracin, Constance T, Wu, Tsung-Teh, Johnson, Randy L, Hung, Mien-Chie, Ajani, Jaffer A

“…Esophageal cancer is an aggressive malignancy and often resistant to therapy. Overexpression of EGFR has been associated with poor prognosis of patients with…”
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Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients by Parra, Edwin R, Behrens, Carmen, Rodriguez-Canales, Jaime, Lin, Heather, Mino, Barbara, Blando, Jorge, Zhang, Jianjun, Gibbons, Don L, Heymach, John V, Sepesi, Boris, Swisher, Stephen G, Weissferdt, Annikka, Kalhor, Neda, Izzo, Julie, Kadara, Humam, Moran, Cesar, Lee, Jack J, Wistuba, Ignacio I

“…We investigated the correlation between immunohistochemical PD-L1 expression and tumor-associated immune cells (TAICs) density in non-small cell lung carcinoma…”
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Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations by Riquelme, Erick, Behrens, Carmen, Lin, Heather Y, Simon, George, Papadimitrakopoulou, Vassiliki, Izzo, Julie, Moran, Cesar, Kalhor, Neda, Lee, J Jack, Minna, John D, Wistuba, Ignacio I

“…EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not…”
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Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis by Padanad, Mahesh S., Konstantinidou, Georgia, Venkateswaran, Niranjan, Melegari, Margherita, Rindhe, Smita, Mitsche, Matthew, Yang, Chendong, Batten, Kimberly, Huffman, Kenneth E., Liu, Jingwen, Tang, Ximing, Rodriguez-Canales, Jaime, Kalhor, Neda, Shay, Jerry W., Minna, John D., McDonald, Jeffrey, Wistuba, Ignacio I., DeBerardinis, Ralph J., Scaglioni, Pier Paolo

“…KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular…”
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CD73 expression defines immune, molecular, and clinicopathological subgroups of lung adenocarcinoma by Rocha, Pedro, Salazar, Ruth, Zhang, Jiexin, Ledesma, Debora, Solorzano, Jose L., Mino, Barbara, Villalobos, Pamela, Dejima, Hitoshi, Douse, Dzifa Y., Diao, Lixia, Mitchell, Kyle Gregory, Le, Xiuning, Zhang, Jianjun, Weissferdt, Annikka, Parra-Cuentas, Edwin, Cascone, Tina, Rice, David C., Sepesi, Boris, Kalhor, Neda, Moran, Cesar, Vaporciyan, Ara, Heymach, John, Gibbons, Don L., Lee, J. Jack, Kadara, Humam, Wistuba, Ignacio, Behrens, Carmen, Solis, Luisa Maren

“…Introduction CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in…”
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Typical and Atypical Carcinoid Tumors of the Mediastinum: A Biomarker Analysis of 27 Cases With Clinical Correlation by Zaleski, Michael, Kalhor, Neda, Moran, Cesar A.

“…Thymic typical and atypical carcinoids are rare and appear to be more aggressive than similar tumors in other sites. We retrospectively analyzed a group of…”
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The histologic phenotype of lung cancers is associated with transcriptomic features rather than genomic characteristics by Tang, Ming, Abbas, Hussein A., Negrao, Marcelo V., Ramineni, Maheshwari, Hu, Xin, Hubert, Shawna Marie, Fujimoto, Junya, Reuben, Alexandre, Varghese, Susan, Zhang, Jianhua, Li, Jun, Chow, Chi-Wan, Mao, Xizeng, Song, Xingzhi, Lee, Won-Chul, Wu, Jia, Little, Latasha, Gumbs, Curtis, Behrens, Carmen, Moran, Cesar, Weissferdt, Annikka, Lee, J. Jack, Sepesi, Boris, Swisher, Stephen, Cheng, Chao, Kurie, Jonathan, Gibbons, Don, Heymach, John V., Wistuba, Ignacio I., Futreal, P. Andrew, Kalhor, Neda, Zhang, Jianjun

“…Histology plays an essential role in therapeutic decision-making for lung cancer patients. However, the molecular determinants of lung cancer histology are…”
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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1 by Byers, Lauren Averett, Wang, Jing, Nilsson, Monique B, Fujimoto, Junya, Saintigny, Pierre, Yordy, John, Giri, Uma, Peyton, Michael, Fan, You Hong, Diao, Lixia, Masrorpour, Fatemeh, Shen, Li, Liu, Wenbin, Duchemann, Boris, Tumula, Praveen, Bhardwaj, Vikas, Welsh, James, Weber, Stephanie, Glisson, Bonnie S, Kalhor, Neda, Wistuba, Ignacio I, Girard, Luc, Lippman, Scott M, Mills, Gordon B, Coombes, Kevin R, Weinstein, John N, Minna, John D, Heymach, John V

“…Small cell lung cancer (SCLC) is an aggressive malignancy distinct from non-small cell lung cancer (NSCLC) in its metastatic potential and treatment response…”
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Programmed death ligand 1 testing in non–small cell lung carcinoma cytology cell block and aspirate smear preparations by Noll, Bryce, Wang, Wei‐Lien, Gong, Yun, Zhao, Jun, Kalhor, Neda, Prieto, Victor, Staerkel, Gregg, Roy‐Chowdhuri, Sinchita

“…BACKGROUND Immune checkpoint inhibitors targeting the programmed cell death 1 (PD‐1) receptor and its ligand, programmed death ligand 1 (PD‐L1), have emerged…”
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Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics by Kanagal-Shamanna, Rashmi, Portier, Bryce P, Singh, Rajesh R, Routbort, Mark J, Aldape, Kenneth D, Handal, Brian A, Rahimi, Hamed, Reddy, Neelima G, Barkoh, Bedia A, Mishra, Bal M, Paladugu, Abhaya V, Manekia, Jawad H, Kalhor, Neda, Chowdhuri, Sinchita Roy, Staerkel, Gregg A, Medeiros, L Jeffrey, Luthra, Rajyalakshmi, Patel, Keyur P

“…Increasing use of fine needle aspiration for oncological diagnosis, while minimally invasive, poses a challenge for molecular testing by traditional sequencing…”
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Spindle cell and pleomorphic (“ sarcomatoid” ) carcinomas of the lung: an immunohistochemical analysis of 86 cases by Weissferdt, Annikka, MD, FRCPath, Kalhor, Neda, MD, Canales, Jaime Rodriguez, MD, Fujimoto, Junya, MD, Wistuba, Ignacio I., MD, Moran, Cesar A., MD

“…Spindle cell and pleomorphic carcinomas are currently grouped among sarcomatoid carcinomas of the lung. Due to their unusual occurrence, these tumors have not…”
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Revisiting localized malignant mesothelioma by Mann, Shannon, Khawar, Sidrah, Moran, Cesar, Kalhor, Neda

“…Malignant Mesothelioma is an uncommon tumor that usually presents with diffuse pleural involvement and carries a dismal prognosis. Rarely, however, it can…”
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Pretreatment Neutrophil to Lymphocyte Ratio Is Associated with Poor Survival in Patients with Stage I-III Non-Small Cell Lung Cancer by Wang, Jun, Kalhor, Neda, Hu, Jianhua, Wang, Baocheng, Chu, Huili, Zhang, Bicheng, Guan, Yaping, Wu, Yun

“…Neutrophil-to-lymphocyte ratio (NLR) has been shown to be a prognostic indicator in several types of cancer. We aimed to investigate the association between…”
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ConvPath: A software tool for lung adenocarcinoma digital pathological image analysis aided by a convolutional neural network by Wang, Shidan, Wang, Tao, Yang, Lin, Yang, Donghan M., Fujimoto, Junya, Yi, Faliu, Luo, Xin, Yang, Yikun, Yao, Bo, Lin, ShinYi, Moran, Cesar, Kalhor, Neda, Weissferdt, Annikka, Minna, John, Xie, Yang, Wistuba, Ignacio I., Mao, Yousheng, Xiao, Guanghua

“…The spatial distributions of different types of cells could reveal a cancer cell's growth pattern, its relationships with the tumor microenvironment and the…”
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