Search Results - "KAKEHASHI, Anna"

o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice by Yokota, Yuka, Suzuki, Shugo, Gi, Min, Yanagiba, Yukie, Yoneda, Nao, Fujioka, Masaki, Kakehashi, Anna, Koda, Shigeki, Suemizu, Hiroshi, Wanibuchi, Hideki

“…Occupational exposure to aromatic amines is one of the most important risk factors for urinary bladder cancer. When considering the carcinogenesis of aromatic…”
Get full text

Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis by Kakehashi, Anna, Suzuki, Shugo, Ishii, Naomi, Okuno, Takahiro, Kuwae, Yuko, Fujioka, Masaki, Gi, Min, Stefanov, Vasily, Wanibuchi, Hideki

“…To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis,…”
Get full text

FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment by Tagami, Mizuki, Kakehashi, Anna, Katsuyama-Yoshikawa, Atsuko, Misawa, Norihiko, Sakai, Atsushi, Wanibuchi, Hideki, Azumi, Atsushi, Honda, Shigeru

“…Conjunctival squamous cell carcinoma (SCC) is the most common ocular surface neoplasia. The purpose of this retrospective study was to examine the role of…”
Get full text

CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus‐positive patients with resected hepatocellular carcinoma by Kakehashi, Anna, Ishii, Naomi, Sugihara, Eiji, Gi, Min, Saya, Hideyuki, Wanibuchi, Hideki

“…This study investigated whether the expression of CD44 variant 9 (CD44v9) might be a functional marker of tumor‐initiating stem‐like cells in primary…”
Get full text

Expression, intracellular localization, and mutation of EGFR in conjunctival squamous cell carcinoma and the association with prognosis and treatment by Sakai, Atsushi, Tagami, Mizuki, Kakehashi, Anna, Katsuyama-Yoshikawa, Atsuko, Misawa, Norihiko, Wanibuchi, Hideki, Azumi, Atsushi, Honda, Shigeru, Bhattacharya, Sanjoy

“…Purpose Conjunctival squamous cell carcinoma (SCC) is primarily treated with surgical resection. SCC has various stages, and local recurrence is common. The…”
Get full text

In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats by Gi, Min, Fujioka, Masaki, Kakehashi, Anna, Okuno, Takahiro, Masumura, Kenichi, Nohmi, Takehiko, Matsumoto, Michiharu, Omori, Masako, Wanibuchi, Hideki, Fukushima, Shoji

“…1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver…”
Get full text

Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration by Sheema, Asraful Nahar, Naiki-Ito, Aya, Kakehashi, Anna, Ahmed, Omnia Hosny Mohamed, Alexander, David B., Alexander, William T., Numano, Takamasa, Kato, Hiroyuki, Goto, Yuko, Takase, Hiroshi, Hirose, Akihiko, Wakahara, Takatsugu, Miyazawa, Kun’ichi, Takahashi, Satoru, Tsuda, Hiroyuki

“…Fullerene whiskers (FLW)s are thin rod-like structures composed of C 60 and C 70 fullerene (FL). The shape of FLWs suggests potential toxic effects including…”
Get full text

The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β‐catenin signaling by Matsue, Taisuke, Gi, Min, Shiota, Masayuki, Tachibana, Hirokazu, Suzuki, Shugo, Fujioka, Masaki, Kakehashi, Anna, Yamamoto, Tomoki, Kato, Minoru, Uchida, Junji, Wanibuchi, Hideki

“…Carbonic anhydrases (CAs) play an important role in maintaining pH homeostasis. We previously demonstrated that overexpression of CA2 was associated with…”
Get full text

Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats by Kakehashi, Anna, Ishii, Naomi, Fujioka, Masaki, Doi, Kenichiro, Gi, Min, Wanibuchi, Hideki

“…The present study was conducted over a course of 104 weeks to estimate the carcinogenicity of ethanol-extracted Brazilian green propolis (EEP). Groups of 50…”
Get full text

Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens by Fukushima, Shoji, Gi, Min, Kakehashi, Anna, Wanibuchi, Hideki, Matsumoto, Michiharu

“…Qualitative and quantitative approaches are important issues in field of carcinogenic risk assessment of the genotoxic carcinogens. Herein, we provide…”
Get full text

Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model by Fujioka, Masaki, Suzuki, Shugo, Gi, Min, Kakehashi, Anna, Oishi, Yuji, Okuno, Takahiro, Yukimatsu, Nao, Wanibuchi, Hideki

“…Pregnant CD-1 mice received 200 ppm dimethylarsinic acid (DMA) in the drinking water from gestation day 8–18, and tumor formation was assessed in offspring at…”
Get full text

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis by Kakehashi, Anna, Ishii, Naomi, Okuno, Takahiro, Fujioka, Masaki, Gi, Min, Wanibuchi, Hideki

“…The role of deficiency of oxoguanine glycosylase 1 ( ) homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was investigated…”
Get full text

Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis by Suzuki, Shugo, Gi, Min, Komiya, Masami, Obikane, Asuka, Vachiraarunwong, Arpamas, Fujioka, Masaki, Kakehashi, Anna, Totsuka, Yukari, Wanibuchi, Hideki

“…Occupational exposure to aromatic amines (AAs) is an important risk factor for urinary bladder cancer. This study aimed to evaluate the toxicity of AAs and…”
Get full text

Oxidative stress in the carcinogenicity of chemical carcinogens by Kakehashi, Anna, Wei, Min, Fukushima, Shoji, Wanibuchi, Hideki

“…This review highlights several in vivo studies utilizing non-genotoxic and genotoxic chemical carcinogens, and the mechanisms of their high and low dose…”
Get full text

Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma by Tagami, Mizuki, Kasashima, Hiroaki, Kakehashi, Anna, Yoshikawa, Atsuko, Nishio, Mizuho, Misawa, Norihiko, Sakai, Atsushi, Wanibuchi, Hideki, Yashiro, Masakazu, Azumi, Atsushi, Honda, Shigeru

“…To examine the molecular biological differences between conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma and orbital MALT lymphoma in ocular…”
Get full text

Comparative proteomics analysis of gastric cancer stem cells by Morisaki, Tamami, Yashiro, Masakazu, Kakehashi, Anna, Inagaki, Azusa, Kinoshita, Haruhito, Fukuoka, Tatsunari, Kasashima, Hiroaki, Masuda, Go, Sakurai, Katsunobu, Kubo, Naoshi, Muguruma, Kazuya, Ohira, Masaichi, Wanibuchi, Hideki, Hirakawa, Kosei

“…Cancer stem cells (CSCs) are responsible for cancer progression, metastasis, and recurrence. To date, the specific markers of CSCs remain undiscovered. The aim…”
Get full text

Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling by Kakehashi, Anna, Kato, Ayumi, Ishii, Naomi, Wei, Min, Morimura, Keiichirou, Fukushima, Shoji, Wanibuchi, Hideki

“…Valerian is widely used as a traditional medicine to improve the quality of sleep due to interaction of several active components with the γ-aminobutyric acid…”
Get full text

Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis by Kakehashi, Anna, Suzuki, Shugo, Shiota, Masayuki, Raymo, Nina, Gi, Min, Tachibana, Taro, Stefanov, Vasily, Wanibuchi, Hideki

“…In the present study, the role of a novel protein involved in neurite development and endoplasmic reticulum (ER) stress, canopy homolog 2 (CNPY2), was…”
Get full text

Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas by Kakehashi, Anna, Stefanov, Vasily E, Ishii, Naomi, Okuno, Takahiro, Fujii, Hideki, Kawai, Kazuaki, Kawada, Norifumi, Wanibuchi, Hideki

“…To uncover mechanisms of nonalcoholic steatohepatitis (NASH) associated hepatocarcinogenesis, we compared the proteomes of human NASH-associated liver…”
Get full text

Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats by Gi, Min, Fujioka, Masaki, Totsuka, Yukari, Matsumoto, Michiharu, Masumura, Kenichi, Kakehashi, Anna, Yamaguchi, Takashi, Fukushima, Shoji, Wanibuchi, Hideki

“…Quantitative analysis of the mutagenicity and carcinogenicity of the low doses of genotoxic carcinogens present in food is of pressing concern. The purpose of…”
Get full text