Tiagabine is associated with sustained attention during sleep restriction : Evidence for the value of slow-wave sleep enhancement?

To evaluate the impact of enhanced slow-wave sleep (SWS) on behavioral, psychological, and physiologic changes resulting from sleep restriction A double-blind, parallel-group, placebo-controlled design was used to compare tiagabine, 8 mg, (a SWS-enhancing drug) to placebo during 4 nights of sleep re...

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Bibliographic Details
Published in:	Sleep (New York, N.Y.) Vol. 29; no. 4; pp. 433 - 443
Main Authors:	WALSH, James K, RANDAZZO, Angela C, STONE, Kara, EISENSTEIN, Rhody, FEREN, Stephen D, KAJY, Susan, DICKEY, Pam, ROEHRS, Timothy, ROTH, Thomas, SCHWEITZER, Paula K
Format:	Journal Article
Language:	English
Published:	Rochester, MN American Academy of Sleep Medicine 01-04-2006
Subjects:	Activity levels. Psychomotricity Adult Arousal - drug effects Attention - drug effects Biological and medical sciences Double-Blind Method Electroencephalography Female Fundamental and applied biological sciences. Psychology GABA Agonists - administration & dosage GABA Agonists - pharmacology Humans Male Neuropsychological Tests Nipecotic Acids - administration & dosage Nipecotic Acids - pharmacology Polysomnography Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Reaction Time - drug effects Sleep - drug effects Sleep Deprivation - drug therapy Sleep Deprivation - physiopathology Sleep Deprivation - psychology Vigilance. Attention. Sleep Human Reuptake inhibitor Polysomnography Slow wave sleep Tiagabine Electrodiagnosis Placebo GABA Neurotransmitter Double blind study Value Sustained attention Sleep wake cycle
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Summary:	To evaluate the impact of enhanced slow-wave sleep (SWS) on behavioral, psychological, and physiologic changes resulting from sleep restriction A double-blind, parallel-group, placebo-controlled design was used to compare tiagabine, 8 mg, (a SWS-enhancing drug) to placebo during 4 nights of sleep restriction (time in bed = 5 hours per night). Behavioral, psychological, and physiologic measures of the impact of sleep restriction were compared between groups at baseline, during sleep restriction, and following recovery sleep. Two sleep research laboratories. Thirty-eight healthy adults; 9 men and 10 women (mean age: 26.0 +/- 6.1 years) in the placebo group and 8 men and 11 women (mean age: 26.7 +/- 8.1 years) in the tiagabine 8 mg group Both experimental groups underwent 4 nights of sleep restriction. Each group received either tiagabine 8 mg or placebo on all sleep-restriction nights, and both groups received placebo on baseline and recovery nights. Polysomnography documented a SWS-enhancing effect of tiagabine. The placebo group displayed the predicted deficits due to sleep restriction on the Psychomotor Vigilance Task and the Multiple Sleep Latency Test. Compared with placebo, the tiagabine group did not demonstrate impairment in sustained attention on the Psychomotor Vigilance Test, performed better on the Wisconsin Card Sorting Task, reported more restorative sleep, and had less of an increase in afternoon-evening salivary free cortisol. Multiple Sleep Latency Test, ratings of sleepiness, recovery sleep, and other measures did not differ between groups. To our knowledge these findings are the first to be consistent with the hypothesis that pharmacologic SWS enhancement reduces selective aspects of the behavioral, psychological, and physiologic impact of sleep restriction.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0161-8105 1550-9109