Search Results - "KALHAN, Satish C"

One carbon metabolism in pregnancy: Impact on maternal, fetal and neonatal health by Kalhan, Satish C.

“…One carbon metabolism or methyl transfer, a crucial component of metabolism in all cells and tissues, supports the critical function of synthesis of purines,…”
Get full text

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid by Kalhan, Satish C., Hanson, Richard W.

“…Serine is generally classified as a nutritionally nonessential (dispensable) amino acid, but metabolically, serine is indispensible and plays an essential role…”
Get full text

What Is the Metabolic Role of Phosphoenolpyruvate Carboxykinase? by Yang, Jianqi, Kalhan, Satish C., Hanson, Richard W.

Get full text

Plasma metabolomic profile in nonalcoholic fatty liver disease by Kalhan, Satish C, Guo, Lining, Edmison, John, Dasarathy, Srinivasan, McCullough, Arthur J, Hanson, Richard W, Milburn, Mike

“…Abstract The plasma profile of subjects with nonalcoholic fatty liver disease (NAFLD), steatosis, and steatohepatitis (NASH) was examined using an untargeted…”
Get full text

Knowledge Gaps and Research Needs for Understanding and Treating Neonatal Hypoglycemia: Workshop Report from Eunice Kennedy Shriver National Institute of Child Health and Human Development by Hay, William W., MD, Raju, Tonse NK., MD, DCH, Higgins, Rosemary D., MD, Kalhan, Satish C., MBBS, FRCP, Devaskar, Sherin U., MD

Get full text

Increased mitochondrial arginine metabolism supports bioenergetics in asthma by Xu, Weiling, Ghosh, Sudakshina, Comhair, Suzy A A, Asosingh, Kewal, Janocha, Allison J, Mavrakis, Deloris A, Bennett, Carole D, Gruca, Lourdes L, Graham, Brian B, Queisser, Kimberly A, Kao, Christina C, Wedes, Samuel H, Petrich, John M, Tuder, Rubin M, Kalhan, Satish C, Erzurum, Serpil C

“…High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium;…”
Get full text

Glyceroneogenesis Is the Dominant Pathway for Triglyceride Glycerol Synthesis in Vivo in the Rat by Nye, Colleen K., Hanson, Richard W., Kalhan, Satish C.

“…Triglyceride synthesis in mammalian tissues requires glycerol 3-phosphate as the source of triglyceride glycerol. In this study the relative contribution of…”
Get full text

The key role of anaplerosis and cataplerosis for citric acid cycle function by Owen, Oliver E, Kalhan, Satish C, Hanson, Richard W

Get full text

Arginine metabolic endotypes related to asthma severity by Xu, Weiling, Comhair, Suzy A A, Janocha, Allison J, Lara, Abigail, Mavrakis, Lori A, Bennett, Carole D, Kalhan, Satish C, Erzurum, Serpil C

“…Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals. We hypothesized that…”
Get full text

Analysis of the adult human plasma metabolome by Lawton, Kay A, Berger, Alvin, Mitchell, Matthew, Milgram, K Eric, Evans, Anne M, Guo, Lining, Hanson, Richard W, Kalhan, Satish C, Ryals, John A, Milburn, Michael V

“…It is well established that disease states are associated with biochemical changes (e.g., diabetes/glucose, cardiovascular disease/cholesterol), as are…”
Get more information

Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis by Dasarathy, Srinivasan, Yang, Yu, McCullough, Arthur J, Marczewski, Susan, Bennett, Carole, Kalhan, Satish C

“…BACKGROUNDData from studies in patients with nonalcoholic steatohepatitis (NASH) suggest an increased hepatic fatty acid oxidation. We have previously shown…”
Get full text

Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine by Kalhan, Satish C, Edmison, John, Marczewski, Susan, Dasarathy, Srinivasan, Gruca, Lourdes L, Bennett, Carole, Duenas, Clarita, Lopez, Rocio

“…Hepatic metabolism of methionine is the source of cysteine, the precursor of glutathione, the major intracellular antioxidant in the body. Methionine also is…”
Get more information

Overexpression of the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) in Skeletal Muscle Repatterns Energy Metabolism in the Mouse by Hakimi, Parvin, Yang, Jianqi, Casadesus, Gemma, Massillon, Duna, Tolentino-Silva, Fatima, Nye, Colleen K., Cabrera, Marco E., Hagen, David R., Utter, Christopher B., Baghdy, Yacoub, Johnson, David H., Wilson, David L., Kirwan, John P., Kalhan, Satish C., Hanson, Richard W.

“…Transgenic mice, containing a chimeric gene in which the cDNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK-C) (EC 4.1.1.32) was linked to the α-skeletal…”
Get full text

Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance by Kelley, David E, McKolanis, Therese M, Hegazi, Refaat A F, Kuller, Lewis H, Kalhan, Satish C

“…The current study was undertaken to examine metabolic and body composition correlates of fatty liver in type 2 diabetes mellitus (DM). Eighty-three men and…”
Get more information

Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women by Bhat, Dattatray S, Gruca, Lourdes L, Bennett, Carole D, Katre, Prachi, Kurpad, Anura V, Yajnik, Chittaranjan S, Kalhan, Satish C

“…Methionine loading test (MLT) has been used primarily to identify defects in transsulfuration of homocysteine in cystathionine beta synthase deficiency. It may…”
Get full text

Metabolic and Genomic Response to Dietary Isocaloric Protein Restriction in the Rat by Kalhan, Satish C., Uppal, Sonal O., Moorman, Jillian L., Bennett, Carole, Gruca, Lourdes L., Parimi, Prabhu S., Dasarathy, Srinivasan, Serre, David, Hanson, Richard W.

“…We have examined hepatic, genomic, and metabolic responses to dietary protein restriction in the non-pregnant Sprague-Dawley rat. Animals were pair-fed either…”
Get full text

TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy by KIRWAN, John P, HAUGUEL-DE MOUZON, Sylvie, LEPERCQ, Jacques, CHALLIER, Jean-Claude, HUSTON-PRESLEY, Larraine, FRIEDMAN, Jacob E, KALHAN, Satish C, CATALANO, Patrick M

“…TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy John P. Kirwan 1 2 , Sylvie Hauguel-De Mouzon 3 , Jacques Lepercq 3 , Jean-Claude Challier 4 ,…”
Get full text

Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension by Heresi, Gustavo A., Mey, Jacob T., Bartholomew, John R., Haddadin, Ihab S., Tonelli, Adriano R., Dweik, Raed A., Kirwan, John P., Kalhan, Satish C.

“…We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach. We…”
Get full text

Nonglucose carbohydrates and infant nutrition and metabolism by Kalhan, Satish C

Get more information

Controversies Regarding Definition of Neonatal Hypoglycemia: Suggested Operational Thresholds by Cornblath, Marvin, Hawdon, Jane M, Williams, Anthony F, Aynsley-Green, Albert, Ward-Platt, Martin P, Schwartz, Robert, Kalhan, Satish C

“…The definition of clinically significant hypoglycemia remains one of the most confused and contentious issues in contemporary neonatology. In this article,…”
Get full text