Search Results - "KAHN, Richard"

ARF family GTPases with links to cilia by Fisher, Skylar, Kuna, Damian, Caspary, Tamara, Kahn, Richard A, Sztul, Elizabeth

“…The ADP-ribosylation factor (ARF) superfamily of regulatory GTPases, including both the ARF and ARF-like (ARL) proteins, control a multitude of cellular…”
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The Reality of Type 2 Diabetes Prevention by KAHN, Richard, DAVIDSON, Mayer B

“…Efforts to reduce the burden of type 2 diabetes include attempts to prevent or delay the onset of the disease. Landmark clinical trials have shown that…”
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Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation by Wright, John, Kahn, Richard A, Sztul, Elizabeth

“…Eukaryotic cells require selective sorting and transport of cargo between intracellular compartments. This is accomplished at least in part by vesicles that…”
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ARL13B regulates Sonic hedgehog signaling from outside primary cilia by Gigante, Eduardo D, Taylor, Megan R, Ivanova, Anna A, Kahn, Richard A, Caspary, Tamara

“…ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To…”
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Heed a decade of calls for antibody validation by Kahn, Richard A., Virk, Harvinder S., McPherson, Peter S.

“…Letter to the Editor…”
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ARF GTPases and their GEFs and GAPs: concepts and challenges by Sztul, Elizabeth, Chen, Pei-Wen, Casanova, James E, Cherfils, Jacqueline, Dacks, Joel B, Lambright, David G, Lee, Fang-Jen S, Randazzo, Paul A, Santy, Lorraine C, Schürmann, Annette, Wilhelmi, Ilka, Yohe, Marielle E, Kahn, Richard A

“…Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are required to develop models of its actions in cells. Studying a…”
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Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins by Larkins, Christine E, Aviles, Gladys D Gonzalez, East, Michael P, Kahn, Richard A, Caspary, Tamara

“…Arl13b, a ciliary protein within the ADP-ribosylation factor family and Ras superfamily of GTPases, is required for ciliary structure but has poorly defined…”
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Adductor Canal Block versus Femoral Nerve Block for Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial by Kim, David H, Lin, Yi, Goytizolo, Enrique A, Kahn, Richard L, Maalouf, Daniel B, Manohar, Asha, Patt, Minda L, Goon, Amanda K, Lee, Yuo-yu, Ma, Yan, YaDeau, Jacques T

“…BACKGROUND:This prospective double-blinded, randomized controlled trial compared adductor canal block (ACB) with femoral nerve block (FNB) in patients…”
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Arl13b and the exocyst interact synergistically in ciliogenesis by Seixas, Cecília, Choi, Soo Young, Polgar, Noemi, Umberger, Nicole L, East, Michael P, Zuo, Xiaofeng, Moreiras, Hugo, Ghossoub, Rania, Benmerah, Alexandre, Kahn, Richard A, Fogelgren, Ben, Caspary, Tamara, Lipschutz, Joshua H, Barral, Duarte C

“…Arl13b belongs to the ADP-ribosylation factor family within the Ras superfamily of regulatory GTPases. Mutations in Arl13b cause Joubert syndrome, which is…”
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Toward a model for Arf GTPases as regulators of traffic at the Golgi by Kahn, Richard A.

“…In this review, I summarize the likely roles played by ADP-ribosylation factor (Arf) proteins in the regulation of membrane traffic at the Golgi, from the…”
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The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors by Newman, Laura E, Schiavon, Cara R, Zhou, Chengjing, Kahn, Richard A

“…Mitochondria are essential, dynamic organelles that respond to a number of stressors with changes in morphology that are linked to several mitochondrial…”
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The Impact of Prevention on Reducing the Burden of Cardiovascular Disease by KAHN, Richard, ROBERTSON, Rose Marie, SMITH, Robert, EDDY, David

“…Cardiovascular disease (CVD) is prevalent and expensive. While many interventions are recommended to prevent CVD, the potential effects of a comprehensive set…”
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Roles for ELMOD2 and Rootletin in ciliogenesis by Turn, Rachel E, Linnert, Joshua, Gigante, Eduardo D, Wolfrum, Uwe, Caspary, Tamara, Kahn, Richard A

“…ELMOD2 is a GTPase-activating protein with uniquely broad specificity for ARF family GTPases. We previously showed that it acts with ARL2 in mitochondrial…”
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The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis by Turn, Rachel E., East, Michael P., Prekeris, Rytis, Kahn, Richard A.

“…The ELMOD2 gene has been linked to a number of human pathologies and encodes an ∼32 kDa protein that acts from multiple sites in mammalian cells. Knocking out…”
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Ancient complement and lineage-specific evolution of the Sec7 ARF GEF proteins in eukaryotes by Pipaliya, Shweta V, Schlacht, Alexander, Klinger, Christen M, Kahn, Richard A, Dacks, Joel

“…Guanine nucleotide exchange factors (GEFs) are the initiators of signaling by every regulatory GTPase, which in turn act to regulate a wide array of essential…”
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Interaction of Fapp1 with Arf1 and PI4P at a Membrane Surface: An Example of Coincidence Detection by Liu, Yizhou, Kahn, Richard A., Prestegard, James H.

“…Interactions among ADP-ribosylation factors (ARFs), various adaptor proteins, and membrane lipids are essential for intracellular vesicle transport of a…”
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Dynamic structure of membrane-anchored ArfGTP by Liu, Yizhou, Kahn, Richard A, Prestegard, James H

“…ADP ribosylation factors (Arfs) are N-myristoylated GTP/GDP switch proteins that have key regulatory roles in vesicle transport in eukaryotic cells. ARFs…”
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Age at initiation and frequency of screening to detect type 2 diabetes: a cost-effectiveness analysis by Kahn, Richard, Dr, Alperin, Peter, MD, Eddy, David, MD, Borch-Johnsen, Knut, MD, Buse, John, MD, Feigelman, Justin, Gregg, Edward, PhD, Holman, Rury R, MD, Kirkman, M Sue, MD, Stern, Michael, MD, Tuomilehto, Jaakko, MD, Wareham, Nick J, Prof

“…Summary Background No clinical trials have assessed the effects or cost-effectiveness of sequential screening strategies to detect new cases of type 2…”
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Arl13b regulates Shh signaling from both inside and outside the cilium by Mariani, Laura E, Bijlsma, Maarten F, Ivanova, Anna A, Suciu, Sarah K, Kahn, Richard A, Caspary, Tamara

“…The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) signaling. Missense mutations in ARL13B can cause the…”
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A Trimer Consisting of the Tubulin-specific Chaperone D (TBCD), Regulatory GTPase ARL2, and β-Tubulin Is Required for Maintaining the Microtubule Network by Francis, Joshua W., Newman, Laura E., Cunningham, Leslie A., Kahn, Richard A.

“…Microtubule dynamics involves the polymerization and depolymerization of tubulin dimers and is an essential and highly regulated process required for cell…”
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