Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea

Hypermucoviscous (HV) isolates of Klebsiella pneumoniae have been linked to virulence potential in experimental infections. We examined 33 isolates of K. pneumoniae from patients with bacteraemia for the HV phenotype on agar culture, and determined their virulence potential by screening for capsular...

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Published in:	Epidemiology and infection Vol. 141; no. 2; pp. 334 - 340
Main Authors:	JUNG, S. W., CHAE, H. J., PARK, Y. J., YU, J. K., KIM, S. Y., LEE, H. K., LEE, J. H., KAHNG, J. M., LEE, S. O., LEE, M. K., LIM, J. H., LEE, C. H., CHANG, S. J., AHN, J. Y., LEE, J. W., PARK, Y. G.
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 01-02-2013
Subjects:	Abscesses Anti-Infective Agents - pharmacology Antimicrobial agents Bacteremia - genetics Bacteremia - microbiology Bacterial diseases Bacterial sepsis Bacteriology Biological and medical sciences Cross Infection - etiology Diseases Drug Resistance, Microbial - genetics Electrophoresis, Gel, Pulsed-Field Fundamental and applied biological sciences. Psychology Genes Genotype & phenotype Human bacterial diseases Humans Infections Infectious diseases Klebsiella Klebsiella Infections - genetics Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - genetics Klebsiella pneumoniae - pathogenicity Liver abscess Liver Abscess - etiology Medical sciences Microbiology Miscellaneous Multilocus Sequence Typing - methods Original Papers Phenotype Phenotypes Polymerase Chain Reaction Republic of Korea Retrospective Studies Serotyping - methods String TB, other bacteria Tertiary Care Centers Virulence Virulence Factors - genetics Asia Far east Korea Republic of Korea United States > US Hypermucoviscosity Klebsiella pneumoniae Infection Phenotype Bacteriosis Bacteria Epidemiology Bacteremia Enterobacteriaceae
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Summary:	Hypermucoviscous (HV) isolates of Klebsiella pneumoniae have been linked to virulence potential in experimental infections. We examined 33 isolates of K. pneumoniae from patients with bacteraemia for the HV phenotype on agar culture, and determined their virulence potential by screening for capsular (K) serotype by polymerase chain reaction and the presence of seven virulence factor genes. Fourteen (42·4%) isolates expressed the HV phenotype and 11 of these were serotype K1 or K2; these serotypes were not identified in HV-negative isolates. The genes rmpA, rmpA2, aerobactin, wabG and allS were significantly more frequent in HV than non-HV isolates. Multilocus sequence typing identified 21 sequence types (ST), eight of which were found in HV-positive isolates and the clonal relatedness of isolates of the most frequent types (ST23 and ST11) from different hospitals was confirmed by pulsed-field gel electrophoresis. The HV phenotype was more associated with community-acquired infection with a lower frequency of fatal underlying illness, but with significantly more focal infections, notably liver abscesses. Clinicians should be aware of such clinical impacts of the HV phenotype.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0950-2688 1469-4409
DOI:	10.1017/S0950268812000933